Ascenzi
Maria-Grazia Ascenzi, Santa Monica, CA US
Patent application number | Description | Published |
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20090310833 | Determining Orientation of Cilia in Connective Tissue - The present invention provides methods and apparatus for determining an orientation of a cilium relative to a characteristic of the shape of the cell from which the cilium projects. Three-dimensional microscopy data may be used to determine an orientation of a cilium relative to a specified axis, which is determined from a profile for each cell. Such orientation may be used to forecast alter, or otherwise study the growth process of chondrocytes. Results indicate that the shape of chondrocytes, the position of the ciliary basal body, the incidence of cilia, and the orientation of cilium, are not random through the growth plate. | 12-17-2009 |
20110022370 | METHOD AND SYSTEM FOR MODELING BONE STRUCTURE FROM COLLAGEN BUNDLE ORIENTATIONS - The present invention relates to the characterization of human bone microstructure that is applicable to methods of characterizing and predicting fracture initiation, propagation, and arrest. These methods involve the collagen orientation in proximity of osteocyte lacunae, such as the lacunar-ECM interface and perilacunar region, and the role that collagen orientation plays in micro-biomechanics. In particular, collagen orientation at the lacuna-matrix interface optimizes the magnitude of stresses during the elastic phase. Further, the role of collagen-apatite orientation at the interface between matrix and osteocyte lacuna delays micro-crack initiation, propagation, and arrest. | 01-27-2011 |
Maria-Grazia Ascenzi, Los Angeles, CA US
Patent application number | Description | Published |
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20080208550 | Method and System for Modeling Bone Structure - The present invention relates to scanning confocal microscopy used to systematically quantify characteristic collagen fibril orientations by position within the lamellar thickness of secondary osteons along the osteon radial direction. Fully calcified lamellar specimens appear either extinct or bright in cross-section under circularly polarized light, and can be isolated from embedded osteon, flattened, and examined along the radial thickness direction of the original embedded osteon. Collagen orientation is measured from confocal image stacks. Extinct and bright lamellae display distinct patterns of collagen orientation distribution. Relative counts of collagen fibrils that are longitudinal to the osteon axis in extinct lamellae, transverse to the osteon axis in bright lamellae, and oblique to the osteon axis in both lamellar types, show parabolic distribution through the osteon radial direction. | 08-28-2008 |
Robert Ascenzi, Gary, NC US
Patent application number | Description | Published |
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20100043102 | Nematode Inducible Promotors and Methods of Use - The invention provides promoter polynucleotides that are root-specific and/or induced by parasitic nematodes. The promoters of the invention are useful for controlling expression of nucleic acids of interest in plant roots. | 02-18-2010 |