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Ashworth
Alan Ashworth, Greater London GB
| Patent application number | Description | Published |
|---|---|---|
| 20110212101 | MATERIALS AND METHODS FOR EXPLOITING SYNTHETIC LETHALITY IN MISMATCH REPAIR-DEFICIENT CANCERS - Therapeutic approaches to the treatment of DNA mismatch repair (MMR) deficient cancers are disclosed based on the use of complimentary gene-function and drug screening synthetic lethality approaches for designing therapies for the treatment of cancers where loss of tumour suppressor function has occurred. The work is based on experiments using human MSH2, an integral component of the MMR pathway, and is applicable to other genes in the MMR pathway, and in particular MLH1, MSH6, PMS1 and PMS2. In particular loss of MSH2 is synthetically lethal with inhibition of the DNA polymerase POLβ deficiency of MLH1 is synthetically lethal with DNA polymerase γ (POLG) inhibition. | 09-01-2011 |
Alan Ashworth, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20080200469 | PHTHALAZINONE DERIVATIVES - Compounds of the formula (I): | 08-21-2008 |
Doreen M. Ashworth, Southampton GB
| Patent application number | Description | Published |
|---|---|---|
| 20080255126 | Inhibitors of post-proline cleaving proteases - Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R | 10-16-2008 |
Doreen Mary Ashworth, Southampton GB
| Patent application number | Description | Published |
|---|---|---|
| 20080261951 | Condensed azepines as vasopressin agonists - This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V | 10-23-2008 |
Ian Woodward Ashworth, Macclesfield GB
| Patent application number | Description | Published |
|---|---|---|
| 20090270617 | PHTHALAZINONE DERIVATIVE - 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A. | 10-29-2009 |
John Ashworth, County Dublin IE
| Patent application number | Description | Published |
|---|---|---|
| 20110050257 | Moisture meter - A moisture meter ( | 03-03-2011 |
Judy Ashworth, Wermelskirchen DE
| Patent application number | Description | Published |
|---|---|---|
| 20080311187 | CRUSH RESISTAN DELAYED-RELEASE DOSAGE FORM - The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substances (A) from the dosage form is at least partially delayed. | 12-18-2008 |
Judy Ashworth, Aachen DE
| Patent application number | Description | Published |
|---|---|---|
| 20100151028 | CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS - The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed. | 06-17-2010 |
Lindsey Louise Ashworth, Romsey GB
| Patent application number | Description | Published |
|---|---|---|
| 20100004917 | USE OF DEFINING IGNORABLE RECTANGLES TO ASSIST WITH ITERATIVE TRANSLATION TESTING - The example embodiments relate to a method for assisting in the translational testing of computer software. A translated panel, which may include a translatable portion and a continuously dynamic portion, may be provided. An overlay that includes only the continuously dynamic portions of the panel may be produced. The overlay may be applied to first and second versions of the panel to produce first and second iterations of the panel, respectively, wherein each iteration does not include the continuously dynamic portion of the panel. The translatable portions of the first and second iterations may be compared to determine whether the translatable portions are different. If the translatable portions are different, then the panel may be retested for translational accuracy; if the translatable portions are not different, then the program may indicate that the second iteration is not different from the first iteration. | 01-07-2010 |
Pauline Ashworth, Toronto CA
| Patent application number | Description | Published |
|---|---|---|
| 20100288297 | APPLICATOR - An applicator is provided with a volume for receiving one or more disposable or refillable container containing a hair treatment composition. The applicator is provided with opposed arms that are configured such that, when the arms are brought towards each other, the hair treatment composition is dispensed. | 11-18-2010 |
Terence Ives Ashworth, Guernsey GB
| Patent application number | Description | Published |
|---|---|---|
| 20090139919 | PARTICLE SEPARATION ASSEMBLY - A particle separation assembly comprises a vessel provided with an inlet, a first outlet and a second outlet. The assembly is arranged such that the flow rate of fluid through the inlet is greater than the flow rate of fluid through the first outlet such that there is a resultant fluid flow of lighter particles up the vessel and through the second outlet. Flow adjustment means are provided to enable the velocity of this resultant fluid flow to be adjusted, said means comprising a pivotable flap in one example. | 06-04-2009 |