Patent application number | Description | Published |
20130065771 | Apparatus and method for parallel collection and analysis of the proteome and complex compositions - This invention relates to a kit and a method for the collection and analysis of complex protein mixtures. More particularly, the invention relates to a kit comprising a single barrel filtration well or a multi-well filtration plate wherein each well comprises an upper filtration zone; a lower filtration zone; a conical flow director zone; and, an elution tip, wherein the upper filtration zone and the lower filtration zone are separated by a retainer ring disposed within the lower filtration zone. The upper filtration zone comprises an upper collection zone, a sponge zone, and a deep bed filtration zone; and, the lower filtration zone comprises the retainer ring, a supported hydrophilic membrane and a lower bed filtration media. When used with an array of selected buffer solutions, the multi-well filtration plate can provide accurate, automated, high-throughput protein analysis by affinity chromatography. | 03-14-2013 |
20130316412 | FERMENTATION AND SIMULATED MOVING BED PROCESS - The invention provides an improved method for the production, separation and recovery of one or more fermentation products from a fermentation broth. Further, the invention provides a method for increasing efficiency of a fermentation reaction. In particular, the invention relates to a fermentation system which incorporates a simulated moving bed for separation of fermentation products from a fermentation broth, and a corresponding method | 11-28-2013 |
20130317210 | Tagatose production using simulated moving bed separation - Disclosed is a process for the production of d-tagatose from lactose after acid hydrolysis to provide a hydrolysate having 1 equiv of d-glucose and 1 equiv of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose as two products from lactose hydrolysate. In an alternate embodiment, a process is disclosed for the production of d-tagatose from fermented lactose hydrolysate to provide a crystallized d-tagatose product. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant. | 11-28-2013 |
20130317260 | PROCESS AND ADSORBENT FOR SEPARATING ETHANOL AND ASSOCIATED OXYGENATES FROM A BIOFERMENTATION SYSTEM - Disclosed is a process and an adsorbent for the separation of ethanol associated oxygenates from a dilute mixture of ethanol and associated oxygenates in water in the presence of organic compounds derived from a biofermentation process. After pretreatment, the separation is carried out in a simulated moving bed adsorption system employing an stationary phase adsorbent comprising fluorinated carbon or modified C18 silica gel selective for the adsorption of ethanol and associated oxygenates, such as 2,3-butanediol, with a mobile phase desorbent selected from the group consisting of methanol, ethanol, propanol, and methyl tertiary butyl ether. The process is useful for removing water from dilute aqueous mixtures of organic compounds comprising ethanol in dilute concentration in water and produced by fermentation, biomass extraction, biocatalytic and enzymatic processes which are not economically recoverable by conventional distillation methods. | 11-28-2013 |
20140039180 | MANNOSE PRODUCTION FROM PALM KERNEL MEAL USING SIMULATED MOVING BED SEPARATION - Disclosed is a process for the production of d-mannose from fermented palm oil kernel meal using a continuous SMB separation process. The process is useful for providing a simplified processing route to providing high purity d-mannose. The SMB process and the SMB cycle was operated to provide a high purity mannose stream comprising d-mannose, salts, and color agents, a primary raffinate comprising glucose, other sugars and salts, and a secondary raffinate consisting essentially of the mobile phase desorbent. In the SMB cycle, the secondary raffinate was recycled to the SMB process as the mobile phase desorbent without further desalination. The highly pure mannose stream was further treated to remove color agents and salts prior to subsequent steps of precipitation or crystallization and drying. D-mannose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant. | 02-06-2014 |
20140275518 | L-GLUCOSE PRODUCTION FROM L-GLUSOSE/L-MANNOSE MIXTURES USING SIMULATED MOVING BED SEPARATION - Disclosed is a process for the production of L-glucose from a mixture of L-mannose and L-glucose to provide a high purity L-glucose product. More particularly, the invention relates to a process for the isomerization of mixtures of L-mannose and L-glucose to favor the epimerization or transformation of the L-mannose into L-glucose combined with the selective removal of impurities and the selective separation of L-glucose by a multi-stage simulated moving bed SMB separation process integrating ion exclusion and isomer separation. The process is useful for providing a simplified and economic continuous processing route to providing pure L-glucose from mixtures of L-glucose and L-mannose in the presence of inorganic and organic salts and other sugars such as L-arabinose. L-glucose is useful as a sweetener, a laxative and as a therapeutic agent. | 09-18-2014 |
20140366869 | TAGATOSE PRODUCTION FROM DEPROTEINIZED WHEY AND PURIFICATION BY CONTINUOUS CHROMATOGRAPHY - Disclosed is a process for the production of d-tagatose from deproteinized whey or whey permeate containing lactose after acid hydrolysis to provide a hydrolysate comprising 1 equivalent of d-glucose and 1 equivalent of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose syrup as two products from lactose hydrolysate isomerate. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant. | 12-18-2014 |
20150129501 | FLASH CHROMATOGRAPHY COLUMN APPARATUS - A flash chromatography apparatus which provides an improved apparatus for large and medium commercial scale flash chromatography columns. More particularly, the invention relates to a flash chromatography column and cartridge system for positioning and ease of loading and unloading of stationary phase agent in the flash chromatography column. The flash chromatography column further provides flow distributors to support the stationary phase and permit plug flow through the column. The apparatus of the present is modular and can be disposed in any configuration to reduce maintenance cost and downtime in a commercial installation. Flash chromatography is widely used for purification of low molecular weight organic compounds and products of organic synthetic reactions. | 05-14-2015 |