| Patent application number | Description | Published |
|---|
| 20080237124 | Manufacture of Chromatography Matrices - The present invention relates to a method of manufacturing a chromatography matrix comprising providing a polysaccharide carrier comprising available hydroxyl groups; and reacting said hydroxyl groups with vinyl sulphonate to provide a sulphonate-functionalized (S-functionalized) cation exchanger. The hydroxyl groups of the carrier may be hydroxyls of the agarose polymer; or alternatively they may be provided on extenders such as polyhydroxyfunctional polymers. In one embodiment, the carrier is made of agarose with improved flow pressure properties. | 10-02-2008 |
| 20080249289 | Manufacture of a Chromatography Matrix - The present invention relates to method of manufacturing a sulphonate-functionalized (S-functionalized) cation exchanger, which method comprises reacting olefinic groups with bisulphite in the presence of at least one amine oxide, such as N-methyl morpholine oxide (NMO). The olefinic groups of the carrier may be allyl groups; which may be provided on extenders such as polyhydroxyfunctional polymers. In one embodiment, the carrier is made of agarose with improved flow pressure properties. | 10-09-2008 |
| 20080283792 | Separation Medium with Various Functionalities - The present invention relates to a separation medium with various functionalities suitable for, for example, isolation of proteins, cells, and viruses and also for diagnostic applications and cell cultivation. The separation medium comprises magnetic metal particles, preferably coated with an inert synthetic polymer, and pre-functionalised beads. These particles and beads are provided encapsulated in a hydrophilic porous polymer, preferably agarose. The beads may be used for cell cultivation or for chromatography. When the beads are used for chromatography the agarose layer may be provided with ligands having affinity for selected biomolecules. | 11-20-2008 |
| 20090092837 | MAGNETIC BEADS - The present invention relates to magnetic beads in the form of composite beads with an inner core of metal particles, which are coated with an inert synthetic polymer and thereafter a hydrophilic porous polymer, preferably dextran. This provides porous biocompatible beads without metal leakage. This construction also allows for simple and convenient handling of cell expansion media by magnetism. | 04-09-2009 |
| 20090138208 | IMMUNOGLOBULIN G BINDING POCKET - The present invention relates to a human IgG binding pocket comprised of a first interacting surface, which originates from an IgG κ light chain, and a second interacting surface, which originates from an IgG heavy chain, which amino acids are strictly conserved between human IgGs of κ-type. The invention also embraces an isolated and purified polypeptide, which comprises said binding pocket. Further, the invention relates to various methods of using the novel binding pocket, such as in screening for identification of chemical entities capable of selective binding thereof, and in other experimental and/or virtual methods for design and/or identification of chemical entities capable of selective binding thereof. | 05-28-2009 |
| 20090200239 | METHOD FOR GENERATING METAL CHELATING AFFINITY LIGANDS - The present invention relates to a method for generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of | 08-13-2009 |
| 20090259029 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELECTIVE ADSORPTION OF IGG - The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula | 10-15-2009 |
| 20100035273 | METHOD AND DEVICE FOR SMALL SCALE REACTIONS - The present invention relates to a method and a device for small scale reactions, such as sample preparation of a desired substance in a sample. In the method using the device samples mixed with functionalized magnetic particles are magnetically transferred between different working stations on the device. The method uses a hydrophobic surface, such as a Petri dish, provided with hydrophilic spots of, for example, agarose beads located on said hydrophobic surface and provided with buffers, reactants or ligands. | 02-11-2010 |
| 20100059440 | CROSS-LINKED CELLULOSE MEMBRANES - The invention relates to a process for making porous cross-linked charged cellulosic polymeric membranes capable of binding to a target molecule. The invention provides methods for separating target molecules from other components in a solution comprising use of membranes obtainable by the process of the invention. The method has particular utility in separating proteins and nucleic acids from cell lysates and cultures. | 03-11-2010 |
| 20100081121 | MEDIA AND METHOD FOR CELL SEPARATION - The present invention relates to a separation media and a method for separation of cells from different cell sources, such as umbilical cord blood, using the separation media to obtain the desired cells, such as stem cells. The separation media has beads with a diameter of 200-500 μm and is provided with cell separation ligands. The cell specific ligands are preferably CD3 and CD19 for depletion of B and T cells and production of a stem cell rich product. | 04-01-2010 |
| 20100320149 | SEPARATION MATRIX - The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used. | 12-23-2010 |
