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Avens
Heather Avens, Lafayette, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090137405 | DETECTION OF NUCLEIC ACID BIOMARKERS USING POLYMERIZATION-BASED AMPLIFICATION - The invention provides methods for highly-specific detection of hybridization of single stranded nucleic acids. The invention also provides methods for target identification which rely on this highly-specific hybridization detection. Targets suitable for detection include, but are not limited to, nucleic acid biomarkers. The methods of the invention can employ an on-chip, DNA polymerase-dependent labeling scheme termed primer extension (PEX) to couple biotinylated deoxyribonucleotide triphosphate (dNTP) molecules to nucleic acid hybrids bound to a solid substrate, allowing for subsequent recognition by biotin-binding-protein-labeled photoinitiators. Surface-initiated polymerization from these surface bound photoinitiators can lead to the formation of macroscale amounts of polymeric material, thereby amplifying the signal from the initial molecular recognition event. | 05-28-2009 |
Heather Jean Avens, Lafayette, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090163375 | Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event - The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In one aspect, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another aspect, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another aspect, detectable particles can be included in the polymer formed. In another aspect, sufficient polymer forms to be detectable by visual inspection. | 06-25-2009 |
Russell Stuart Avens, Banbury GB
| Patent application number | Description | Published |
|---|---|---|
| 20100101093 | Razor With Floatably Secured Shaving Blade member - A shaving blade unit comprising a shaving cartridge having a floatably secured shaving blade member wherein said cartridge comprises: a) a housing with a front wall, a rear wall, and opposing side walls extending between said front and rear walls; b) said shaving blade member having opposing ends with a shoulder at each end and wherein said shoulder rests along said side wall and wherein a cutting edge of said shaving blade member is facing a front surface of said housing; c) a resilient member disposed rearward of said shaving blade member and that is secured by a shaving blade member retainer; and wherein said resilient member provides a forward biasing force to said shaving blade member such that said contact between said shoulder and said side wall is at least maintained when said unit is removed from a skin surface during shaving. | 04-29-2010 |
| 20100236072 | Manually Actuable Liquid Dispensing Razor - The invention features a razor for dispensing a fluid during shaving. The razor includes a razor cartridge that is engageable to a handle. The razor cartridge has a housing, a cartridge connecting structure attached to the housing; at least one blade positioned in the housing; and an aperture that extends from the rear surface to the front surface of the housing. The handle has a cavity for housing a fluid; a manually-actuated pump located along the length of the handle, and a fluid dispensing member having a channel in fluid communication with the pump and having an opening at a terminal end. The fluid dispensing member projects outwardly from the proximal end of the handle such that the terminal end extends to or adjacent to the aperture in the housing. Actuation of the pump displaces fluid from the cavity to or adjacent to the front surface of the housing. | 09-23-2010 |