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Amphlett
Godfrey Amphlett, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090142361 | DRUG CONJUGATE COMPOSITION - The invention provides a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human the reconstituted composition such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed. | 06-04-2009 |
| 20110166319 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, holding steps, and optionally a tangential flow filtration (TFF) step. | 07-07-2011 |
Godfrey W. Amphlett, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110021744 | PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES - The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step. | 01-27-2011 |
Steven Andrew Amphlett, West Sussex GB
| Patent application number | Description | Published |
|---|---|---|
| 20100063790 | METHOD OF SIMULATING ENGINE OPERATION - A method of creating a simplified computer implement for engine model comprises obtaining a complete computer implement for engine model ( | 03-11-2010 |