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Auf Der Maur
Adrian Auf Der Maur, Rutihof CH
| Patent application number | Description | Published |
|---|---|---|
| 20090263382 | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA - The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed. | 10-22-2009 |
| 20110020220 | HUMANIZED ANTIBODIES AGAINST THE BETA-AMYLOID PEPTIDE - The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerisation of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed. | 01-27-2011 |
| 20110159008 | Antibodies Binding To The Extracellular Domain Of The Receptor Tyrosine Kinase ALK - The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma. | 06-30-2011 |
Adrian Auf Der Maur, Dietikon CH
| Patent application number | Description | Published |
|---|---|---|
| 20090311251 | SCFV ANTIBODIES WHICH PASS EPITHELIAL AND/OR ENDOTHELIAL LAYERS - scFv antibodies which specifically bind selected antigens and are obtainable by a method comprising (i) selecting from a pool of soluble and stable antibody frameworks a soluble and stable framework matching best the framework of a non-human antibody against the antigen with a certain binding specificity, (ii) either providing said soluble and stable framework with CDRs that bind specifically to said antigen, or mutating the framework of said non-human antibody towards the sequence of said soluble and stable framework, to generate scFv antibodies, (iii) testing the generated antibody for solubility and stability, and testing the generated antibody for antigen binding, and (iv) selecting an scFV that is soluble, stable and binds to the antigen specifically. Also provided are pharmaceutical compositions comprising said scFv antibody, methods of treatment and diagnosis for diseases related to over expression of antigens that are specifically bound by said antibody. | 12-17-2009 |
Adrian Auf Der Maur, Zurich CH
| Patent application number | Description | Published |
|---|---|---|
| 20080233110 | Intrabodies with defined framework that is stable in a reducing environment and applications thereof - A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies. | 09-25-2008 |
Konrad Auf Der Maur, Gossau CH
| Patent application number | Description | Published |
|---|---|---|
| 20090272630 | GRIPPER FOR HOLDING AND CONVEYING FLAT OBJECTS - A gripper for holding and conveying flat objects (P) in a firmly held manner, in particular printed material such as newspapers, magazines or brochures, includes two clamping tongues ( | 11-05-2009 |
| 20100012461 | METHOD AND DEVICE FOR CONVEYING PLANAR PRODUCTS - A method and a device for the conveyance of planar products ( | 01-21-2010 |
Konrad Auf Der Maur, Gossau Zh CH
| Patent application number | Description | Published |
|---|---|---|
| 20090195631 | METHOD AND APPARATUS FOR DISCHARGING ELECTROSTATIC CHARGE IN MULTI-LEAF PRINTED PRODUCTS - An ion nozzle ( | 08-06-2009 |