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Antonis
Antonis Kourtidis, Saint Augustine, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100261776 | BRUTON'S TYROSINE KINASE AS ANTI-CANCER DRUG TARGET - Receptor protein tyrosine kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating the formation of complexes that regulate key cellular functions. Over half of the 90 tyrosine kinases have been implicated in human cancers and are for this reason considered highly promising drug targets. To gain insight into the tyrosine kinases that contribute to breast cancer related cellular mechanisms, we carried out a large-scale loss-of-function analysis of the tyrosine kinases, using RNA interference, in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line. The cytosolic, non-receptor tyrosine kinase Bruton's tyrosine kinase (BTK), which has been extensively studied for its role in B cell development, was among those tyrosine kinase genes required for BT474 breast cancer cell survival. The BTK protein identified was an alternative form containing an amino-terminal extension. This alternative form of the Btk message is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. | 10-14-2010 |
| 20100267803 | Regulators Of Fat Metabolism As Anti-Cancer Targets - Embodiments of the invention provide methods of identifying agents that reduce or prevent the proliferation of breast cancer cells, or kill them, in particular by interfering with the expression of the transcription factors NR1D1 and PPARĪ³ or the expression of genes whose transcription they activate or the activity of the proteins translated from those transcripts. | 10-21-2010 |
Antonis Panteleon, Edina, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110060380 | RESPIRATORY RECTIFICATION - A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied. | 03-10-2011 |
Antonis Paravantsos, Thessaloniki GR
| Patent application number | Description | Published |
|---|---|---|
| 20100208455 | ROTATABLE REFLECTOR SUPPORT SYSTEM - Disclosed is a system for the support and rotation of a reflector onto a body of a fluorescent luminary. The luminary body has first and second longitudinal ends along an axis. The rotatable reflector support system comprises an elongated reflector having first and second longitudinal ends. The reflector has first and second arch-shaped fittings proximate to the first and second reflector ends, respectively. First and second bases are mounted on the luminary body proximate the first and second ends of the body, respectively. The side of each base facing the lamp, when the lamp is mounted in the luminary, is shaped to engage a plurality of serial portions of an associated arch-shaped fitting in a manner allowing serial portions of the fitting, when manipulated, to slide along an arch-shaped path transverse to said axis and to hold the fitting in place when the fitting is not manipulated. | 08-19-2010 |
Antonis Tsakotellis, Neuchatel CH
| Patent application number | Description | Published |
|---|---|---|
| 20110100384 | THERMALLY INSULATIVE SMOKING ARTICLE FILTER COMPONENTS - A filter component includes a catalyst surrounded by a thermally insulative carbon fiber composite. The catalyst can catalyze the chemical reaction of selected gaseous constituents of a gas stream. During catalysis, the catalyst can reach high temperatures. The carbon fiber composite can contain heat generated during the catalysis within the filter component and thereby reduce heat transfer to the surroundings. The filter component can be used in smoking articles. Methods of making and using the filter-component and methods for treating mainstream tobacco smoke are also provided. | 05-05-2011 |
Antonis Zervos, Oviedo, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100311772 | METHOD AND COMPOUNDS FOR INHIBITION OF CELL DEATH - The invention is directed to methods and compositions for inhibiting caspase-independent apoptosis. In particular, methods and compositions for inhibiting Omi/HtrA2 activity, as well as method for identifying other inhibitors of Omi/HtrA2. Also disclosed are Omi/HtrA2 specific substrates and methods for identifying other substrates of Omi/HtrA2. | 12-09-2010 |