Patent application number | Description | Published |
20080226922 | Cross-linkable polyionic coatings for medical devices - A method for making an article comprising a core material and a coating thereon, the method comprising the steps of: | 09-18-2008 |
20090117170 | SEGMENTED DEVICE FOR THE DELAYED RELEASE OF MOLECULES IN A TANGENTIAL DIRECTION THROUGH THIN FILMS AND USES THEREOF - The present invention of a segmented release device (sandwich construction with reservoir) for molecules (active compounds, medicaments, diagnostic, therapeutic and chemical reagents) is based on a construction which makes possible a constant release rate through diffusion-permeable intersegment films partially or completely filled with liquid of the neighboring media. The molecules pass here from the reservoir of the device into the outer medium by diffusion exclusively through the intersegment films. These intersegment films are adjustable in their thickness and composition in the manner specified in each case. | 05-07-2009 |
20090304756 | Method for the Encapsulation and Controlled Release of Poorly Water-Soluble (Hyprophobic) Liquid and Solid Active Ingredients - The invention relates to the filling of hydrophobic or hydrophobically modified porous microparticles with hydrophobic substances with subsequent encapsulation of the resulting hydrophobic particles using layer-by-layer (LbL) polyelectrolyte technology for the purpose of preparing homogeneous suspensions in water, and also for the controlled release of the encapsulated active ingredients. Through a specific modification of the LbL surface it is possible to realize preferred adhesion at the target site. | 12-10-2009 |
20100247599 | DRUG-RELEASING POLYELECTROLYTE COATING, METHOD FOR FORMING A DRUG-RELEASING POLYELECTROLYTE COATING, AND IMPLANTABLE DEVICE - A drug-releasing polyelectrolyte coating includes: (a) at least two oppositely charged polyelectrolyte layers; (b) at least one pharmaceutical active drug which is covalently coupled to polyelectrolytes of at least one of the polyelectrolyte layers; (c) wherein the drug exhibits a release rate from the polyelectrolyte coating of less than 50% in 3 days. | 09-30-2010 |
20120058151 | NANOPARTICULATE COMPOSITIONS OF POORLY SOLUBLE COMPOUNDS - The present invention relates to a method for the production of a nanoparticulate pharmaceutical composition. The method comprises the steps of a) suspending in water a poorly soluble active ingredient without the presence of a detergent, b) mechanically treating said suspension to obtain particles comprising the active ingredient with an effective average size of less than about 5000 nm, c) contacting said active ingredient or suspension with a first polyelectrolyte during and/or before mechanically treating, d) optionally contacting said suspension with a one or more second or further polyelectrolytes during, before and/or after mechanically treating, e) optionally drying said suspension. The invention also pertains to the pharmaceutical compositions obtained by the method of the invention. | 03-08-2012 |
20120196873 | STABILIZATION OF AMORPHOUS DRUGS USING SPONGE-LIKE CARRIER MATRICES - The present invention relates to drug formulations for the stabilization of amorphous forms of drugs. In particular the present invention relates to pharmaceutical compositions comprising sponge-like carrier matrices, particularly polyelectrolyte complexes or porous particles. The invention also relates to methods for the production of such pharmaceutical compositions. | 08-02-2012 |
20130136774 | POLYMERIC DRUG-DELIVERY MATERIAL, METHOD FOR MANUFACTURING THEREOF AND METHOD FOR DELIVERY OF A DRUG-DELIVERY COMPOSITION - A method for manufacturing a drug-delivery composition includes providing at least one pharmaceutically active compound, a dry powder comprising at least a polymer, and an aqueous solution. The dry powder, the pharmaceutically active compound and the aqueous solution are mixed to form a paste-like or semi-solid drug-delivery composition, wherein the aqueous solution is added in an amount of less than or equal to twice the total dry mass of the dry powder. | 05-30-2013 |
20130136775 | HYDROPHOBIC DRUG-DELIVERY MATERIAL, METHOD FOR MANUFACTURING THEREOF AND METHODS FOR DELIVERY OF A DRUG-DELIVERY COMPOSITION - A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition. | 05-30-2013 |
20140004170 | COATING OF A DRUG-ELUTING MEDICAL DEVICE | 01-02-2014 |
20140114241 | COATING OF SURFACES FOR SUSTAINED DRUG RELEASE - The present invention relates to a method for coating a surface of a substrate with a drug for sustained release: (i) providing a substrate with a surface to be coated, (ii) depositing at least one bilayer on at least a portion of said surface, wherein one layer of the bilayer comprises a polyelectrolyte and the other layer comprises a pharmaceutically active ingredient, and wherein the two layers of the bilayer are oppositely charged under conditions of the deposition and one layer of the bilayer has a substantially different net charge under physiological conditions. The invention also pertains to substrates with microscopic or macroscopic surfaces coated with the method according to the invention. | 04-24-2014 |
20140348923 | Polymeric Drug-Delivery Material, Method For Manufacturing Thereof And Method For Delivery Of A Drug-Delivery Composition - A method for manufacturing a drug-delivery composition includes providing at least one pharmaceutically active compound, a dry powder comprising at least a polymer, and an aqueous solution. The dry powder, the pharmaceutically active compound and the aqueous solution are mixed to form a paste-like or semi-solid drug-delivery composition, wherein the aqueous solution is added in an amount of less than or equal to twice the total dry mass of the dry powder. | 11-27-2014 |
20140356435 | Hydrophobic Drug-Delivery Material, Method For Manufacturing Thereof And Methods For Delivery Of A Drug-Delivery Composition - A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition. | 12-04-2014 |