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Arnalot Aguilar

Carme Arnalot Aguilar, Girona ES

Patent application numberDescriptionPublished
20090076281PROCESS FOR THE PREPARATION OF LOSARTAN AND ITS SALTS - The invention relates to the preparation of losartan and losartan potassium. More particularly, the invention relates to the preparation of losartan and losartan potassium in a simplified process that provides higher purity losartan potassium and losartan potassium having larger crystal sizes. The invention further includes formulating into readily usable dosage units for the therapeutic treatment (including prophylactic treatment) of mammals, including humans.03-19-2009

Carme Arnalot Aguilar, Barcelona ES

Patent application numberDescriptionPublished
20080214816Process for Preparing Ziprasidone - Process for preparing ziprasidone. The present invention concerns a process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one of the formula I, or a pharmaceutically acceptable acid addition salt, solvate, hydrates or clathrate thereof, said process comprising reacting a compound of formula II wherein X is a halogen atom, with a compound of formula III, said compound of formula III being the free base or an addition salt with an organic or inorganic acid, wherein said process is characterized in that said compounds according to formulas II and III are reacted in the presence of a neutralizing agent, and are reacted in a solvent comprising acetonitrile.09-04-2008

Carmen Arnalot Aguilar, Girona ES

Patent application numberDescriptionPublished
20090043126Process and Methods for the Preparation of Gabapentin and Its Intermediates - The invention provides a process for preparing gabapentin and its intermediates. The process generally involves treating gabapentin lactam with an aqueous solution of hydrobromic acid to yield gabapentin hydrobromide salt as an intermediate, which can be isolated by filtration. The gabapentin hydrobromide salt can then be hydrolyzed with a base, such as an organic amine, to yield gabapentin that can be isolated by filtration.02-12-2009
20090247542SYNTHESES AND PREPARATIONS OF POLYMORPHS OF CRYSTALLINE ARIPIPRAZOLE - The invention relates to polymorphic crystalline forms of aripiprazole, synthetic processes for their preparation and pharmaceutical compositions containing the same. These crystalline forms of aripiprazole can be readily milled and can be easily combined with various pharmaceutical adjuvants without effecting changes to their crystalline structure when, for example, pressed into tablet or capsule form.10-01-2009
20090247642SYNTHESIS AND PREPARATIONS OF METOPROLOL AND ITS SALTS - The invention relates to an improved process for preparing metoprolol and its salts.10-01-2009

Carmen Arnalot Aguilar, Barcelona ES

Patent application numberDescriptionPublished
20080207896Process For the Manufacture of Mirtazapine - Improved process for manufacturing mirtazapine. A process is described for preparing mirtazapine starting from a compound of formula (II), which is subjected to a ring cyclization, obtaining mirtazapine for pharmaceutical use in crystalline and anhydrous form.08-28-2008