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Annemieke
Annemieke Aartsma-Rus, Leiden NL
| Patent application number | Description | Published |
|---|---|---|
| 20090312532 | Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secodary rna structure - The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the binding of an SR protein and/or methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA. | 12-17-2009 |
Annemieke Aartsma-Rus, Hoofddorp NL
| Patent application number | Description | Published |
|---|---|---|
| 20090269755 | MEANS AND METHOD FOR INDUCING EXON-SKIPPING - In the present invention means and method are provided for optimising exon-skipping using exon-internal AON. We show that skipping efficiencies are improved by targeting putative splicing regulatory sequences (ESEs) within an exon. Such double targeting may be particularly useful for exons with which efficient skipping was difficult to obtain prior to the invention. | 10-29-2009 |
Annemieke Van De Runstraat, Zoetermeer NL
| Patent application number | Description | Published |
|---|---|---|
| 20110112216 | PROCESS AND APPARATUS FOR CARRYING OUT MULTI-PHASE REACTIONS - The invention is directed to a process and apparatus for carrying out reactions with reaction mixtures comprising different physical phases. In a first aspect, the present invention is directed to a process for carrying out chemical reactions comprising a step wherein a reaction mixture comprising at least two different physical phases, wherein at least one of these phases being liquid, is subjected to the action of Dean vortices, which Dean vortices result from said liquid flowing through a channel having at least two curvatures, wherein the channel comprises for at least a fraction of its total length a smooth inner surface. | 05-12-2011 |
Annemieke Verstuyf, Oud-Heverlee BE
| Patent application number | Description | Published |
|---|---|---|
| 20100160455 | VITAMIN D3 ANALOGUES FOR THE PREVENTION AND TREATMENT OF BONE DISORDERS - Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis | 06-24-2010 |