Andreotti
Amy H. Andreotti, Ames, IA US
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20080247953 | METHODS AND COMPOSITIONS FOR AFFECTING SUBSTRATE DOCKING OF KINASES IN MODULATING CELLULAR ACTIVITIES - The present invention relates to drug screening assays, therapeutic protocols and pharmaceutical compositions designed to target non-receptor tyrosine family kinases and components of the tyrosine kinase family signal transduction pathways. This includes primarily diseases or conditions associated with immune responses and can include treatment for cancers as well as various immune disorders. The invention reports a novel substrate SH2 domain docking mechanism apart from the kinase active site that is required for appropriate tyrosine phosphorylation by these tyrosine kinases. | 10-09-2008 |
20090010911 | METHODS AND COMPOSITIONS FOR AFFECTING CYCLOPHILIN A REGULATION OF KINASES IN MODULATING CELLULAR ACTIVITIES - The present invention relates to drug screening assays, therapeutic protocols and pharmaceutical compositions designed to target non-receptor tyrosine family kinases and components of the tyrosine kinase family signal transduction pathways. It has been previously reported by the inventors that a substrate SH2 domain docking mechanism apart from the kinase active site is required for appropriate tyrosine phosphorylation by these tyrosine kinases. According to the invention, it has been discovered that Cyclophilin A, the target of drugs such as cyclosporin A, mediates its regulatory effects by interacting with this remote SH2 domain, making modulation of this interaction possible for regulation and improved therapeutic intervention. | 01-08-2009 |
20140287434 | METHODS OF SCREENING FOR AND IDENTIFYING COMPOSITIONS WHICH MODULATE CELLULAR KINASE ACTIVITIES - The present invention relates to drug screening assays, therapeutic protocols and pharmaceutical compositions designed to target non-receptor tyrosine family kinases and components of the tyrosine kinase family signal transduction pathways. This includes primarily diseases or conditions associated with immune responses and can include treatment for cancers as well as various immune disorders. The invention reports a novel substrate SH2 domain docking mechanism apart from the kinase active site that is required for appropriate tyrosine phosphorylation by these tyrosine kinases. | 09-25-2014 |
Claudio Andreotti, Munich DE
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20090033364 | INTEGRATED CIRCUIT DEVICE FOR RECEIVING DIFFERENTIAL AND SINGLE-ENDED SIGNALS - An integrated circuit device includes a receiver that is capable of receiving and converting either differential input signals or two unrelated single-ended input signals. | 02-05-2009 |
Daniele Andreotti, Verona IT
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20080269208 | Pyridine Derivatives and Their Use in the Treatment of Psychotic Disorders - There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof: | 10-30-2008 |
20080306122 | Novel Compounds - Compounds of formula (I) wherein the variables are defined herein, pharmaceutical compositions thereof and methods for treatment using the same. | 12-11-2008 |
20090023757 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS - The present invention relates to a novel process for preparing compounds of formula (IA), which are potent and specific antagonists of corticotropin-releasing factor (CRF) receptors, from intermediate compounds of formula (I), by a coupling reaction catalysed by copper. | 01-22-2009 |
20090170902 | COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE - Compounds of formula (I), salts and solvates thereof are provided: | 07-02-2009 |
20100048656 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS - Compounds of formula (I) or a salt thereof are provided: | 02-25-2010 |
20100152175 | Pyridine Derivatives and Their Use in The Treatment of Psychotic Disorders - There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: | 06-17-2010 |
20110172255 | Condensed N-Heterocyclic Compounds and their Use as CRF Receptor Antagonists - The present invention provides compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF). | 07-14-2011 |
20130225584 | 2-(BENZYLOXY) BENZAMIDES AS LRRK2 KINASE INHIBITORS - The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by LRRK2 kinase activity, for example Parkinson's disease or Alzheimer's disease. | 08-29-2013 |
20150065504 | ANTIVIRAL COMPOUNDS - Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV). | 03-05-2015 |
20150238498 | COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS - Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV). | 08-27-2015 |
Daniele Andreotti, Cambridge GB
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20140038976 | PIPERAZINE DERIVATIVES AS CAV2.2 CALCIUM CHANNEL BLOCKERS - The invention relates to novel piperazine compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Ca | 02-06-2014 |
Daniele Andreotti, Brentford GB
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20120184553 | NOVEL COMPOUNDS - The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease. | 07-19-2012 |
Davide Andreotti, Soliera IT
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20120272619 | DEVICE AND METHOD FOR FEEDING A WEB OF A PACKAGING MATERIAL - A device for feeding a web of a packaging material along a path and towards an application station; wherein the packaging material comprises a plurality of pre-laminated holes at which application station applies respective opening devices. The device comprises an advancing mechanism for advancing the web along a first direction parallel to path; a sensor for generating a plurality of measure signals associated to the positions of pre-laminated holes; and a first motor controllable on the basis of measure signals. The first motor is operatively connected to the advancing mechanism for moving the advancing mechanism along a second direction transversal to path. | 11-01-2012 |
Leonardo Andreotti, Ferrara IT
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20110014433 | Multilayer paper material, method for its forming and method for obtaining three-dimensional containers - A multilayer papery material comprising at least one first sheet of three-dimensional structure and at least one second sheet fixedly coupled to the first sheet and defining empty spaces therein, wherein at least said second sheet is made of a papery material having a degree of extensibility of not less than 5% in all directions. | 01-20-2011 |
20120205429 | Container Composed of a Multilayer Paper Material and Method for Obtaining Such a Container - A multilayer papery material container includes at least one first sheet of a three-dimensional structure and at least one second sheet fixed to the first sheet and defining empty spaces therewith, wherein at least the second sheet is made of a papery material having a degree of extensibility of not less than 5% in all directions, and wherein the container includes a lateral wall provided with a relief motif. | 08-16-2012 |
Sara Andreotti, Gansbaai ZA
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20150321737 | Shark Barrier - A shark barrier includes a plurality of resiliently flexible, elongate members that extend in a generally upright condition between a sea floor and a sea surface. The elongate members are arranged so as to have the appearance of a thicket, preferably a kelp forest, when viewed from within the water and include magnets to assist in deterring certain shark species. The elongate members may be secured to the sea floor by an anchoring base and are held in the generally upright condition by a buoy or buoyant material held within the elongate members. | 11-12-2015 |
Simone Andreotti, Marnate IT
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20160047009 | SYSTEM FOR THERMAL TREATMENT OF RAILS - A system thermally treats rails. The system has a cooling device for spraying a cooling medium onto a rail to be treated. The cooling device defines a cooling path for receiving the rail to be treated. A conveyor moves the rail to be thermally treated through the cooling path. A vertically displacing device for displacing at least one of the cooling devices for adjusting a position of the one cooling device relative to the rail to be treated. | 02-18-2016 |
Stefano Andreotti, Modena IT
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20110120059 | PACKAGING METHOD AND UNIT FOR PRODUCING SEALED PACKAGES OF A FOOD PRODUCT POURABLE INTO A TUBE OF PACKAGING MATERIAL - A method of producing a sealed package of a pourable food product involving feeding a tube of packaging material along an axis; moving a pair of first jaws and a pair of second jaws cyclically and alternately along sealing paths parallel to the axis, and along repositioning paths; moving the jaws, as they travel along the sealing paths, into a closed position in which the sealing members grip the tube and respectively form, at different times, a first and a second seal sealing the tube and defining respective opposite ends of the package; and moving the jaws, as they travel along the respective repositioning paths, into an open position, in which they are detached from the tube; acquiring a desired value of a quantity related to the package weight; and forming the second seal at a distance, which is a function of the value, from the first seal. | 05-26-2011 |
20150135649 | PACKAGING UNIT AND METHOD FOR PRODUCING SEALED PACKAGES - A packaging unit for producing sealed packages from a tube of a sheet packaging material fed along a feed path having a first axis; unit comprises: jaws movable cyclically along path between a seal position in which they grip and seal tube to form sealing bands of packages, and a rest position in which they are detached from tube; and folding flaps fitted movably to jaws; folding flaps are movable between: an open position in which they are detached from tube, and a fully closed position in which they cooperate with tube for forming folded flaps in package; jaw means are also cyclically movable in an intermediate position, which is arranged between rest position and seal position; folding flaps are movable relative to jaws means into a partly closed position, which is arranged between open position and fully closed position, when jaw means are set in intermediate position. | 05-21-2015 |
Tracy Andreotti, Milford, MA US
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20130261641 | INSERTS FOR DIVIDING A MEDICAL DEVICE LUMEN - An insert or elongate member divides the lumen of an elongated medical device, such as the working channel of an endoscope, into two or more secondary lumens. The insert or elongate member thereby improves the ability of the lumen of the elongated medical device to accommodate multiple items or uses. The insert or elongate member is capable of securing one item, such as a pull line, such that it does not interfere with another item positioned in the lumen of the elongated medical device or with another use of the lumen of the elongated medical device. In accordance with some embodiments, a ligating instrument comprises a ligating band dispenser, a pull line, and an elongate member having a dividing wall structure or a plurality of lumens, wherein the elongate member divides a working channel of an endoscope into a plurality of secondary lumens. | 10-03-2013 |