Patent application number | Description | Published |
20100297697 | METHODS FOR INCREASING PROTEIN TITERS - The invention relates to methods of increasing the titre of a protein of interest in a cell as well as the improved production and purification of optimised biomolecules, one component of which is the domain C | 11-25-2010 |
20110201785 | METHOD FOR OPTIMIZING PROTEINS HAVING THE FOLDING PATTERN OF IMMUNOGLOBULIN - The invention relates to a method for optimizing the biophysical properties of molecules and derivatives of the Ig superfamily. The method is characterized in that as yet unrecognized helical structural elements with unknown structural, stability and folding roles have been identified as important determinants of correct and efficient structuring of antibody domains. The novel process for positively influencing the antibody properties and properties of other proteins that have the Ig folding pattern now consists of optimizing the properties of the short helical elements and in the transplantation of these elements between Ig domains. | 08-18-2011 |
20120071637 | SELECTIVE ENRICHMENT OF ANTIBODIES - The invention relates to a process for the selective concentration of immunoglobulins or other proteins that contain an Fc domain (target protein), comprising the following steps:
| 03-22-2012 |
20120295323 | Inactivation of Proteases - The invention relates to a process for inactivating proteases by repeatedly changing the pH in the cell culture supernatant at the start of the process for the purification of biopharmaceuticals. The pH is adjusted first to 3-5, and then to 7-9. | 11-22-2012 |
20130197197 | Chromatographic Method For Purifying FC-Containing Proteins - The present invention relates to methods of depleting impurities, in particular host cell proteins (HCP) and DNA from cell culture supernatants by means of protein A chromatography using a novel washing buffer. | 08-01-2013 |
20140128578 | SELECTIVE ENRICHMENT OF ANTIBODIES - The invention relates to a process for the selective concentration of immunoglobulins or other proteins that contain an Fc domain (target protein), comprising the following steps:
| 05-08-2014 |
Patent application number | Description | Published |
20100045163 | PHOSPHOR BODY CONTAINING RUBY FOR WHITE OR COLOUR-ON-DEMAND LEDS - The invention relates to a phosphor element comprising Cr(III)-activated aluminium oxide (ruby), to the production thereof, and to the use thereof as LED conversion phosphor for white LEDs or so-called colour-on-demand applications. | 02-25-2010 |
20100061077 | PHOSPHOR BODY BASED ON FLAKE FORM SUBSTRATES - The invention relates to a phosphor element which consists of natural and/or synthetic flake-form substrates, such as mica, corundum, silica, glass, ZrO | 03-11-2010 |
20100175587 | INTERFERENCE PIGMENTS - The present invention relates to interference pigments based on coated flake-form substrates which are distinguished by the fact in that they comprise
| 07-15-2010 |
20100244067 | PHOSPHOR PLATES FOR LEDS FROM STRUCTURED FILMS - The invention relates to a phosphor element which is based on natural and/or synthetic flake-form substrates, such as mica, corundum, silica, glass, ZrO | 09-30-2010 |
20100255047 | EFFECT PIGMENTS BASED ON COATED GLASS FLAKES - The present invention relates to effect pigments based on thin glass flakes and to a method for the production of such pigments. The resulting pigment can be used in any application for which pearlescent pigments have been heretofore used such as, for example, in plastics, paints, inks, cosmetic formulations, coatings including solvent or waterborne automotive paint systems, powder coatings, inks and agriculture foils. | 10-07-2010 |
20120010300 | EFFECT PIGMENTS BASED ON COATED GLASS FLAKES - The present invention relates to effect pigments based on thin glass flakes and to a method for the production of such pigments. The resulting pigment can be used in any application for which pearlescent pigments have been heretofore used such as, for example, in plastics, paints, inks, cosmetic formulations, coatings including solvent or waterborne automotive paint systems, powder coatings, inks and agriculture foils. | 01-12-2012 |
20130164356 | EFFECT PIGMENTS - The present invention relates to effect pigments which are based on flake-form substrates having a circular form factor of 1.2-2 and are coated with at least one high-refractive-index layer, and to the use thereof, inter alia in paints, coatings, printing inks, plastics and in cosmetic formulations. | 06-27-2013 |
20160068683 | EFFECT PIGMENTS - The present invention relates to effect pigments which are based on flake-form substrates having a circular form factor of 1.2-2 and are coated with at least one high-refractive-index layer, and to the use thereof, inter alia in paints, coatings, printing inks, plastics and in cosmetic formulations. | 03-10-2016 |
Patent application number | Description | Published |
20110077647 | Energized Needles for Wound Sealing - A bipolar electrosurgical instrument has a first and a second set of needle like structures. Each set of needle like structures is functional for puncturing the skin of a patient on opposing sides of a wound or cut. Each needle comprises a body and a pointed portion at a distal end. The distal end is structured to form a sealing surface with an opposing needle on a needle of the other set. The sealing surfaces are adapted to connect to an electrical energy source such that the sealing surfaces are capable of conducting bipolar energy therebetween. The first and second set of needle like structures are movable from a first position where the needles are disposed in spaced relation relative to one another to a second position where the first and second sets of needles members are closer to one another. A mechanical force applied to or within a housing is utilized to move the needles sets from the first position to the second position. | 03-31-2011 |
20120209263 | Surgical Instrument with Dispensable Components - A surgical instrument includes an active electrode coupled to a source of electrosurgical energy. The active electrode includes a tissue-contacting surface on an exterior surface of the instrument such that the tissue-contacting surface of the active electrode may intimately engage tissue. A replacement electrode includes a tissue-contacting surface, and is located in an interior cavity of the instrument. A seal is formed between the active electrode and the interior cavity of the instrument such that the tissue-contacting-surface of the replacement electrode is isolated from contamination exposed to the exterior of the instrument. The active electrode is removable from the instrument to expose the tissue-contacting surface of the replacement electrode, and the replacement electrode is connectable to the source of electrosurgical energy when the active electrode is removed. | 08-16-2012 |
20130085496 | Surgical Forceps - A forceps includes an end effector assembly having first and second jaw members, each jaw member including a tissue sealing plate disposed thereon. One or both of the jaw members is movable relative to the other between a spaced-apart position and an approximated position for grasping tissue therebetween. One or both of the jaw members defines a first channel extending therethrough and an opening in the tissue sealing plate thereof that is aligned with the first channel. A stop member having a pre-determined configuration is removably engaged within the first channel. At least a portion of the stop member is configured to extend through the opening of the tissue sealing plate to define a minimum gap distance between the tissue sealing plates of the jaw members when the jaw members are disposed in the approximated position. | 04-04-2013 |
20130177695 | Methods of Manufacturing End Effectors for Energy-Based Surgical Instruments - A method of manufacturing an end effector for a surgical instrument includes providing a substrate wherein at least an outer periphery of the substrate is formed from an electrically-insulative material. The method further includes forming at least one ridge on the outer periphery of the substrate and depositing an electrically-conductive material onto the at least one ridge to form at least one electrode. | 07-11-2013 |
Patent application number | Description | Published |
20160059359 | METHOD AND DEVICE FOR PROVIDING THROUGH-OPENINGS IN A SUBSTRATE AND A SUBSTRATE PRODUCED IN SAID MANNER - A method and device can create, with a laser beam, plural recesses in a substrate useful as an interposer, and a substrate produced thereby. A laser beam may be directed to the surface of a substrate. The duration of the laser beam effect is extremely short such that the substrate is only modified concentrically about the laser beam axis without reaching a substrate material recess. The laser beam is initially diverted by a transmission medium having a higher intensity-dependent refractive index than air, and subsequently reaching the substrate. Non-constant pulsed laser intensity increases to a maximum over the temporal course of the single pulse, then reduces; the refractive index also changes. The focus point of the laser beam moves between the outer surfaces of the substrate along the beam axis such that it reaches the desired modification along the beam axis without correcting the laser processing head in the z-axis. | 03-03-2016 |
20160060156 | METHOD AND DEVICE FOR SEPARATING A SUBSTRATE - A method and device for separating a substrate with a laser beam. The duration of the laser beam's effect is extremely short, so the substrate is only modified concentrically about the laser beam axis (Z) without it degrading the substrate material. While the laser beam acts upon the substrate, the substrate moves relative to a laser machining head, producing plural filament-type modifications along a separating surface to be incorporated. The laser beam is initially diverted by a transmission medium having a higher intensity dependent refractive index than air, then reaches the substrate. The non-constant pulsed laser intensity increases to a maximum over the temporal course of the single pulse, then reduces, and the refractive index changes. The laser beam focus point moves between the substrate's outer surfaces along the beam axis (Z), reaching the desired modification along the beam axis (Z) without correcting the laser machining head in the z-axis. | 03-03-2016 |