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Appella
Daniel Appella, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100303719 | ANTI-CANCER COMPOUNDS - The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation. | 12-02-2010 |
Daniel H. Appella, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080206805 | Compounds and Related Methods for Mutant p53 Reactivation - Ketoamine compounds and related methods for reactivation of tumor suppressor protein p53. | 08-28-2008 |
| 20100120031 | SYNTHESIS OF TRANS-TERT-BUTYL-2-AMINOCYCLOPENTYLCARBAMATE - The present invention concerns methods of synthesis of trans-tert-butyl-2-aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN | 05-13-2010 |
Ettore Appella, Chevy Chase, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090074724 | MATERIALS AND METHODS FOR INHIBITING WIP1 - Isolated or purified oligonucleotides and isolated or purified morpholino oligomers; a method of detecting cancer or a predisposition to cancer in a mammal, comprising comparing the level of expression of Wip1 in the mammal to a control; a method of treating cancer in a mammal that expresses the same or a higher level of Wip1 as compared to a mammal of the same species that does not have cancer, comprising administering to the mammal a cancer-treating effective amount of a Wip1 inhibitor; a method of screening an oligonucleotide or morpholino oligomer for the ability to inhibit the expression of Wip1; a method of determining the efficacy with which a test oligonucleotide or morpholino oligomer inhibits Wip1 expression; a method of screening a compound for Wip1-inhibiting activity; and a method of determining the efficacy with which a test compound inhibits Wip1. | 03-19-2009 |
| 20090247473 | ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS - Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins. | 10-01-2009 |