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Arnould, FR
Cyrille Arnould, Montoy-Flanville FR
| Patent application number | Description | Published |
|---|---|---|
| 20120073457 | AGRICULTURAL RAM PRESS - An agricultural ram press has a bale chamber, a baling ram moveable in an oscillating manner in the bale chamber, a feed channel, a feed rake arranged in the feed channel and switchable between a gathering stroke motion which compresses crop in the feed channel and a filling stroke motion which moves the crop from the feed channel into the bale channel, and a drive for driving the feed rake and having a control rod interacting with an adjustable stop to control at least one of the motions of the feed rake. | 03-29-2012 |
Jean Claude Arnould, Reims FR
| Patent application number | Description | Published |
|---|---|---|
| 20090062267 | L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS - The present invention relates to compounds that inhibit a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to compounds that inhibit a5b1, and also that exhibit appropriate selectivity profile(s) against other integrins. | 03-05-2009 |
| 20090203663 | CHEMICAL COMPOUNDS - The present invention relates to compounds that inhibit a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to compounds that inhibit a5b1, and also that exhibit appropriate selectivity profile(s) against other integrins. | 08-13-2009 |
Jean-Claude Arnould, Reims Cedex 2 FR
| Patent application number | Description | Published |
|---|---|---|
| 20080255183 | N-[HETEROARYLCARBONYL]-3-THIENYL-L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS - The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to a5b1 antagonists that also exhibit appropriate selectivity profile(s) against other integrins. | 10-16-2008 |
Jean-Claude (retired) Arnould, Reims FR
| Patent application number | Description | Published |
|---|---|---|
| 20090076009 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS - The invention concerns thiazole derivatives of Formula I | 03-19-2009 |
Laurent Arnould, Dijon FR
| Patent application number | Description | Published |
|---|---|---|
| 20110189185 | Method for Predicting Responsiveness to a Treatment With an Anti-HER2 Antibody - The invention provides an in vitro method for predicting whether a patient would be responsive to a treatment with an anti-HER2 blocking agent, such as trastuzumab, which method comprises determining the expression level of at least 4 genes in a biological sample of said patient, wherein said genes are GPR22, PEX19, GRHL2 and DERL1. The invention further provides a DNA chip for performing such method. | 08-04-2011 |
Robert Arnould, Cedex FR
| Patent application number | Description | Published |
|---|---|---|
| 20100277018 | DEVICE FOR THE CONTACT AND ATTACHMENT OF AN ELECTRIC COMPONENT IN A MOTOR VEHICLE - A device is provided for contact and attachment of an electrical component, such as in a motor vehicle. The contact and attachment are in a substantially flat region of a support element. The device comprises a plurality of clips. One side of the clips being configured to be at least partially inserted into at least one recess in the support element. | 11-04-2010 |
Robert Arnould, Sardon FR
| Patent application number | Description | Published |
|---|---|---|
| 20100157431 | DISPLAY DEVICE - The invention relates to a display device, particularly for an automotive vehicle, that comprises an unfolding member ( | 06-24-2010 |
Sylvain Arnould, Saint-Denis FR
| Patent application number | Description | Published |
|---|---|---|
| 20090222937 | MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM A XERODERMA PIGMENTOSUM GENE AND USES THEREOF - An I-CreI variant which has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG (SEQ ID NO: 229) core domain situated from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from a xeroderma pigmentosum gene. Use of said variant and derived products for the prevention and the treatment of Xeroderma pigmentosum. | 09-03-2009 |
| 20090271881 | MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM A RAG GENE AND USES THEREOF - An I-CreI variant, wherein one of the I-CreI monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated respectively from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from a RAG gene. Use of said variant and derived products for the prevention and the treatment of a SCID syndrome associated with a mutation in a RAG gene. | 10-29-2009 |
| 20100151556 | HYBRID AND SINGLE CHAIN MEGANUCLEASES AND USE THEREOF - This patent application relates to hybrid and/or single-chain rare-cutting endonucleases, called meganucleases, which recognize and cleave a specific nucleotide sequence, to polynucleotide sequences encoding for said rare-cutting endonucleases, to a vector comprising one of said polynucleotide sequences, to a cell or animal comprising one of said polynucleotide sequences or said rare-cutting endonucleases, to a process for producing one of said rare-cutting endonucleases and any use of the disclosed products and methods. More particularly, this invention contemplates any use of such rare-cutting endonuclease for genetic engineering and gene therapy. | 06-17-2010 |
Sylvain Arnould, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20100144012 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide. | 06-10-2010 |
| 20110151539 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide. | 06-23-2011 |
| 20110287513 | USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF - A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide. | 11-24-2011 |