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Alving
Carl Alving, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080233142 | Use of penetration enhancers and barrier disruption methods to enhance the immune response of an antigen - A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a systemic or mucosol antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancement. | 09-25-2008 |
Carl R. Alving, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080274533 | T4 BACTERIOPHAGE BOUND TO A SUBSTRATE - T4 bacteriophages are bound to substrates such as liposomes using a binder. | 11-06-2008 |
| 20090081244 | Dry Formulation for Transcutaneous Immunization - A transcutaneous immunization system delivers antigen to immune cells through the skin, and induces an immune response in an animal or human. For example, skin-active adjuvant (e.g., an ADP-ribosylating exotoxin) can be used to induce an antigen-specific immune response (e.g., humoral and/or cellular effectors) after transcutaneous application of a dry formulation containing antigen and adjuvant to skin of the animal or human. The dry formulation may be a powder or a unit-dose patch. Use of adjuvant is not required if the antigen is sufficiently antigenic. Transcutaneous immunization may be induced with or without penetration enhancement | 03-26-2009 |
Kim Alving, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080219992 | Pancreatic cancer secreted targets and uses thereof - The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas. | 09-11-2008 |
Lex Alving, Mierlo NL
| Patent application number | Description | Published |
|---|---|---|
| 20110108735 | HIGH DYNAMIC RANGE X-RAY DETECTOR WITH IMPROVED SIGNAL TO NOISE RATIO - An x-ray detector and its pixel circuit are described, that allow to cover a large dynamic range with automatic selection of the sensitivity setting in each pixel, thus providing improved signal to noise ratio with all exposure levels. X-ray detectors are required to cover a large dynamic range. The largest exposure determines the required pixel capacitance. However, a large pixel capacitance gives a bad signal to noise ratio with small exposures e.g. in the dark parts of the image. This invention disclosure describes several approaches to provide automatic sensitivity selection in the pixels. This ensures that low signals are stored in a small capacitor or read out with a high sensitivity with corresponding good signal to noise ratio, while larger signals are stored in larger capacitors or are read out with lower sensitivity so that no information is lost. | 05-12-2011 |