Patent application number | Description | Published |
20080207527 | Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof - The present invention provides bicyclic beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. | 08-28-2008 |
20100041619 | Lasonolide compounds as reagents for inducing premature chromosome condensation and methods for treating disorders - The present invention is directed towards lasonolide derivatives, methods of inducing premature chromosome condensation using lasonolide derivatives, and methods of treating disorders, such as cancer, in a subject, the method comprising administering to the subject a lasonolide derivative. | 02-18-2010 |
20100113582 | METHODS AND COMPOSITIONS FOR TREATING HIV INFECTIONS - Described herein are compounds and compositions that are useful in the treatment of HIV, AIDS, and AIDS-related diseases. In addition, compounds are described herein that are capable of inhibiting the dimerization of HIV proteases. | 05-06-2010 |
20100267609 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF - Compounds inhibit memapsin 2 β-secretase activity and selectively inhibit memapsin 2 β-secretase activity relative to memapsin 1 β-secretase activity. The compounds are employed in methods to inhibit memapsin 2 β-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a β-secretase site of a β-amyloid precursor protein and to decrease β-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized. | 10-21-2010 |
20100286145 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY - The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. | 11-11-2010 |
20100286170 | (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING - The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. | 11-11-2010 |
20110046199 | SMALL MOLECULE INHIBITORS OF HIV PROTEASES - Described herein are compounds, compositions, and methods for treating HIV and related diseases. | 02-24-2011 |
20110118330 | HIV PROTEASE INHIBITORS AND METHODS FOR USING - Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described. | 05-19-2011 |
20110178123 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS - Novel compounds and compositions for treating patients in need of relief from HIV, AIDS, and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described. | 07-21-2011 |
20110195978 | COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE - Described herein are compounds, and pharmaceutical compositions, methods, and uses thereof for treating Alzheimer's disease. | 08-11-2011 |
20110230505 | QUINAZOLINE INHIBITORS OF BACE 1 AND METHODS OF USING - Dihydroquinazoline compounds, compositions containing them, the use of the compounds and compositions for the treatment of Alzheimer's disease are described. | 09-22-2011 |
20110269834 | COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES - Described herein are compounds and compositions, and methods for using the compounds and compositions, for treating respiratory diseases and illness, such as severe acute respiratory syndrome (SARS). | 11-03-2011 |
20110275619 | INHIBITORS OF BACE1 AND METHODS FOR TREATING ALZHEIMER'S DISEASE - Inhibitors of BACE1 and compositions containing them are described. Use of the inhibitors and compositions containing them to treat Alzheimer's disease are described. | 11-10-2011 |
20120059161 | COMPOUNDS AND METHODS FOR TREATING AIDS AND HIV INFECTIONS - Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described. | 03-08-2012 |
20120214802 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF - Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease. | 08-23-2012 |
20120295894 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF - Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease. | 11-22-2012 |
20130102593 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF - Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease. | 04-25-2013 |
20130158094 | FUSED TRICYCLIC ETHER CARBAMATES AND THEIR USE - Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described. | 06-20-2013 |
20130289067 | COMPOUNDS AND METHODS FOR TREATING HIV - Inhibitors of HIV-1 protease and compositions containing them are described. Use of the inhibitors and compositions containing them to treat HIV, AIDS, and AIDS-related diseases is described. | 10-31-2013 |
20130338380 | PROCESSES AND INTERMEDIATES FOR PREPARING SUBSTITUTED HEXAHYDROFURO [2,3-b] FURANS - The invention described herein pertains to processes and compounds useful in the preparation of bis-tetrahydrofurans. The invention described herein also pertains to compounds useful for treating HIV infections. | 12-19-2013 |
20140066488 | Inhibitors of Memapsin 2 Cleavage for the Treatment of Alzheimer's Disease - Proteases such as memapsin 2 are important enzymes, playing roles in a variety of diseases including Alzheimer's Disease. The inventors have developed inhibitors of memapsin 2 and methods of use therefore in the treatment of disease. | 03-06-2014 |
20140135321 | SMALL MOLECULE INHIBITORS OF HIV PROTEASES - Described herein are compounds, compositions, and methods for treating HIV and related diseases. | 05-15-2014 |
20140148508 | C-3 SUBSTITUTED BICYCLOOCTANE BASED HIV PROTEASE INHIBITORS - C3-functionalized-cyclopentanyltetrahydrofuranyl carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are described. Compositions comprising the disclosed compound and methods of using the compounds and/or compositions for treating patients infected with HIV are also described. | 05-29-2014 |
20140179754 | FUSED TRICYCLIC ETHER CARBAMATES AND THEIR USE - Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described. | 06-26-2014 |
20140221420 | CCR5 ANTAGONISTS FOR TREATING HIV - Compounds that modulate the CCR5 chemokine receptor, pharmaceutical compositions containing them, and uses therefor in the treatment of HIV and related diseases are described. | 08-07-2014 |
20140315946 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS - Novel compounds and compositions for treating patients in need of relief from HIV, AIDS and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described. | 10-23-2014 |
20150072958 | HIV-1 PROTEASE INHIBITORS HAVING GEM-DI-FLUORO BICYCLIC P2-LIGANDS - Various embodiments of the present invention relate to, among other things, compounds and methods of using those compounds to treat an HIV infection. The compounds of the various embodiments of the present invention provide, among other things, therapeutic agents having enhanced penetration capability across the blood-brain barrier, such that they can enter the CNS to treat an HIV-1 infection in the CNS. | 03-12-2015 |
20150080439 | COMPOUNDS FOR INHIBITION OF MEMAPSIN 1 - Various embodiments of the present invention relate to, among other things, compounds that are inhibitors of Memapsin 1 and, as a result, are effective in the treatment of Alzheimer's disease or diabetes (e.g., Type 2 diabetes). | 03-19-2015 |