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Anatol Kontush, Paris FR
| Patent application number | Description | Published |
|---|---|---|
| 20100179066 | Method for Assessing the Risk of a Cardiovascular Disease and for Diagnosing Dyslipidemia - The invention relates to a method for assessing the risk of a cardiovascular disease and/or for diagnosing dyslipidemia in a patient, said method comprising: a) isolating in a blood sample obtained from said patient the high density lipoprotein (HDL) fraction or a subfraction thereof; and b) measuring in said HDL fraction or subfraction thereof the concentration of one or more biomarkers selected from the group consisting of Sphingosine-1-Phosphate (S1P), sphingomyelin (SM) and Apolipoprotein A-I (apoA-1). | 07-15-2010 |
Anatol Koutychenko, Moscow RU
| Patent application number | Description | Published |
|---|---|---|
| 20090137779 | Peptide inhibitors of thrombin as potent anticoagulants - The tetrapeptide Phe-Asn-Pro-Arg (SEQ ID NO: 3) is a structurally-optimized sequence for binding to the active site of thrombin. By conjugating this tetrapeptide or variants thereof to a C-terminal fragment of hirudin, we were able to generate a series of new multivalent inhibitors of thrombin containing only genetically encodable natural amino acids. We found that synergistic binding to both the active site and an exosite of thrombin can be enhanced through substitutions of amino acid residues at the P | 05-28-2009 |
Anatol Krozer, Goteborg SE
| Patent application number | Description | Published |
|---|---|---|
| 20090085557 | DETECTION DEVICE AND METHOD - The present invention relates to method and device for detecting changes of a magnetic response of at least one magnetic particle in a carrier fluid. The method comprises: using a measuring procedure comprising measuring the characteristic rotation time of said magnetic particle, said measuring procedure further involving measuring Brownian relaxation in said carrier fluid under influence of an external pulsed excitation magnetic field, and based on said influence of said external pulsed excitation magnetic field measuring a hydrodynamic volume of a particle or a change in a hydrodynamic volume of the particle change upon modification of an effective volume of the particle or its interaction with said carrier fluid by detecting change of magnetization of the particle with time by monitoring change of an output signal in detection coil. | 04-02-2009 |