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Aspland
Mark Aspland, Berwick AU
| Patent application number | Description | Published |
|---|---|---|
| 20100050852 | DRUM - A drum having a resonant chamber for producing a range of sounds and at least one device for allowing the sound so produced to be altered, which includes a plurality of internal snares which can be brought into contact with the internal surface of the external surface of the resonant chamber which is struck by the player. The drum may also include a bass drum stick mounted within the chamber and adapted for movement to be able to selectively strike the inner surface of the drum which is struck by the player. The bass drum stick may include a pedal, or other device, operable by the player and external to the drum for effecting movement of the bass drum stick. | 03-04-2010 |
Simon E. Aspland, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090306014 | C-10 CARBAMATES OF TAXANES - Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy. | 12-10-2009 |
| 20120065165 | COMPOSITIONS AND METHODS OF TREATING ENDOTHELIAL DISORDERS - Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic combination of at least one arginase inhibitor and at least one phosphodiesterase (PDE1), (PDE2) and/or (PDE5) inhibitor are described. | 03-15-2012 |
Simon Eric Aspland, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080209587 | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination - Embodiments relate to methods of generating a genetically modified cell. The methods can include providing a primary cell containing an endogenous chromosomal target DNA sequence in which it is desired to have homologous recombination occur. The methods also can include providing a zinc finger endonuclease (ZFE) that includes an endonuclease domain that cuts DNA, and a zinc finger domain that includes a plurality of zinc fingers that bind to a specific nucleotide sequence within the endogenous chromosomal target DNA in the primary cell. Further, the methods can include contacting the endogenous chromosomal target DNA sequence with the zinc finger endonuclease in the primary cell such that the zinc finger endonuclease cuts both strands of a nucleotide sequence within the endogenous chromosomal target DNA sequence in the primary cell, thereby enhancing the frequency of homologous recombination in the endogenous chromosomal target DNA sequence. The methods also include providing a nucleic acid comprising a sequence homologous to at least a portion of said endogenous chromosomal target DNA such that homologous recombination occurs between the endogenous chromosomal target DNA sequence and the nucleic acid. | 08-28-2008 |
| 20090305402 | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination - Described herein are methods of generating a genetically modified cell by providing a zinc finger endonuclease (ZFE) that includes an endonuclease domain that cuts DNA, and a zinc finger domain that includes a plurality of zinc fingers that bind to a specific nucleotide sequence within the endogenous chromosomal target DNA in the primary cell. Further, the methods can include contacting the endogenous chromosomal target DNA sequence with the zinc finger endonuclease in the primary cell such that the zinc finger endonuclease cuts both strands of a nucleotide sequence within the endogenous chromosomal target DNA sequence in the primary cell, thereby enhancing the frequency of homologous recombination in the endogenous chromosomal target DNA sequence. | 12-10-2009 |
Simon Eric Aspland, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120065439 | SYSTEM FOR PHOTOBIOSYNTHETIC PRODUCTION, SEPARATION AND SATURATION OF CARBONACEOUS CHEMICALS AND FUELS - The present invention provides new energy solutions that are sustainable both environmentally and economically. The invention relates to photo-biocatalytic (PBC) methods and systems designed to produce and isolate carbonaceous chemicals using carbon dioxide, sunlight, and genetically engineered photosynthetic microorganisms. The PBC system comprises of procedural, mechanical and biological components designed for the production of carbonaceous chemicals. In an exemplary embodiment, the system includes a photo-biochemical reactor designed to maintain the genetically modified photosynthetic microorganisms in the optimal condition to capture carbon dioxide and convert it into metabolic intermediates using energy from sunlight, convert the metabolic intermediates into isoprene using recombinant enzymes, allow for the release of isoprene from cells, capture, separate and concentrate isoprene, and ultimately collect the isoprene at levels and in a form that would serve as a viable alternative to petroleum-dependent energy. | 03-15-2012 |