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Arumugham
Rangaswamy Arumugham, Richardson, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20080256379 | Clock architecture for multi-processor systems - In one embodiment, a computer system, comprises at least a first computing cell and a second computing cell, each computing cell comprising at least one processor, a routing device to couple the first and second computing cells, a global clock signal source coupled to the at least two computing cells to generate a global clock signal, at least one timing manager to generate a timing control signal, wherein the at least two computing cells comprise a local oscillator to generate a local clock signal, and a multiplexer coupled to receive the global clock signal, the local clock signal, and the timing control signal, and to output one of the global clock signal or the local clock signal in response to the control signal. | 10-16-2008 |
Rangaswamy Arumugham, Plano, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20120117415 | PROVIDING FAULT-TOLERANT SPREAD SPECTRUM CLOCK SIGNALS IN A SYSTEM - To provide fault-tolerant, spread spectrum clock signals, a plurality of processing modules having respective spread spectrum control circuits are provided. Clock signals of redundant clock sources are provided to the plurality of processing modules. Failover control logic selects a corresponding one of the clock signals from the redundant clock sources for use in each of the processing modules. Frequency spreading is applied to the corresponding selected clock signal in each of at least some of the plurality of processing module. | 05-10-2012 |
Rasappa Arumugham, Pittsford, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090285844 | NON-TOXIC MUTANTS OF PATHOGENIC GRAM-NEGATIVE BACTERIA - A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation. | 11-19-2009 |
Rasappa Arumugham, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080227207 | AUTOMATED COLORIMETRIC POLYSACCHARIDE ASSAYS - A method of automated determination of saccharide concentration is provided herein. The method includes preparing one or more saccharide standards and one or more diluted polysaccharide test samples, transferring a portion of the one or more saccharide standards and the one or more diluted polysaccharide test samples along with a diluent to a series of wells in a multiwell plate, transferring a portion of an acid reagent to the series of wells in the multiwell plate, mixing the contents of the series of wells in the multiwell plate, heating and cooling the contents of the series of wells in the multiwell plate, shaking the multiwell plate, and measuring the radiant energy absorbance of the contents of the series of wells in the multiwell plate, where all steps are performed in the absence of human intervention. | 09-18-2008 |
Rasappa G. Arumugham, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080299074 | A-BETA IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME - The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods. | 12-04-2008 |
| 20110287042 | A-Beta Immunogenic Peptide Carrier Conjugates and Methods of Producing Same - The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods. | 11-24-2011 |