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Anastasia

Anastasia Daifotis, Westfield, NJ US

Patent application numberDescriptionPublished
20080255072Composition for Inhibition of Cathepsin K - The present invention relates to the a method of inhibiting bone resorption in a mammal in need thereof with an oral pharmaceutical composition comprising a cathepsin K inhibitor, or a pharmaceutically acceptable salt thereof, or a mixture thereof, according to a continuous schedule having a dosage interval of once weekly, biweekly, twice monthly or once monthly.10-16-2008

Anastasia Dedis, Lutz, FL US

Patent application numberDescriptionPublished
20090272798Method of Membership Management - Business method that allows a user to store the value of their membership on a card, to use when and where they wish to do so. This not only eliminates their financial risk, but also facilitates choosing one's own personal preferences out of their membership. A user can enjoy use tailored to a member's needs and receive value for money. The present invention enables a user to store the value of their membership on an Access Card so that one only pays for the services used. Key components of the business method of the present invention include: inter-member networking capabilities for the members through a personal web page and member and partner communication where each member can select the partners that interest them and give them commercial communication access through the member's personal page and in exchange the selected partners give these members offers/discounts in exchange for other non-monetary compensation.11-05-2009
20090327928Method and System Facilitating Two-Way Interactive Communication and Relationship Management - A tool, method, and system that facilitates two-way interactive brokered commercial communication network between consumers and commercial entities. A Leaf holds all commercial relationship information and any relevant to the specific Seller information. A Relationship Tree is an organizer as well as a communications tool. A Tree can be turned to lists by clicking one of the controls. Each Branch can be isolated and enlarged by clicking on it, for better viewing. The leafs are placed on the tree by the owner who can drag and drop in the desired place. Each new leaf awaits under the tree to be hung in the desired place by the tree owner and generate a relationship code. Different Trees can be used for different purposes each escorted by relevant tools and gadgets.12-31-2009
20110161827SOCIAL MEDIA COMMUNICATION AND CONTACT ORGANIZATION - An apparatus, system, and method and for social media communication and contact organization. The method includes representing a user contact as a node in an organizational structure on a web-based social networking platform. The organization structure may be associated with a user. The organizational structure may include a base with one or more clusters, each cluster configured to hold one or more nodes. The method includes grouping the node into a particular cluster of the organizational structure. The node includes one or more information channels between the user contact and the user. The method includes graphically depicting the organizational structure. The graphically depicted organizational structure may be responsive to interaction from the user.06-30-2011

Anastasia Kalaskani, Pallini Attikis GR

Patent application numberDescriptionPublished
20110065751Improved pharmaceutical composition containing a selective estrogen receptor modulator and method for the preparation thereof - The present invention relates to a pharmaceutical formulation of solid dosage forms comprising a therapeutically effective amount of a selective estrogen receptor modulator, and especially Raloxifene or a pharmaceutical acceptable salt thereof, in combination with a super disintegrant such as Primojel, and a process for the preparation thereof by wet granulation.03-17-2011

Anastasia Khvorova, Westborough, MA US

Patent application numberDescriptionPublished
20110237522NEUTRAL NANOTRANSPORTERS - Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.09-29-2011
20110237648RNA INTERFERENCE IN SKIN INDICATIONS - The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.09-29-2011

Anastasia Khvorova, Northborough, MA US

Patent application numberDescriptionPublished
20110039914MODIFIED RNAI POLYNUCLEOTIDES AND USES THEREOF - The invention relates to improved RNAi constructs and uses thereof. The construct has a double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and preferably blunt-ended. The construct has selective minimal modifications to confer an optimal balance of biological activity, toxicity, stability, and target gene specificity. For example, the sense strand may be modified (e.g., one or both ends of the sense strand is/are modified by four 2′-O-methyl groups), such that the construct is not cleaved by Dicer or other RNAse III, and the entire length of the antisense strand is loaded into RISC. In addition, the antisense strand may also be modified by 2′-O-methyl group at the 2nd 5′-end nucleotide to greatly reduce off-target silencing. The constructs of the invention largely avoids the interferon response and sequence-independent apoptosis in mammalian cells, exhibits better serum stability, and enhanced target specificity.02-17-2011
20110160285IDENTIFICATION OF MIRNA PROFILES THAT ARE DIAGNOSTIC OF HYPERTROPHIC CARDIOMYOPATHY - Disclosed herein are a collection of miRNAs and genes whose expression is altered in hypertrophic cardiomyopathy. Accordingly, these miRNAs and genes, singly or in combination, are useful as molecular markers for diagnosis or prognosis of hypertrophic cardiomyopathy. The miRNAs and genes disclosed can also be therapeutic targets for cardiac hypertrophy. For example, agents such as miRNA mimics, miRNA inhibitors or siRNAs for a given miRNA or gene can be used to modulate the level of these molecules thereby inhibiting or preventing hypertrophic cardiomyopathy.06-30-2011
20110172289MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS - Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.07-14-2011
20110251258RNAI CONSTRUCTS AND USES THEREOF - The invention relates to improved double-stranded RNAi constructs (sometimes referred to as “solo-rxRNA”) and uses thereof. The construct comprises a structure formed in some aspects of the invention by two identical single-stranded polynucleotides, with the structure having two double-stranded stem regions (each having less than 21 base pairs) and a loop or bulge having about 4 to 11 nucleotides on each strand. The construct is resistant to cleavage by Dicer or other Dicer-like RNase III enzymes and is capable of being loaded into a RISC complex to effect RNA interference. In addition, the nucleotides of the present hairpin constructs may be modified to greatly enhance functionality, such as stability and specificity.10-13-2011

Anastasia Kolesnichenko, Kiev UA

Patent application numberDescriptionPublished
20090229783METHOD AND SYSTEM OF ELECTROMAGNETIC STIRRING FOR CONTINUOUS CASTING OF MEDIUM AND HIGH CARBON STEELS - A method and an apparatus are provided for electromagnetic stirring during a continuous casting process, especially for casting a billet and bloom of medium and high carbon steels. The method and apparatus provide a higher surface quality of the ingot, reduce the entrapping of nonmetallic inclusions into the ingot, and suppress issues regarding central segregation and central porosity. The method provides an improvement in the stirring process from the meniscus to the crater end—and relates to in-mold stirring and stirring in a zone of secondary cooling and up to the crater end. The in-mold stirring is geared towards the suppression of meniscus disturbance, for submerged casting, in particular, the reducing of helical and axial velocity components of the molten steel, the lowering of the initial solidification point to avoid the touching of a shell edge with the slag ring, and a decrease of oscillation marks.09-17-2009

Anastasia Murat, Bale CH

Patent application numberDescriptionPublished
20110076283METHOD FOR PREDICTING AND DIAGNOSING BRAIN TUMOR - The present invention relates to a method for predicting or diagnosing outcome of concomitant chemo-radiotherapy of a subject suffering from brain tumor. The present invention further relates to compositions and methods for treatment or prevention of tumor resistance in a subject suffering from a brain tumor and to a kit useful for predicting or diagnosing the tumor resistance in a subject treated with concomitant chemo-radiotherapy.03-31-2011

Anastasia Paushkina, Redmond, WA US

Patent application numberDescriptionPublished
20100082604AUTOMATIC SEARCH QUERY SUGGESTIONS WITH SEARCH RESULT SUGGESTIONS FROM USER HISTORY - Suggested search results are provided with suggested search queries as a user incrementally enters characters of a search query. At each incremental user input, a query portion is received and suggested search queries are identified based on the query portion. Suggested search results associated with the suggested search queries are also identified. These suggested search results enable direct navigation to web sites associated with the search results. In some embodiments, a user's search history is analyzed to identify search results selected by the user for the suggested search queries. In other embodiments, search histories for a group of users associated with the user are analyzed to identify the suggested search results to provide with the suggested search queries.04-01-2010

Anastasia Soare, Beverly Hills, CA US

Patent application numberDescriptionPublished
20090044820Stencils and gauging device for aesthetically pleasing eyebrow shaping - A novel gauging device and associated stencils facilitate the shaping of eyebrows according to a Golden Ratio standard. The gauging device is adapted to be placed over a woman's face and maintained in a fixed position relative to her eyes and nose. A nosepiece and knobs are adjusted such that a lower end of a guide rod may be rotated about various points relative to the nose and held in predetermined angles relative to the nose and eyes, possibly supported magnetically on a lower track adjacent the nostrils and an upper track above the eyebrows. An eyebrow stencil is held in a desired position relative to the previously positioned guide rod, which facilitates convenient application and symmetrical shaping, preferably with frictional clamps for permitting the stencil to be shifted in place so that a particular portion of the stencil is properly aligned with the guide rod after the guide rod has been aligned with an appropriate Golden Ratio marking on the stencil. Each stencil may be provided with more than one set of such markings to accommodate not only different eyebrows of different sizes, but also to adjust the eyebrow's ideal Golden Ratio “High Point” to complement facial proportions (preferably represented by a single Facial Ratio Value or “FRV” that takes into account several different measured ratios) that deviate substantially from an ideal Golden Ratio. A slim tab between the upper and the lower edges of the stencil cut-out preferably provides a convenient reference mark for the “High Point” of the unadjusted cut-out.02-19-2009

Anastasia Tyurina, Needham, MA US

Patent application numberDescriptionPublished
20110254969POINT SOURCE DETECTION - The invention provides a technique for accurate detection of objects appearing in the image, such as single fluorescent molecules, cells, microorganisms, nucleotides, DNA strands, or stars in celestial images. The method allows to differentiate between two combined point sources even if they are closer to each other than the optical resolution of the system. The procedure involves computing several coefficients representing decomposition of the intensity data in the basis of Hermit functions. In the case when the objects are distributed randomly and higher yield of accurately detected objects is desired, the method allows for a tenfold increase in such yield.10-20-2011

Anastasia Valeniza, San Diego, CA US

Patent application numberDescriptionPublished
20090029985PYRIDAZINE COMPOUNDS AND METHODS - The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.01-29-2009

Anastasia Velentza, San Diego, CA US

Patent application numberDescriptionPublished
20080318899Pyridazine Compounds, Compositions and Methods - The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.12-25-2008

Anastasia Velentza, Chicago, IL US

Patent application numberDescriptionPublished
20100317665Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death - A novel class of pyridazine compositions and related methods of use.12-16-2010

Anastasia Voskobojnik, Oehringen DE

Patent application numberDescriptionPublished
20110059911Antiinfective and Antitumoral Compounds Isolated From Tropical Lianas - The present invention relates to naphthoquinone derivatives isolated from solid callus cultures from two species of the palaeotropical plant families Dioncophyllaceae and Ancistrocladaceae. It further relates to methods of their production as well as to their use as antiinfective and antitumoral pharmaceuticals.03-10-2011