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Aotsuka

Mizuho Aotsuka, Tokyo JP

Patent application numberDescriptionPublished
20100014983TURBINE BLADE - The present invention provides a turbine blade that is exposed to a high temperature atmosphere at relatively high temperatures and to a low temperature atmosphere at relatively low temperatures, including: a concave-curve-like pressure surface that is concaved along a flow direction of fluid; a convex-curve-like suction surface that is convexed along the flow direction of the fluid; and a concave and convex formation device which causes a concave and convex portion along the flow of the fluid to appear on the suction surface when the turbine blade is exposed to the low temperature atmosphere, and which turns the suction surface into a smooth surface along a convex curve surface of the suction surface when the turbine blade is exposed to the high temperature atmosphere. With this construction, it is possible to reduce a pressure loss of the turbine blade at high Reynolds numbers in the low temperature atmosphere without increasing a pressure loss of the turbine blade at low Reynolds numbers in the high temperature atmosphere.01-21-2010

Tomoji Aotsuka, Hamura JP

Patent application numberDescriptionPublished
20100093782Pyrazolonaphthyridine derivatives - The target is to provide PDE IV inhibitors which have a highly potent anti-asthmatic and/or COPD-prophylactic/therapeutic profile with unexpectedly excellent safety. A compound of the formula (1):04-15-2010

Patent applications by Tomoji Aotsuka, Hamura JP

Tomoji Aotsuka, Hamura-Shi JP

Patent application numberDescriptionPublished
20090131467Heterocycle Compound, and Production Process and Application Thereof - The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group (e.g., a carbocycle and a heterocycle) bonding through an alkylene group at 3-position and a carbocycle bonding at 5-position and has a phosphodiesterase IV inhibitory activity. At least one of the ring (the carbocycle or the heterocycle) bonding at 3-position of the pyrazolonaphthyridine skeleton and the carbocycle bonding at 5-position may have a halogenated alkyl group and/or a halogenated alkoxy group as a substituent. Such a compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and the like. According to the present invention, a novel compound having a high phosphodiesterase IV inhibitory effect can be provided.05-21-2009
20100056613SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION - A novel spiroquinone derivative having a high ABCA1 stabilization effect and being useful for prophylactic and/or therapeutic agents for various diseases developing hypo-high density lipoproteinemia is obtained. The novel spiroquinone derivative is a compound represented by the following formula:03-04-2010