Patent application number | Description | Published |
20090076142 | USE OF THE IRRITATING PRINCIPAL OLEOCANTHAL IN OLIVE OIL, AS WELL AS STRUCTURALLY AND FUNCTIONALLY SIMILAR COMPOUNDS - The invention provides methods of synthesizing the purified enantiomers of oleocanthal. The invention further provides methods of using oleocanthals in various formulations including, food additives; pharmaceuticals; cosmetics; animal repellants; and discovery tools for mammalian irritation receptor genes, gene products, alleles, splice variants, alternate transcripts and the like. | 03-19-2009 |
20090163563 | Phorboxazole Compounds and Methods of Their Preparation - Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division. | 06-25-2009 |
20090187031 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof - Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided. | 07-23-2009 |
20090306014 | C-10 CARBAMATES OF TAXANES - Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy. | 12-10-2009 |
20110020424 | USE OF THE IRRITATING PRINCIPAL OLEOCANTHAL IN OLIVE OIL, AS WELL AS STRUCTURALLY AND FUNCTIONALLY SIMILAR COMPOUNDS - The invention provides oleocanthal analogs and methods of using oleocanthals in various formulations including, food additives; pharmaceuticals; cosmetics; animal repellants; and discovery tools for mammalian irritation receptor genes, gene products, alleles, splice variants, alternate transcripts and the like. | 01-27-2011 |
20110172220 | DISCODERMOLIDE ANALOGUES AND METHODS OF THEIR USE - 6- and 7-substituted coumarin and related 6- and 7-substituted 1H-quinolin-2-one compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the 7-substituted coumarin and related 7-substituted 1H-quinolin-2-one compounds mimic or exceed the high level of pharmacological activity of discodermolide. In other embodiments, their preparation involves more readily available materials, higher yield processes and/or simpler synthetic sequences. In yet other embodiments, the compounds of the invention represent structurally simpler, therapeutically active analogues of discodermolide than heretofore known and may be useful as microtubule stabilizers and, inter alia, for treating and/or preventing cancer and other diseases, disorders, and/or conditions mediated by the stabilization of microtubules. | 07-14-2011 |
20120122834 | SMALL MOLECULE CD4 MIMETICS AND USES THEREOF - The invention provides for compounds of formula I: wherein Z is absent or (CR | 05-17-2012 |
20120329877 | Cycloalkyl-dione Derivatives And Methods Of Their Use - The present invention is directed to compounds of formula I: | 12-27-2012 |
20130029983 | AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY - The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula I: | 01-31-2013 |
20130030027 | HEMI-PHORBOXAZOLE A DERIVATIVES AND METHODS OF THEIR USE - The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C | 01-31-2013 |
20130165489 | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof - The present invention includes a method of inhibiting, suppressing or preventing a viral infection in a subject, comprising administering to the subject a pharmaceutical composition comprising one or more of the compounds useful within the invention. | 06-27-2013 |
20140350113 | CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF - Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556. | 11-27-2014 |