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Avissar

Michele Avissar, Johnston, RI US

Patent application numberDescriptionPublished
20120108655Methods of Diagnosing and Treating Carcinomas - Methods of diagnosing a carcinoma include comparing the expression of miRNAs in a sample with a control and determining ratios of expression of miRNAs. Methods of treatment include administering a nucleic acid encoding a miR-375 gene product. Methods of optimizing treatment in a subject include determining expression of an miR21-gene product.05-03-2012

Patricia L. Avissar, New Brunswick, NJ US

Patent application numberDescriptionPublished
20100203639COMPOSITIONS AND METHODS FOR PLANT GENETIC MODIFICATION - Mixed duplex oligonucleotides (MDON) are used to effect site-specific genetic alterations in a target DNA sequence of a plant. The MDON are introduced by electroporation into microspores. Thereafter, plants having a desired genetic alteration are produced by germinating the microspores.08-12-2010

Patricia L. Avissar, East Brunswick, NJ US

Patent application numberDescriptionPublished
20080256668Non-Transgenic Herbicide Resistant Plants - The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphoniorethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phophonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. The present invention also relates to a non-transgenic plant cell in which the EPSPS gene has been mutated, a non-transgenic plant regenerated therefrom, as well as a plant resulting from a cross using a regenerated non-transgenic plant having a mutated EPSPS gene.10-16-2008

Uri Avissar, Kfar-Sava IL

Patent application numberDescriptionPublished
20090306959PERSONAL TEXT ASSISTANT - A method and system of generating personalized annotated text of a core-text, the method and system directed for acquiring a personal data comprising data indicative of the reader's proficiency level for understanding text; and providing at least a gloss to accompany the requested text based on core-text and the reader's proficiency level.12-10-2009