Patent application number | Description | Published |
20100240970 | METHOD FOR AN IN VIVO MEASUREMENT USING A DEVICE IMPLANTED IN A PATIENT, AND CORRESPONDING DEVICE - An embodiment of the present invention relates to a device, which can be implanted into a patient, for an in vivo measurement. In an embodiment, the device includes a catheter for guiding a sample of the patient town analysis unit in the device. A measurement result is determined in the analysis unit by analyzing the sample with the aid of a reagent. In an embodiment, the device furthermore includes an interchange chamber, with the aid of which the reagent can be removed from the device or can be inserted into the device. The interchange chamber has a connector allowing removal or insertion of the reagent while the device is implanted. | 09-23-2010 |
20100247438 | IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES - An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor. | 09-30-2010 |
20100329977 | METHOD FOR IMAGING TUMOR TISSUE - A method is disclosed for imaging a tumor tissue, wherein in at least one embodiment a) the tumor tissue is contacted with a monoclonal antibody, an antigen-binding fragment thereof, a recombinant binding protein, an aptamer, or other molecule, each of which recognizes and binds at least one neoepitope which has been generated by proteolytic cleavage of proteins surrounding the tumor tissue by tumor-specific proteases, and b) the complexes formed from neoepitope and monoclonal antibody, antigen-binding fragment thereof, recombinant binding protein, aptamer, or other molecule are depicted with an imaging method, and also to neoepitopes generated by proteolytic cleavage of surrounding proteins by tumor-specific proteases, and also proteins or peptides for generating neoepitopes by tumor-specific proteases. | 12-30-2010 |
20110046455 | METHODS AND DEVICES FOR EXAMINING A PARTICULAR TISSUE VOLUME IN A BODY, AND A METHOD AND A DEVICE FOR SEGMENTING THE PARTICULAR TISSUE VOLUME - A tip of an elongate device is navigated into a particular tissue volume in order to examine the particular tissue volume in a body and part of the tissue volume is analyzed in real-time by way of a biosensor. In at least one embodiment, in the process, either the biosensor can be arranged on the tip of the device or the device includes a catheter, by which a substance to be analyzed is transported out of the tissue volume from the tip to the biosensor arranged at the proximal end of the catheter. | 02-24-2011 |
20110046893 | METHOD FOR NORMALIZING THE RESULTS OF AN IN-VITRO ANALYTICAL METHOD - A method is disclosed for normalizing the results of an in-vitro analytical method for one or more diagnostically and/or prognostically relevant substances in an organism (biomarker) or one or more substances supplied to an organism from the outside. In at least one embodiment of the method a) one or more concentration values of the substance(s) in an organism, said concentration value(s) being obtained in an in-vitro analytical method is (are) provided, b) data obtained from an imaging study of the same organism are provided, c) from the data according to b), one or more quantitative values are determined as imaging value(s), d) from the values according to a) and c), one or more diagnostic parameters are determined by relating the values according to a) and c) to one another, and also to the use of this method for the type-correct dosage finding of drugs and for the in-vitro diagnosis, prognosis and monitoring the course of a disease. In addition, at least one embodiment of the invention relates to a program for a data processing system which, when carried out in a suitable computer system, carries out the above method, and also to an electronically readable data carrier having electronically readable control information stored thereon, which control information is configured in such a manner that they carry out the above method when a suitable data carrier is used in a suitable computer system. | 02-24-2011 |
20110150758 | TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING - At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method. | 06-23-2011 |
20110224533 | Element That Can Be Fixed In A Blood Vessel And Is Provided With Biomarkers - An element is disclosed that can be fixed in a blood vessel of a living being has a base body to which a first substance and/or a second substance is/are applied at least in parts. In at least one embodiment, the first substance is determined in such a way that it can be detected from outside of the body of the living being by way of a first non-invasive detection method and reacts with at least one first biochemical substance that is released by the living being into the blood vessel during a first pathological condition of the living being, with the result that the quantity of first substance applied to the base body is reduced. The second substance is determined in such a way that it binds at least one second biochemical substance that is released by the living being into the blood vessel during a second pathological condition of the living being and the presence of the bound substance can be detected from outside of the body of the living being by way of a second non-invasive detection method. | 09-15-2011 |
20110229414 | Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients - A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition site for at least one tumor-specific protease, wherein a hyperpolarization site is located at the N and/or C terminus of the substrate, and wherein the linker is configured such that the hydrophobic ends of the substrate interact and form a central core by means of noncovalent interactions with the lipophilic residues, and the contrast agent together with a parahydrogen metal template for use in an imaging method for diagnosing a tumor. At least one embodiment of the invention further relates to a method for imaging a tumor tissue, wherein the above-described contrast agent accumulated in a tumor tissue is imaged using a suitable imaging method after hyperpolarization by way of contact with a parahydrogen metal template, and also to a method for imaging a tumor tissue in a patient, wherein a) a contrast agent as described above is administered to a patient, b) a parahydrogen metal template is administered to the patient, and c) the presence of a tumor is depicted using an imaging method. | 09-22-2011 |
20130320975 | METHOD AND DEVICE FOR DETERMINING A CHANGE OVER TIME IN A BIOMARKER IN A REGION TO BE EXAMINED - A method for determining a change over time in a biomarker in a region to be examined of a patient is provided. The change is determined from magnetic resonance data using a magnetic resonance measuring system with sequences and protocols for measuring the biomarkers by functional resting state connectivity by rsfMRI, perfusion values, magnetic resonance spectra of voxels, or morphometry of organs. A control unit has programs which evaluates the biomarker and a data memory which stores the results of the evaluation and additional data. During a first examination, a quantity result of the biomarkers is determined and stored in the data memory. During a follow-up examination, at least one previous item of the result and additional data from the first examination stored in the data memory are used for determining a quantitative change in the biomarker. | 12-05-2013 |