Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Andrew Kenneth

Andrew Kenneth Hoffmann, Burnaby CA

Patent application numberDescriptionPublished
20080275343Percussion assisted angiogenesis - The present invention relates to a new non-invasive method for inducing angiogenesis and more particularly coronary angiogenesis wherein an operator applies localized percussion upon the upper torso proximate an ischemic myocardial region, whereby the percussive forces penetrate to cause sheer stresses to the endothelium of the coronaries which lie thereupon, and thereby cause new coronary growth by virtue of endogenous liberation of beneficial angiogenic mediators. A pair of vibratory contacts are advantageously applied to rib-spaces to either side of the sternum (or alternatively to the upper back), where-after percussion is applied at the resonance frequency of the heart/epimyocardium at a displacement amplitude of 0.1 mm-15 mm (preferably greater than 1 mm), such as to maximize an internal oscillatory effect. The system is also adaptable for cerebral and peripheral vasculature applications. Ultrasonic imaging may optionally be utilized to direct percussive therapy.11-06-2008
20080275371Vibrator with a plurality of contact nodes for treatment of myocardial ischemia - A vibrator for use in enhancement of pre-hospital coronary thrombolysis comprising a vibration source operable to generate vibration at a frequency in the range of 1-1000 Hz with at least a pair of oscillatory contacts spaced to enable simultaneous seating to the anatomic left and right of the sternum (such as to match the geometry of the right and left coronary arteries) of a patient in need of coronary thrombolysis. The preferred vibrator is operable to emit vibration in the low frequency sonic range (at least 20 Hz) with an amplitude of about 1 mm-15 mm (and more preferably greater than 2 mm), such as to provide an effective transthoracic tool for acute coronary thrombolysis applications. In a variation, greater than a pair of contacts are utilized to provide oscillatory contact at differing intercostal space levels (in order to maximize vibratory penetration to the heart which is variably situated depending on the patient's anatomy).11-06-2008
20090069728Randomic vibration for treatment of blood flow disorders - A therapeutic device and method for use thereof for treatment of blood flow disorders is disclosed. In one embodiment, a first line emergency response system for treatment of acute thrombotic and/or vasospastic vascular obstructions via the noninvasive application of low frequency vibration with at least one, and preferably a plurality of randomly administered vibratory waveform characteristics (herein after “Randomic Vibration”) is detailed. The disclosed apparatus and methods are based on the intuition that transcutaneously imparted low frequency randomic vibration can provide enhanced clot disruption and mixing of clot disruptive agents to acutely thrombosed vessels, due to the addition of mechanical chaos via non-regular, multi-vectored convection currents. In a preferred embodiment, the disclosed apparatus and methods preferably utilize randomic vibration as an adjunct to systemically administered drug therapy, most preferably intravenously administered thrombolytic drug therapy.03-12-2009
20090270773Automatically adjusting contact node for multiple rib space engagement - A vibratory attachment interface enabling transmission of oscillations generated by an oscillation source upon an external human body surface. The interface comprises a first contact node and a second contact node slideably mounted alongside the first contact node, wherein the contact nodes are each sized and shaped to enable seating within a human rib-space, and whereby upon forced engagement of the first contact node within a first rib-space, the second contact node automatically slides and conforms to the contour of a second differing rib-space thereby optimally nestling within the second rib-space. The attachment interface is for use in contoured application to preferably the anatomic left sternal border, third and fourth intercostal space, such as to enable and ensure an optimized vibratory transmission pathway from the chest wall to the base of the heart and coronary arteries thereupon.10-29-2009
20100222723Vibration method for clearing acute arterial thrombotic occlusions in the emergency treatment of heart attack and stroke - An emergency method of using localized mechanical percussion for enhancing clearance of potentially life threatening acute thrombotic arterial obstructions blocking blood flow to vital internal organs such as the heart or brain of a patient, comprising the step of applying non-invasive localized low frequency mechanical percussion at a frequency between 1 Hz-1000 Hz and a stroke or displacement amplitude in the range of 0.1-10 mm upon a targeted external body surface deemed generally proximate such acute thrombotic arterial obstruction, whereby said percussion accelerates the emergency clearance of the acute thrombotic arterial obstruction in restoration of blood flow to the vital internal organ. Preferred methods for percussion delivery to the chest wall/upper back or head/neck of a patient are described for use in treatment of heart attack or acute ischemic stroke respectively.09-02-2010

Patent applications by Andrew Kenneth Hoffmann, Burnaby CA

Andrew Kenneth Hoffmann, Surrey CA

Patent application numberDescriptionPublished
20080287793Low frequency vibration assisted blood perfusion emergency system - A non-invasive vibrator comprising a vibration source operable to generate vibration at a frequency in the range of 1-1000 Hz, and a phased array ultrasonic imaging transducer operatively connected to said vibration source, such as to enable targeting of vibration via an image generated on an ultrasonic display. The preferred vibrator is operable at a frequency greater than 20 Hz and an amplitude greater than 1 mm, such as to provide an effective, deeply penetrative transthoracic tool in remediation of blood flow disturbances within the thoracic cavity (such as acute myocardial infarction). In a variation, means for emitting a therapeutic low frequency ultrasonic waveform in concert with vibration in the range of 1-1000 Hz (wherein both waveforms are simultaneously directed by high frequency ultrasonic imaging) is also provided.11-20-2008

Patent applications by Andrew Kenneth Hoffmann, Surrey CA

Andrew Kenneth Takle, Essex GB

Patent application numberDescriptionPublished
20100087502Indazoles Used To Treat Estrogen Receptor Beta Mediated Disorders - The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.04-08-2010
20100311740IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS - This invention relates to newly identified imidazopyridine compounds of formula (I), to the use of such compounds in treating GERD and the like.12-09-2010
20100324106COMPOUNDS - The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.12-23-2010