Patent application number | Description | Published |
20080227988 | Crystallisation and Purification of Glycopyrronium Bromide - A method for the production of crystalline glycopyrronium bromide, comprises the reaction of glycopyrronium base with methyl bromide in a solvent, in which the solvent is selected such that the diastereoisomeric ratio of the product favours the R, S and S, R diastereoisomers over the R, R, and S, S diastereoisomers, and separating the desired diastereoisomers by one or more controlled crystallisation steps. This method gives a product having a particle size of narrow distribution. | 09-18-2008 |
20080234258 | Dihydroxyanthraquinones and Their Use - A compound of formula (1) | 09-25-2008 |
20080306162 | Treatment of Inflammatory Disorders and Pain - A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, is of formula (I) wherein R | 12-11-2008 |
20090012178 | Benzoxazocines and Their Therapeutic Use - A compound selected from (1S)-8-cyano-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine; (1R)-8-cyano-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine; (1S)-8-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine; (1S)-8-cyclopropyl-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine; (1S)-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-carboxamide; (1R)-5-methyl-1-(3-methoxy)phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine-8-carboxamide; and the salts thereof. These compounds have therapeutic utility. | 01-08-2009 |
20090062372 | Glycopyrronium Salts and Their Therapeutic Use - A glycopyrronium salt such as glycopyrronium iodide has a lower glass transition temperature than glycopyrronium bromide. It is therefore more suitable for formulation. | 03-05-2009 |
20090093509 | Methods and Compositions for the Treatment of Pruritus - The present invention is based on the discovery that a nalmefene salt or a peripherally acting analogue of nalmefene is capable of providing long-acting activity against pruritus, when applied topically. In addition, treatment with a nalmefene salt or peripherally acting analogue of nalmefene, can provide disease-modifying effects against the chronic symptoms of atopic dermatitis, including reductions of inflammatory cell infiltrate into the skin, epidermal hyperplasia and trans-epidermal water loss. Compositions of the invention have an inhibitory effect on the itch-scratch-cycle, leading to both relief of pruritus and disease-modifying activity. | 04-09-2009 |
20090270437 | Use of Buprenorphine or N-Alkylated Derivatives Thereof for Wound Healing - This invention relates to opioid compounds such as burenorphine or N-alkylated derivatives thereof for wound healing. | 10-29-2009 |
20090306216 | Use of Beta-Aminoalcohols in the Treatment of Inflammatory Disorders and Pain - A compound for therapeutic use, of the formula (I), wherein R | 12-10-2009 |
20090318562 | Use of Bupropion Metabolites for the Treatment of Inflammatory Disorders - Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (1) | 12-24-2009 |
20100016357 | Use of Beta-Aminoalcohols for the Treatment of Inflammatory Disorders and Pain - Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): wherein at least one of R1, R2 or R3 is not H and each is independently H, alkyl, CF | 01-21-2010 |