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Anderson, MA
Ana C. Anderson, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100061992 | THERAPEUTIC USES OF TIM-3 MODULATORS - The invention provides novel methods of treating neurological disorders, including neurodegenerative disorders such as MS. The invention also provides novel methods of treating cancers, including glial tumors such as glioblastoma multiforme. The invention further provides vaccines and related uses. | 03-11-2010 |
Ana Carrizosa Anderson, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110059106 | METHODS FOR MODULATING A POPULATION OF MYELOID-DERIVED SUPPRESSOR CELLS AND USES THEREOF - The invention provides for methods of modulating a population of myeloid-derived suppressor cells (MDSCs) in a subject, for treating an autoimmune disease, and also treating cancer in a subject in need thereof. The methods comprise administering to the subject a therapeutically effective amount of an agent that modulates the Tim-3 pathway. The Tim-3 pathway can be activated by a Tim-3 ligand, galectin-9, whereby MDSCs are expanded, or inhibited by an antibody to Tim-3, wherein the expansion of MDSCs is inhibited. | 03-10-2011 |
Anne H. Anderson, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090265753 | USING OPAQUE GROUPS IN A FEDERATED IDENTITY MANAGEMENT ENVIRONMENT - A system and method for using an opaque group within a federated identity management environment, to prevent disclosure of identities of the group. An opaque group is constructed at an identity provider within the system and has a group identity that references primary system identities of its members (e.g., electronic mail addresses, public key certificates, network addresses). Services to the group (e.g., distribution of an object such as a document or electronic mail message, invitation to an online meeting, authentication as a member of the group) can be requested from service providers, but because service providers do not have access to members' primary identities, the service providers forward the requests to an identity provider that has access to the group identity. That identity provider retrieves the members' identities and completes the action. | 10-22-2009 |
| 20100042973 | METHOD FOR ANALYZING AN XACML POLICY - XACML (eXtensible Access Control Markup Language) documents, PolicySets and Policies can become long, complex and difficult to completely comprehend. A method is provided for facilitating analysis of such code to make it easier to answer questions such as: Given a particular set of Attribute values (and/or others unknown as of now), what is permitted or denied; are any of the rules redundant; are any of the rules inconsistent; for any pair of policies in the code, what set of Attributes will they both return Permit; how can a policy be refactored into an equivalent set of policies in which each branch of the policy tree pertains to specific values of specified Attributes? To facilitate such analysis and refactoring, every Rule in the collection of policies being analyzed is reduced to an equivalent expression in DNF (Disjunctive Normal Form). Some terms, predicates and other elements may be eliminated. | 02-18-2010 |
Bradley Paul Anderson, Fort Lauderdale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080263629 | METHODS AND SYSTEMS FOR COMPLETING, BY A SINGLE-SIGN ON COMPONENT, AN AUTHENTICATION PROCESS IN A FEDERATED ENVIRONMENT TO A RESOURCE NOT SUPPORTING FEDERATION - A system for distributed authentication includes a client machine, in a first domain in a federation, that receives from a user a first set of authentication credentials. The system also includes an intermediate machine in a second domain in the federation, a server, also in the second domain, a password management program executing on the server and a non-federated resource. The intermediate machine authenticates the user responsive to receiving the first set of authentication credentials and identifies a second set of authentication credentials. The server in the second domain authenticates the user, responsive to the second set of authentication credentials. The password management program, executing on the server, retrieves a third set of authentication credentials associated with the user. The non-federated resource authenticates the user, responsive to receiving, from the password management program, the third set of authentication credentials. | 10-23-2008 |
Bryan E. Anderson, Milford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110119205 | SYSTEMS AND METHODS FOR DETERMINING AN EARNINGS PORTION OF A DISTRIBUTION FROM A 529 PLAN - A method for determining an earnings portion of a distribution from a 529 plan. The method includes receiving information associated with a plurality of 529 plan accounts, identifying related 529 plan accounts, aggregating the information for related 529 plan accounts, and determining an earnings portion of a distribution from at least one of the 529 plan accounts. | 05-19-2011 |
Daniel Anderson, Sudbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110183867 | Polymer arrays for biofilm adhesion testing - This invention relates to a method of screening arrays of polymers having pre-determined surface energies. The polymer arrays of the present invention can be used to screen for microorganism adherence. More specifically the arrays can be used to screen for adherence of particular bacteria or fungi to particular polymers in the array. Furthermore, this invention relates to a method combining in-situ polymer synthesis with physico-chemical characterisation of the resulting polymer array and subsequent biological assays of bacterial or fungal adherence. This allows for high throughput screening and characterisation of candidate polymers which are not susceptible to bacterial or fungal adherence or which can be used to support bacterial or fungal adherence where such is required. The arrays can also be used to screen for inhibition or promotion of biofilm formation. | 07-28-2011 |
Daniel G. Anderson, Sudbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080242626 | End-Modified Poly(beta-amino esters) and Uses Thereof - Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers. | 10-02-2008 |
| 20100196492 | ELECTROSTATIC COATING OF PARTICLES FOR DRUG DELIVERY - A system for electrostatically coating particles is provided. The system is particularly well suited for coating charged drug delivery particles (e.g., nanoparticles, microparticles) with a coating of opposite charge. The coating may include a targeting moiety such as a small molecule ligand, peptide, protein, aptamer, etc. The coated particles are biodegradable and/or biocompatible, have a near neutral zeta (ξ) potential, and are stable in serum. The invention also provides pharmaceutical compositions and kits including the inventive coated particles. Methods of preparing and using the inventive particles are also included. | 08-05-2010 |
| 20100234244 | USES AND METHODS OF MAKING MICROARRAYS OF POLYMERIC BIOMATERIALS - A microarray of polymeric biomaterials is provided. Specifically, a microarray of polymeric biomaterials that comprises a base with a cytophobic surface, and a plurality of discrete polymeric biomaterial elements bound to the cytophobic surface, is provided. Preferably said polymeric biomaterials comprise a synthetic polymer. Said polymeric biomaterials may also comprise other compounds covalently or non-covalently attached to said synthetic polymer. Methods of preparing the microarray of polymeric biomaterials of the present invention and uses of the microarray of polymeric biomaterials of the present invention are also provided. | 09-16-2010 |
| 20100273259 | SUBSTRATES AND METHODS FOR CULTURING STEM CELLS - The present disclosure provides a device and a cell culture system comprising a substrate that generates significant chemical ion signatures adapted for culturing stem cells. This disclosure further provides unique surface properties, such as surface wettability, along with defined polymer microspot environments in an array, for effectively supporting the propagation and differentiation of human pluripotent stem cells in vitro. Methods of culturing, maintenance, differentiating stem cells as well as reprogramming somatic cells into stem cells using the device and the cell culture system with the suitable substrates, along with suitable culture media, are also provided. | 10-28-2010 |
| 20100331234 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF - Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. | 12-30-2010 |
| 20110163469 | HIGH-THROUGHPUT FABRICATION OF MICROPARTICLES - The high-throughput fabrication of microparticles based on the double emulsion/solvent evaporation technique for screening and optimizing microparticle formulations for particular characteristics allows for the preparation of multiple microparticle formulations in parallel. The system involves the formation of an emulsion containing aqueous bubbles with the payload in an organic phase containing the polymer or polymer blend being used for the microparticles. This first emulsion is then transferred to a larger aqueous phase, and a second waterin-oil-in water emulsion is formed. The organic solvent is then removed, and the resulting particles are optionally washed and/or freeze dried. The resulting microparticles are similar or better than microparticles prepared using the traditional one formulation at a time approach. The high-throughput fabrication of microparticles is particularly useful in optimizing microparticles formulations for drug delivery. | 07-07-2011 |
| 20120065358 | BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF - Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. | 03-15-2012 |
Daniel G. Anderson, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100036084 | BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF - Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. | 02-11-2010 |
| 20110009641 | Amine-containing lipids and uses thereof - Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. | 01-13-2011 |
David E. Anderson, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100061992 | THERAPEUTIC USES OF TIM-3 MODULATORS - The invention provides novel methods of treating neurological disorders, including neurodegenerative disorders such as MS. The invention also provides novel methods of treating cancers, including glial tumors such as glioblastoma multiforme. The invention further provides vaccines and related uses. | 03-11-2010 |
| 20110245107 | SELECTIVE DIFFERENTIATION, IDENTIFICATION, AMD MODULATION OF HUMAN TH17 CELLS - The embodiments provide for the modulation of both the differentiation and activity of human TH17 cells. More specifically, human TH17 cell differentiation can modulated by TGF-? and IL-21, and their agonists and antagonists. Function of TH17 cells can be modulated by, for example, BLT1 or podoplanin, and their agonists and antagonists. Additionally, the embodiments provide for the identification of TH17 cells. More specifically, human TH17 cells specifically upregulate BLT1 and podoplanin. | 10-06-2011 |
David E. Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110097418 | COMPOSITIONS AND METHODS FOR TREATING INFLUENZA - The present application provides compositions and methods useful for treating influenza. As described herein, the compositions and methods are based on the development of peptides and peptide combinations which exhibit immunogenic properties against influenza. In some embodiments, the peptide combinations induce a protective response against multiple strains of influenza, e.g., seasonal strains of influenza or even the new pandemic influenza A (H1N1) virus of swine origin. | 04-28-2011 |
| 20110177163 | COMPOSITIONS AND METHODS FOR TREATING HEPATITIS A - The present application provides compositions and methods useful for treating hepatitis A. In particular, while hepatitis A vaccines are currently limited to parenteral administration routes (i.e., intramuscular injection), we have identified compositions that induce a protective response when administered orally. | 07-21-2011 |
David Evander Anderson, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090117141 | HIV VACCINE COMPOSITION - An anti-HIV vaccine composition is disclosed. The vaccine comprises an combination of immunogenic peptide mixtures, which mixtures may be prepared in a single synthesis. The composition collectively represents the in vivo variability seen in immunogenic epitopes from highly variable regions of HIV. Immunization with the vaccine elicits broadly reactive immunity (CTL and T helper cell responses) against the divergent strains of HIV upon which it is based. The vaccine may be formulated to target regionally distinct variability based on an HIV clade predominant in a geographical region. | 05-07-2009 |
David K. Anderson, East Longmeadow, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120031429 | Device and Method for Cleaning Selective Catalytic Reduction Protective Devices - One embodiment described herein relates to a system for removing pollutants from a flue gas. The system includes a selective catalytic reduction (SCR) system having a SCR reactor containing a NO | 02-09-2012 |
David P. Anderson, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110024582 | GROUND MOUNTED SOLAR MODULE INTEGRATION SYSTEM - Embodiments of the present inventions are directed to systems, devices for use with systems, and method of mounting and retaining solar panels. A solar module mounting system may include: a support mechanism including a support post pivotably attached to a support base, and an attachment module for attaching a solar panel to the support mechanism. | 02-03-2011 |
D. Ryan Anderson, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110319352 | Compounds That Bind Oxysterol Binding Proteins, and Methods of Use Thereof - The invention relates in part to the discovery that certain CRAMs, such as schweinfurthin A, target OSBPs (a family of oxysterol binding proteins). Because OSBPs have been shown to be integral to atherosclerosis and Alzheimer's disease (AD), one aspect of the invention relates to the use of CRAMs, or a pharmaceutically acceptable salt, biologically active metabolite, solvate, hydrate, prodrug, enantiomer or stereoisomer thereof, in the treatment and/or prevention of atherosclerosis, Alzheimer's disease and related disorders. Another aspect of the invention relates to novel derivatives of CRAMs, or a pharmaceutically acceptable salt, biologically active metabolite, solvate, hydrate, prodrug, enantiomer or stereoisomer thereof, for the treatment and/or prevention of atherosclerosis, Alzheimer's disease and related disorders. Another aspect of the invention relates to the use of an immobilized CRAMs, such as OSW-I, to aid in screening of compounds to identify additional OSBP binders. Other aspects of the invention relate to the use of CRAMs to treat cancer, such as p21-deficient cancers. | 12-29-2011 |
Dustin L. Anderson, Brighton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100075325 | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER - The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. | 03-25-2010 |
Gary Anderson, Leominster, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100294122 | PROTECTION SYSTEM INCLUDING A NET - A net deployment system which, in one example, includes a manifold assembly including multiple weight ducts and a bladder port. A weight is disposed in each weight duct and each weight is tied to the net. A bladder is behind the net and is over the bladder port. At least one inflator charge is associated with the manifold for inflating the bladder and firing the weights out of the weight ducts to deploy the net in the path of an incoming threat. | 11-25-2010 |
| 20100307328 | Protection system - A net deployment system which, in one example, includes a manifold assembly including multiple weight ducts and a bladder port. A weight is disposed in each weight duct and each weight is tied to the net. A bladder is behind the net and is over the bladder port. At least one inflator charge is associated with the manifold for inflating the bladder and firing the weights out of the weight ducts to deploy the net in the path of an incoming threat. | 12-09-2010 |
| 20120011994 | Protection system - A net deployment system which, in one example, includes a manifold assembly including multiple weight ducts and a bladder port. A weight is disposed in each weight duct and each weight is tied to the net. A bladder is behind the net and is over the bladder port. At least one inflator charge is associated with the manifold for inflating the bladder and firing the weights out of the weight ducts to deploy the net in the path of an incoming threat. | 01-19-2012 |
James E. Anderson, Hudson, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080219927 | ADENOSINE DERIVATIVE FORMULATIONS FOR MEDICAL IMAGING - A stable composition useful for myocardial perfusion imaging contains one or more 2-alkynyladenosine derivatives; and a solvent which is made up of water and hydroxypropyl-β-cyclodextrin. | 09-11-2008 |
James Eric Anderson, Hudson, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090263347 | ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS - Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues. | 10-22-2009 |
| 20100331266 | ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS - Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. | 12-30-2010 |
James J. Anderson, Natick, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090166428 | METHODS AND APPARATUS FOR USE IN ASSOCIATION WITH MEDIA - According to some embodiments, a method comprises providing a media including a plurality of coupled pages, the plurality of coupled pages including at least one printed page defined by at least one printed sheet; coupling at least one RF identification token to the at least one printed sheet; and storing information in the at least one RF identification token, the information including information regarding a plurality of products. According to some embodiments, apparatus comprises a media including a plurality of coupled pages, the plurality of coupled pages including at least one printed page defined by at least one printed sheet; and at least one RF identification token coupled to the at least one printed sheet, the at least one RF identification token including stored information regarding a plurality of products. | 07-02-2009 |
James William Anderson, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080263185 | AUTOMATIC CONFIGURATION OF THE NETWORK DEVICES VIA CONNECTION TO SPECIFIC SWITCH PORTS - A method and system for automatically configuring devices in a network is disclosed. A network management software application is provided that enables a user to associate policy settings with physical locations in the network. During an operational mode of the network management application, the application automatically detects when a network device is plugged into the network, and determines a location of the device in the network. The device is then automatically configured based on the policy settings associated with the corresponding location. | 10-23-2008 |
Jeffrey T. Anderson, West Yarmouth, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090280970 | METHOD AND APPARATUS FOR INCREASING EFFECTIVENESS OF ABDOMINAL EXERCISES - Apparatus in the form of a wedge made of foam having a density capable of maintaining a user's spine extended during use is employed during abdominal exercise to prevent posterior pelvic tilt (PPT) during the exercise and thereby promote elastic remodeling of the spinal ligament. | 11-12-2009 |
Jessica K. Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120089122 | TIME-SELECTIVE BIORESORBABLE OR COLLAPSIBLE DRUG DELIVERY SYSTEMS AND METHODS - Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder. | 04-12-2012 |
Karen Anderson, Falmouth, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080235064 | METHOD AND APPARATUS FOR PERFORMING ASSESSMENTS - Described are techniques used in connection with providing insolvency services in connection with guaranty funds, such as property and casualty guaranty funds, upon the occurrence of an insurance company insolvency. A client/server system provides for creating and maintaining a database of state and insurance company member information. Operations, such as calculations, are performed in accordance with different rules that are associated with varying state laws and rules that may vary with insurance account. A range of functions are performed by the system comprising report generation, unearned premium calculations, assessment calculation, claim entry and management, administrative tasks, and other related operations. The system which provides services and operations in connection with managing insolvency funds may interact with other applications and systems, such as an accounting system, word processing system, and the like by generating data used as input in these other systems. Also described is a database schema representing a relationship between the different data entities that may be stored in a database in connection with performing insolvency operations. | 09-25-2008 |
Karin Anderson, Georgetown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090017460 | DIFFERENTIAL EXPRESSION PROFILING ANALYSIS OF CELL CULTURE PHENOTYPES AND USES THEREOF - The present invention provides, among other things, systems and methods for identifying genes and proteins that regulate and/or are indicative of cell phenotypes based on expression profiling analysis. The present invention further provides methods of manipulating identified genes and proteins to engineer improved cell lines. | 01-15-2009 |
| 20090325175 | METHODs OF DETECTION AND QUANTIFICATION OF HOST CELL DNA CONTAMINATION OF PURIFIED PROTEINS - The present invention provides a novel robust, sensitive, reproducible, and accurate method of detecting and quantifying host cell genomic DNA contamination utilizing quantitative real time Polymerase Chain Reaction (qPCR), wherein the qPCR primers are complementary to the highly repetitive host cell genomic DNA sequences, e.g., Alu-equivalent sequences. The present invention is particularly useful for determining the levels of residual genomic DNA in biological products to be administered as therapeutics, e.g., therapeutic proteins. | 12-31-2009 |
Kenneth Anderson, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090156469 | METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF IN TREATING WALDENSTROM'S MACROGLOBULINEMIA - Disclosed are methods of treating Waldenstrom's Macroglobulinemia comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula I. | 06-18-2009 |
| 20090169570 | METHODS AND AGENTS FOR IMPROVING TARGETING OF CD138 EXPRESSING TUMOR CELLS - Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents. | 07-02-2009 |
Kenneth C. Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100172893 | Use of Reversine and Analogs For Treatment of Cancer - Herein is provided methods and compositions for treating cancer. In one embodiment, a method is provided for treating a patient suffering from cancer, the method comprising administering to the patient an effective amount of reversine, reversine analog or reversine containing agent. In another embodiment, compositions comprising reversine are provided. Such compositions may further comprise additional active agents and other additives. The compositions and methods provided herein are useful, for example, in the area of medicine. | 07-08-2010 |
Kenneth C. Anderson, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090036390 | COMPOSITIONS AND METHODS FOR TREATING NEOPLASTIC DISEASES - Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma. | 02-05-2009 |
| 20090170862 | USE OF C-KIT INHIBITORS FOR THE TREATMENT OF MYELOMA - The present invention relates to the use of a c-kit inhibitor, especially a c-kit inhibitor of formula I, | 07-02-2009 |
| 20090286770 | Use of Staurosporine Derivatives for the Treatment of Multiple Myeloma - The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving ras or FGFR3 signalling pathways and l or c-fos transcription, especially for the curative and/or prophylactic treatment of myeloma or multiple Myeloma, and to a method of treating diseases involving ras or FGFR3 signalling pathways and/or c-fos transcription. | 11-19-2009 |
| 20090286823 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders - The invention relates to the use of inhibitors of CCR1 for the treatment of cancers and osteolytic bone disorders. In some embodiments, the invention relates to methods for the treatment of multiple myeloma, smoldering multiple myeloma and secondary bone cancers. | 11-19-2009 |
| 20100286090 | Treatment of Multiple Myeloma - Methods for treating multiple myeloma comprising administering a therapeutically effective amount of dasatinib to a patient in need of treatment thereof. Dasatinib can be administered alone or in combination with a second anti-neoplastic agent such as dexamethasone or bortezomib. The patient may be refractory to prior treatment with an anti-neoplastic agent other than dasatinib. | 11-11-2010 |
Kenneth C. Anderson, Weston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110159021 | XBP1, CD138, AND CS1 PEPTIDES - The disclosure features, inter alia, immunogenic XBP1-, CD138-, and CS1-derived peptides (and pharmaceutical compositions thereof). The peptides can be used in a variety of methods such as methods for inducing an immune response, methods for producing an antibody, and methods for treating a cancer (e.g., a plasma cell disorder such as multiple myeloma or Waldenstrom's macroglobulinemia). The peptides can also be included in MHC molecule multimer compositions and used in, e.g., methods for detecting a T cell in a population of cells. | 06-30-2011 |
Kent D. Anderson, East Longmeadow, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090100560 | LAUNDERABLE TRITIUM HOOD - Applicant has disclosed a “Launderable Tritium Hood” with a removable visor assembly that allows the visor (i.e., view plate) and the remainder of the hood to be cleaned separately, and by different methods, for their reuse. In the preferred embodiment, Applicant's invention comprises: a launderable tritium suit hood; a removable visor assembly with a visor removably attached to a channel assembly; and, a bead assembly attached to the hood's fabric by stitching, wherein the channel assembly, with its attached visor, can be press-fit onto the bead assembly and subsequently peeled off when desired. Applicant's invention can also be thought of as a method comprising: press fitting a removable visor assembly onto a bead affixed to a tritium suit hood to create a gas-tight seal between the visor assembly and hood; and lifting and peeling the visor assembly off the bead to remove the visor assembly from the hood. | 04-23-2009 |
Kevin W. Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090287016 | Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions - One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems. | 11-19-2009 |
Laplie Anderson, East Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100232591 | Electronic telephone directory system - An electronic telephone directory system is described. Each entry in the directory has summary information, category specific information, and associated categories. The system displays a different view of the category specific information depending on categories associated with an entry. For example, a restaurant may have a detailed view that shows its menu and specials whereas the detailed view for a taxi service shows the company's coverage area. The directory periodically updates using cellular networks but generally operates without an active network connection. | 09-16-2010 |
Marc Anderson, Lunenberg, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120130347 | Pump With Integrated Control Unit - A pump for use in anal irrigation includes a control unit integrated in the pump. The control unit includes a cylindrical housing element and a valve element fitted in the housing. The valve element and the housing element are adapted for rotating with respect to each other between a position allowing the pump to pump air into a balloon, a position allowing the pump to pump air into a reservoir bag and an evacuation position. The control unit is actuated by a handle attached to the rotatable valve element. The handle extends radially out from the rotatable valve element and the cylindrical housing. | 05-24-2012 |
Marko Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100274852 | Method and Apparatus for Sharing Context to One or More Users - In accordance with an example embodiment of the present invention, an apparatus comprises at least one processor and at least one memory. The at least one memory includes computer program code. Further, the at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus to perform at least the following receive content related to a first contact based at least in part on a configuration of a second contact. Further, the apparatus comprises a user interface configured to display the content. | 10-28-2010 |
| 20110276632 | PREDICTIVE DATA OBJECTS - Profile information for a user is generated and based on the profile information predictive data objects associated with a particular user are generated. Predictive data objects for the user are transmitted and at least one data object from the generated predictive data objects is selected. An option for the user to discover an additional data object from an internal or external network related to the selected data object is provided and information on the discovered data object is stored. An option for the user to share the selected data object to other users within the internal or external network is provided and information on the selected data object is stored. The profile information comprises at least one of the following dynamic filters: personal filter, social filter or contextual filter. | 11-10-2011 |
Meredith L. Anderson, Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090254151 | LEAD ANCHOR FOR IMPLANTABLE DEVICES AND METHODS OF MANUFACTURE AND USE - A lead anchor includes a body with opposing first and second major surfaces and at least one edge surface between the first and second major surfaces. The body defines a first channel, a second channel, and a notch. The first channel extends from the edge surface of the body and is open at the first major surface. The second channel extends from the edge surface of the body and is open at the second major surface. The notch extends from the edge surface of the body, defines an opening from the first major surface through the body to the second major surface, and intersects the first channel and the second channel. The first channel, the second channel, and a portion of the notch define a passage through the body so that a lead can be inserted into the notch and turned to dispose a portion of the lead within the passage. The lead anchor can be part of a kit or system that also includes a lead. | 10-08-2009 |
| 20100152818 | NON-LINEAR ELECTRODE ARRAY - A system for stimulation includes an implantable pulse generator, a lead, and conductors. The lead includes an array body disposed at a distal end of the lead and electrodes concentrically arranged on the array body. A center electrode may also be disposed on the array body. The electrodes may be arranged in more than one concentric ring. A method of using an implantable stimulator includes implanting an implantable stimulator and providing an electrical signal to at least one electrode of the implantable stimulator to stimulate a tissue. The electrical signal may be provided between diametrically opposed electrodes or between electrodes that are not diametrically opposed. If the implantable stimulator has a center electrode, the electrical signal may be provided between the center electrode and at least one concentrically arranged electrode. | 06-17-2010 |
Mike Anderson, Lowell, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110079135 | Vehicle and structure shield net/frame arrangement - A vehicle and structure shield system including a flexible structure with a fabric border including one of a hook and loop type fastener thereon, a frame for the flexible structure including frame members with the other of hook and loop fastener thereon for releasably securing the flexible structure to the frame, and hard points attached to the flexible structure. | 04-07-2011 |
| 20110203453 | Vehicle and structure shield hard point - A vehicle and structure shield hard point includes a forward facing base portion defined by a front face, sidewalls extending rearward from the front face including slots therethrough for the cords of a net, and a cavity surrounded by the sidewalls. A plug is sized to be frictionally received in the cavity of the forward facing base portion locking the cords of the net with respect to the forward facing base portion. | 08-25-2011 |
Paul Anderson, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110046209 | RNA-Induced Translational Silencing and Cellular Apoptosis - The invention is directed to RNA molecules that can be used to inhibit protein synthesis and to induce cells to undergo apoptosis. It also includes pharmaceutical compositions containing the RNAs that can be used in treating or preventing tumors; abnormal dermatological growths and viral infections. | 02-24-2011 |
Peter T. Anderson, Andover, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080287783 | SYSTEM AND METHOD OF TRACKING DELIVERY OF AN IMAGING PROBE - A system and method to track delivery of a surgical instrument through an imaged subject is provided. The system comprises a controller and an imaging system including an imaging probe in communication with the controller. The imaging probe includes a transducer array operable to acquire image data through a range of motion about a longitudinal axis and in a direction of image acquisition with the imaging probe stationary. The system also includes a tracking system to track a position of the imaging probe relative to a second object tracked by the tracking system, and a display illustrative of a direction of image acquisition of the imaging probe relative to an illustration of a position of the second object. | 11-20-2008 |
Randall Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100205206 | SYSTEM AND METHOD FOR DISPLAYING DATA ON A THIN CLIENT - A thin-client user interface includes a user interface and an application server. The user interface is executed on a client device, such as a personal computer having a display. The user interface includes a client application for displaying data. The application server is coupled with the user interface and with a remote database via an electronic data network and is configured to receive a request for data from the user interface, to generate a query request based on the request for data, to access the database and submit the query request to the database, to receive results from the database in response to the query request, and transmit a portion of the results to the user interface. | 08-12-2010 |
Richard R. Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100053607 | FLUORESCENCE POLARIZATIO IMAGING DEVICE AND METHOD - The present invention is directed to a novel multi-spectral exogenous fluorescence polarization imaging technique that enables rapid imaging of large tissue fields. The imaging device includes a tunable monochromatic light source and a CCD camera. Linear polarizers are placed into both the incident and collected light pathways in order to obtain fluorescence polarization or/and anisotropy image. To acquire exogenous fluorescence image, fluorescent contrast agents are delivered to a target tissue. | 03-04-2010 |
| 20100305495 | METHOD AND APPARATUS FOR DERMAL DELIVERY OF A SUBSTANCE - The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance. | 12-02-2010 |
| 20110264115 | METHOD AND APPARATUS FOR GRAFTING OF SKIN TISSUE - Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site. | 10-27-2011 |
| 20110313411 | METHOD AND APPARATUS FOR DERMATOLOGICAL HYPOPIGMENTATION - Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation. | 12-22-2011 |
| 20120029348 | METHOD AND APPARATUS FOR MULTIMODAL IMAGING OF BIOLOGICAL TISSUE - The present invention is directed to a novel multi-wavelength imaging method and apparatus that enables rapid imaging of tissue regions with accurate identification of tissue types within the region. Optical properties, such as co-polarized or cross-polarized fluorescence or reflectance intensity, optical density and/or reflectance, can be determined at a plurality of locations within the tissue region for each wavelength. Said properties at the two wavelengths, including calculated derivatives of the optical property with respect to wavelength, can be analyzed to image tissue structures and identify tissue types within the tissue region more accurately than can be achieved based on properties measured at a single wavelength. | 02-02-2012 |
| 20120041430 | METHOD AND APPARATUS FOR TISSUE GRAFTING - Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. The exemplary apparatus can be provided that includes a plurality of such tubes for simultaneous harvesting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, or less than about 0.3 mm, which can promote healing of the donor site and/or viability of the harvested tissue. The micrografts can be approximately cylindrical or strip-shaped, and can be placed in a biocompatible matrix to form a graft or directly into tissue at the recipient site. Such exemplary micrografts can be obtained from skin or other types of tissue, e.g., various internal organs. | 02-16-2012 |
| 20120071764 | DEVICE AND METHOD FOR WIDE-FIELD AND HIGH RESOLUTION IMAGING OF TISSUE - A device for wide-field and high resolution imaging of an object surface includes first and second imaging modalities, a lens associated with the second imaging modality. The first imaging modality is high resolution with a first observation line. The second imaging modality is arranged in an image plane at a first angle with respect to an object plane and has a second observation line and a wider imaging field than the first imaging modality. The lens associated with the second imaging modality is arranged in a lens plane at a second angle with respect to the object plane, where the second angle being equal to about one-half of the first angle. The first and second imaging modalities are mutually arranged such that the first and second optical axes intersect at a point on the object plane. | 03-22-2012 |
Richard Rox Anderson, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110237860 | Magnetic Ink Tissue Markings - The invention provides tissue markings (such as tattoos) comprising magnetic particles, e.g., magnetite, and methods for making and altering, e.g., removing them. | 09-29-2011 |
Richard Rox Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080269608 | Non-Invasive Treatment of Fascia - Various methods and devices for minimally invasive treatment and prevention of conditions of the fascia are provided. In one aspect, a method includes providing an acoustic wave source effective to deliver a focused acoustic wave to a target site within a patient's body, and focusing an acoustic wave through a patient's skin such that at least one location in the patient's fascia is fenestrated in a desired pattern. | 10-30-2008 |
| 20090088733 | Methods and apparatus for treatment of ocular melanosis - The invention entails a novel system and method for modifying scleral pigmentation. More particularly, the invention entails a novel system and method for treating Ocular Melanosis (OM). The invention contemplates a system and method for treating OM that uses lasers with modified pulse widths and low power to whiten the sclera without causing damage to the retina. Ultimately, a system has been developed that uses of low laser pulse fluences considerably less than those used for treating nevus of Ota on the skin. The system limits the risk of retinal injury by use of (a) a small exposure spot size and (b) a high numerical aperture (NA) optical beam with fluences of between about 0.5 J/cm | 04-02-2009 |
| 20090299268 | Topical Aminolevulinic Acid-Photodynamic Therapy for the Treatment of Acne Vulgaris - Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered. | 12-03-2009 |
| 20100098677 | Methods and Devices for Epithelial Protection During Photodynamic Therapy - Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species. | 04-22-2010 |
| 20100174223 | METHOD AND APPARATUS FOR OPTICAL INHIBITION OF PHOTODYNAMIC THERAPY - A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue. Subsequent application of a treatment radiation can activate the photosensitizer to damage or destroy target sites while the non-target tissue remains substantially unaffected. | 07-08-2010 |
| 20100217065 | MAGNETIC INK TISSUE MARKINGS - The invention provides tissue markings (such as tattoos) comprising magnetic particles, e.g., magnetite, and methods for making and altering, e.g., removing them. | 08-26-2010 |
| 20110009847 | SYSTEMS AND METHODS FOR CREATING AND USING SUCTION BLISTERS OR OTHER POOLED REGIONS OF FLUID WITHIN THE SKIN - The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor. | 01-13-2011 |
| 20110224656 | METHOD AND APPARATUS FOR SELECTIVE PHOTOTHERMOLYSIS OF VEINS - Exemplary embodiments of the present disclosure provide method and apparatus for providing electromagnetic radiation to a biological tissue that may be selectively absorbed by venous structures as compared to arteries. For example, a wavelength of the electromagnetic radiation can be selected based on absorptivity of the radiation by oxygenated hemoglobin, deoxygenated hemoglobin, and/or met-hemoglobin. The wavelength can be, e.g., between about 685 nm and about 705 nm, or between about 690 nm and about 700 nm, or about 694 nm. The exemplary methods and apparatus can be used, e.g., for photothermolysis treatment of venous structures such as port wine stains or varicose veins, while reducing or avoiding undesirable damage to nearby arteries in the irradiated tissue. | 09-15-2011 |
| 20110251602 | METHOD AND APPARATUS FOR TISSUE EXPANSION - Exemplary embodiments of the present disclosure provide method and apparatus for facilitating stretching of a bio-logical tissue by forming a plurality of micro-slits in the tissue. Each micro-slit can be less than about 2 mm or less than about 1.5 mm long, or even less than about 1 mm, such that small gaps that can heal quickly can be formed when the tissue is stretched. The micro-slits can be formed using a plurality of cutting arrangements or an ablative laser. The micro-slits can be formed in various patterns, including staggered rows, circular or spiral patterns, or random patterns. | 10-13-2011 |
| 20110313429 | METHOD AND APPARATUS FOR TISSUE GRAFTING AND COPYING - Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue. | 12-22-2011 |
Richard S. Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110125974 | DISTRIBUTED SYMMETRIC MULTIPROCESSING COMPUTING ARCHITECTURE - Example embodiments of the present invention includes systems and methods for implementing a scalable symmetric multiprocessing (shared memory) computer architecture using a network of homogeneous multi-core servers. The level of processor and memory performance achieved is suitable for running applications that currently require cache coherent shared memory mainframes and supercomputers. The architecture combines new operating system extensions with a high-speed network that supports remote direct memory access to achieve an effective global distributed shared memory. A distributed thread model allows a process running in a head node to fork threads in other (worker) nodes that run in the same global address space. Thread synchronization is supported by a distributed mutex implementation. A transactional memory model allows a multi-threaded program to maintain global memory page consistency across the distributed architecture. A distributed file access implementation supports non-contentious file I/O for threads. These and other functions provide a symmetric multiprocessing programming model consistent with standards such as Portable Operating System Interface for Unix (POSIX). | 05-26-2011 |
Rose Anderson, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100126043 | Articles of Footwear - An article of footwear promotes complimentary movement and proprioceptive feedback of a user's foot (e.g., to help an infant learn to walk or an adult balance on an uneven surface) while wearing the article of footwear. The article of footwear includes an outsole having a forefoot region, a heel region, and a mid region substantially in between the forefoot and heel regions. The three regions are configured to provide complimentary movement with respect to the user's foot. The forefoot region of the outsole includes a base portion interconnecting ground contact pads configured to move relative to one another, each ground contact pad moving substantially independently of the other relative to the base portion. | 05-27-2010 |
Rose Anderson, Melrose, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100016815 | THIN FILM WOUND DRESSING - A composite wound dressing and delivery apparatus includes a substantially transparent dressing layer having a lower surface that is coated with a pressure sensitive for applying the dressing layer over a wound to define a reservoir in which a negative pressure may be maintained. A substantially transparent backing layer adhered to the lower surface of the dressing layer in a releasable manner, and a vacuum port is centrally located on the dressing layer. The vacuum port is adapted to provide fluid communication between a vacuum source and the reservoir through the dressing layer. A targeting grid associated with either the dressing layer or the backing layer includes regularly spaced reference marks along at least two axes extending from the vacuum port. | 01-21-2010 |
| 20110313339 | Thin Film Wound Dressing - A composite wound dressing and delivery apparatus includes a substantially transparent dressing layer having a lower surface that is coated with a pressure sensitive for applying the dressing layer over a wound to define a reservoir in which a negative pressure may be maintained. A substantially transparent backing layer adhered to the lower surface of the dressing layer in a releasable manner, and a vacuum port is centrally located on the dressing layer. The vacuum port is adapted to provide fluid communication between a vacuum source and the reservoir through the dressing layer. A targeting grid associated with either the dressing layer or the backing layer includes regularly spaced reference marks along at least two axes extending from the vacuum port. | 12-22-2011 |
R. R. Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090259167 | METHODS AND COMPOSITIONS FOR DOSE-DEPENDENT PHOTODYNAMIC THERAPY OF DISORDERS - The invention provides methods and compositions for treating a tissue disorder in a subject by parenterally administering a solution of aminolevulinic acid (ALA) or a derivative thereof that is not greater than 1.0 percent by weight into a local subcutaneous or dermal region of the subject; and administering high fluence light to said bodily area to produce a phototoxic species in said local region, thereby treating a tissue disorder in the subject. | 10-15-2009 |
R. Rox Anderson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090024193 | Method And Apparatus For Photothermal Treatment Of Tissue At Depth - The present invention provides method and apparatus for treating tissue in a region at depth by applying optical radiation thereto of a wavelength able to reach the depth of the region and of a selected relatively low power for a duration sufficient for the radiation to effect the desired treatment while concurrently cooling tissue above the selected region to protect such tissue. Treatment may be enhanced by applying mechanical, acoustic or electrical stimulation to the region. | 01-22-2009 |
| 20100228326 | HEADS FOR DERMATOLOGY TREATMENT - Methods and apparatus for dermatology treatment are provided which involve the use of continuous wave (CW) radiation, preheating of the treatment volume, precooling, cooling during treatment and post-treatment cooling of the epidermis above the treatment volume, various beam focusing techniques to reduce scattering and/or other techniques for reducing the cost and/or increasing the efficacy of optical radiation for use in hair removal and other dermatological treatments. A number of embodiments are included for achieving the various objectives indicated above. | 09-09-2010 |
| 20110319877 | APPARATUS AND METHOD FOR LASER TREATMENT WITH SPECTROSCOPIC FEEDBACK - A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system. | 12-29-2011 |
| 20120083862 | HEADS FOR DERMATOLOGY TREATMENT - Methods and apparatus for dermatology treatment are provided which involve the use of continuous wave (CW) radiation, preheating of the treatment volume, precooling, cooling during treatment and post-treatment cooling of the epidermis above the treatment volume, various beam focusing techniques to reduce scattering and/or other techniques for reducing the cost and/or increasing the efficacy of optical radiation for use in hair removal and other dermatological treatments. A number of embodiments are included for achieving the various objectives indicated above. | 04-05-2012 |
R. Rox Anderson, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080269733 | METHOD AND APPARATUS FOR TREATING WRINKLES IN SKIN USING RADIATION - A method for treating wrinkles in skin involves the use of a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region. | 10-30-2008 |
| 20110137230 | Method and Apparatus for Medical Treatment Utilizing Long Duration Electromagnetic Radiation - A method and apparatus are provided for performing a medical procedure on a patient, for example a dermatological procedure, by use of electromagnetic radiation (EMR) having a relatively low peak power, and in particular a peak power low enough so as not to result in a phase change in the heater or chromophore absorbing radiation which would result in a significant reduction in its absorption, and of relatively long duration which is generally greater than, sometimes significantly greater than, the thermal relaxation time of the irradiated target. | 06-09-2011 |
| 20110172651 | Heads For Dermatology Treatment - Methods and apparatus for dermatology treatment are provided which involve the use of continuous wave (CW) radiation, preheating of the treatment volume, precooling, cooling during treatment and post-treatment cooling of the epidermis above the treatment volume, various beam focusing techniques to reduce scattering and/or other techniques for reducing the cost and/or increasing the efficacy of optical radiation for use in hair removal and other dermatological treatments. A number of embodiments are included for achieving the various objectives indicated above. | 07-14-2011 |
Stephen J. Anderson, Holliston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080221627 | SURGICAL INSTRUMENT FOR MOVING VERTEBRAE - A surgical instrument extendable through a cannula for moving a first bone portion relative to a second bone portion includes a first portion having a longitudinal axis engageable with a first member connected with to the first bone portion. A second portion is engageable with a second member connected with the second bone portion. The second portion is movable relative to the first portion from a first position toward a second position to move the first and second bone portions away from each other. An actuator connected with the second portion moves the second portion relative to the first portion in a direction extending transverse to the longitudinal axis. | 09-11-2008 |
Sterling J. Anderson, Allston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100228427 | PREDICTIVE SEMI-AUTONOMOUS VEHICLE NAVIGATION SYSTEM - An active safety framework performs trajectory planning, threat assessment, and semi-autonomous control of passenger vehicles in a unified, optimal fashion. The vehicle navigation task is formulated as a constrained optimal control problem. A predictive, model-based controller iteratively plans an optimal or best-case vehicle trajectory through the constrained corridor. This best-case scenario is used to establish the minimum threat posed to the vehicle given its current state, current and past driver inputs/performance, and environmental conditions. Based on this threat assessment, the level of controller intervention required to prevent collisions or instability is calculated and driver/controller inputs are scaled accordingly. This approach minimizes controller intervention while ensuring that the vehicle does not depart from a traversable corridor. It also provides a unified architecture into which various vehicle models, actuation modes, trajectory-planning objectives, driver preferences, and levels of autonomy can be seamlessly integrated without changing the underlying controller structure. | 09-09-2010 |
| 20120083947 | INTEGRATED FRAMEWORK FOR VEHICLE OPERATOR ASSISTANCE BASED ON A TRAJECTORY AND THREAT ASSESSMENT - Various types and levels of operator assistance are performed within a unified, configurable framework. A model of the device with a model of the environment and the current state of the device and the environment are used to iteratively generate a sequence of optimal device control inputs that, when applied to a model of the device, generate an optimal device trajectory through a constraint-bounded corridor or region within the state space. This optimal trajectory and the sequence of device control inputs that generates it is used to generate a threat assessment metric. An appropriate type and level of operator assistance is generated based on this threat assessment. Operator assistance modes include warnings, decision support, operator feedback, vehicle stability control, and autonomous or semi-autonomous hazard avoidance. The responses generated by each assistance mode are mutually consistent because they are generated using the same optimal trajectory. | 04-05-2012 |
| 20120109610 | METHODS AND APPARATI FOR PREDICTING AND QUANTIFYING THREAT BEING EXPERIENCED BY A MODELED SYSTEM - A method predicts and quantifies the threat posed to a human-operated device based on an optimal device trajectory through a constraint-bounded corridor. A model of the device together with a model of anticipated hazards and the current state of both the device and the hazards are used to iteratively generate an optimal device trajectory through a constraint-bounded corridor or region within state space. Device dynamics are forward-simulated over a time horizon. A method generates a threat assessment metric from the resulting sequence of optimal vehicle states. This threat assessment may be used to devise various types and levels of operator assistance. The human operator can control the device within a safe corridor or region. Threat assessment is based on the nearness of successive optimal trajectory predictions to limits of safe device handling rather than on deviation from a predefined path. | 05-03-2012 |
Steven Anderson, Worcester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110213358 | Tissue-Treatment Methods - Polymer insulators and methods of using polymer insulators are disclosed. In some embodiments, a method includes separating a first portion of a subject's tissue from a second portion of the subject's tissue so that there is a space between the first and second portions of tissue. Deionized water, a buffered saline solution, liquid polymers, gels, particles, foams, and/or gases are disposed between the first and second portions of tissue, and the first portion of tissue is exposed to energy to treat the first portion of tissue. | 09-01-2011 |
Theodore R. Anderson, Brookfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090134803 | Plasma device with low thermal noise - A plasma device having low thermal noise, which results in a high signal-to-noise ratio (SNR) of the plasma device. The plasma device includes devices with a plasma that is responsive to electromagnetic radiation and/or electrical signals. In various configurations, the plasma device has a plasma in which the temperature, resistance, pressure, and/or collision frequency are at a level sufficiently low to produce an acceptable level of noise. In another configuration, the operating frequency of the plasma device is at a level sufficiently high to produce an acceptable level of noise. Decreasing the noise level results in increasing the signal-to-noise ratio and increasing the data rate. The plasma temperature is reduced by operating the plasma device in the afterglow state. The plasma electron temperature is reduced by confining high energy electrons in a potential well and by using an electron emitting filament. | 05-28-2009 |
| 20110025565 | PLASMA DEVICES FOR STEERING AND FOCUSING ANTENNA BEAMS - A plasma array of plural plasma containers of selected shapes and a selected spacial distribution, contain variable plasma density within each container and from one container to the next for establishing plasma frequency ranges from zero to an arbitrary plasma frequency. The plasma array is operating in a mode to transmit, receive, filter, reflect and/or refract radiation. | 02-03-2011 |
Troy G. Anderson, Marblehead, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080314808 | Portable, refillable water dispenser serving batches of water purified of organic and inorganic pollutants - A portable, refillable water dispenser serving batches of water purified of organic and inorganic pollutants includes a portable, refillable and hand-holdable vessel for holding and pouring water having a spout and, inside the portable, refillable and hand-holdable vessel, moving water and still water processing module cooperative to remove inorganic and organic pollutants from water received batchwise by the vessel. | 12-25-2008 |
Troy Gene Anderson, Mablehead, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090208030 | Customizability digital sound relaxation system - In one embodiment, an improved-customizability digital sound relaxation system having a sound card receiving port and a collectable sound card are cooperative to play prerecorded natural or other sounds by depressing one of a plurality of sound selector switches and a sound card selector switch. The new sounds of each collectable sound card customize the library of available sounds to individual taste. In another embodiment, an improved-flexibility digital sound relaxation system having at least two (2) prerecorded sounds stored at first and second memory locations of internal or external/internal memory devices may be selected and combined for concurrent and/or individual replay by depressing one of a plurality of sound selector switches and a combine switch, or by depressing one of a plurality of sound selector switches, a sound card selector switch and a combine switch. In this manner, from eighteen (18) digitally prerecorded sounds of the preferred embodiment ninety (90) individually selectable and/or combinable sounds are made available. In either embodiment, natural or other sounds may be stored in loop or sound bite format in either or both of the internal and external memories. | 08-20-2009 |
Troy Gene Anderson, Marblehead, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100222640 | DIGITAL SOUND RELAXATION AND SLEEP-INDUCING SYSTEM AND METHOD - In one embodiment, an improved-customizability digital sound relaxation system having a sound card receiving port and a collectable sound card are cooperative to play prerecorded natural or other sounds by depressing one of a plurality of sound selector switches and a sound card selector switch. The new sounds of each collectable sound card customize the library of available sounds to individual taste. In another embodiment, an improved-flexibility digital sound relaxation system having at least two (2) prerecorded sounds stored at first and second memory locations of internal or external/internal memory devices may be selected and combined for concurrent and/or individual replay by depressing one of a plurality of sound selector switches and a combine switch, or by depressing one of a plurality of sound selector switches, a sound card selector switch and a combine switch. In this manner, from eighteen (18) digitally prerecorded sounds of the preferred embodiment ninety (90) individually selectable and/or combinable sounds are made available. In either embodiment, natural or other sounds may be stored in loop or sound bite format in either or both of the internal and external memories. In a further sound relaxation and sleep-inducing embodiment, first and second preselected sound patterns selected respectively to mask sound and soothe the listener and to induce a state of deep relaxation that helps the listener to fall asleep may be selected by depressing combination mode select and sequential sound selector switches. In alarm mode, sound select and alarm check buttons respectively allow any sound of the library of prerecorded sounds (sound card or internal, single or mixed) to be selected as the alarm wake-up sound and one-touch alarm status display and audible alarm replay of any sound selected at wake-up volume in sound wake-up mode. | 09-02-2010 |
Warren R. Anderson, Westborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090154626 | CONTINUOUS RECEIVER CLOCK ALIGNMENT AND EQUALIZATION OPTIMIZATION - The available bandwidth of an Input/Output (I/O) communications link is increased by removing the need for retraining events on a communications link. This results in removing a potentially severe system performance degradation penalty that may occur from data traffic stoppage during the retraining events. The available bandwidth is further increased by removing a timing error which results in increasing a timing margin for other components. This results in an increase in the maximum speed of systems with high speed I/O and communication transceiver Integrated Circuits (IC)s. | 06-18-2009 |
| 20120002334 | ELECTROSTATIC DISCHARGE CIRCUIT - An integrated circuit (IC) is disclosed. The IC includes a first global voltage node and a second global voltage node. The IC further includes two or more power domains each coupled to the first global voltage node. Each of the two or more power domains includes a functional unit and a local voltage node coupled to the functional unit. Each of the plurality of power domains further includes a power-gating transistor coupled between the local voltage node and the second global voltage node, and an ESD (electrostatic discharge) circuit configured to detect an occurrence of an ESD event and further configured to cause activation of the transistor responsive to detecting the ESD event. | 01-05-2012 |
Zackary Anderson, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100072760 | Regenerative shock absorber system - A regenerative shock absorber that include a housing and a piston that moves at least partially through the housing when the shock is compressed or extended from a rest position. When the piston moves, hydraulic fluid is pressurized and drives a hydraulic motor. The hydraulic motor, in turn, drives an electric generator that produced electric energy. The electric energy may be provided to a vehicle, among other things. The regenerative shock absorber may also provide ride performance that comparable to or exceeds that of conventional shock absorbers. | 03-25-2010 |
Zackary M. Anderson, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100262308 | SYSTEM AND METHOD FOR CONTROL FOR REGENERATIVE ENERGY GENERATORS - A device and system that can dynamically provide variable load on a generator and intelligently distribute generated power to loads and energy storage devices is disclosed. One system includes load profile controllers that employ a switching strategy to dynamically vary the load the generator induces while producing regenerative energy. This switching strategy may allow for a wide dynamic range of configurable damping characteristics, as well as decouple generator damping and the system output power. Multiple load profile controllers can be used together via a communications network, such as a vehicle controller area network (CAN) bus. A central regeneration controller or existing electronic control unit (ECU) can issue commands to change damping performance in different load profile controllers. By networking multiple load profile controllers together in either a distributed or centralized manner, the system may allow for intelligent power routing, coordination of multiple energy-generating devices (such as regenerative shocks and brakes), and improved utilization of on-board energy storage devices. | 10-14-2010 |