Alonso Martí
Covadonga Alonso Martí, Madrid ES
Patent application number | Description | Published |
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20110061136 | FUSION PROTEIN THAT DIRECTS VACCINE ANTIGENS TO ANTIGEN-PRESENTING CELLS, AND APPLICATIONS THEREOF - Fusion protein with directioning of vaccinal antigens toward antigen-presenting cells and the applications thereof. This invention relates to a gene construct that comprises, operatively bound, at least one nucleotide sequence (A) that encodes a polypeptide with SEQ ID NO: 1, which has a region that recognises the β chain of the class-II DR antigen present on the surface of antigen-presenting cells; and one nucleotide sequence (B) that encodes a vaccinal antigen of interest. Moreover, this invention relates to recombinant vectors useful for the expression of the gene construct of the invention, transgenic cells and plants transformed or transfected with said vectors, fusion proteins encoded by the gene construct of the invention and vaccines that comprise said fusion proteins. | 03-10-2011 |
20110203010 | INSECT-DERIVED PROMOTERS FOR FOREIGN PROTEINS EXPRESSION IN INSECT CELLS - Insect-derived promoters for foreign proteins expression in insect cells. Regulatory polynucleotide sequences which drive the expression of major insect proteins (hexamerins) at specific evolution stages of larva have been isolated from insects ( | 08-18-2011 |
Covadonga Alonso Martí, Madrid ES
Patent application number | Description | Published |
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20110061136 | FUSION PROTEIN THAT DIRECTS VACCINE ANTIGENS TO ANTIGEN-PRESENTING CELLS, AND APPLICATIONS THEREOF - Fusion protein with directioning of vaccinal antigens toward antigen-presenting cells and the applications thereof. This invention relates to a gene construct that comprises, operatively bound, at least one nucleotide sequence (A) that encodes a polypeptide with SEQ ID NO: 1, which has a region that recognises the β chain of the class-II DR antigen present on the surface of antigen-presenting cells; and one nucleotide sequence (B) that encodes a vaccinal antigen of interest. Moreover, this invention relates to recombinant vectors useful for the expression of the gene construct of the invention, transgenic cells and plants transformed or transfected with said vectors, fusion proteins encoded by the gene construct of the invention and vaccines that comprise said fusion proteins. | 03-10-2011 |
20120289459 | ANTIVIRAL PEPTIDES FROM AFRICAN SWINE FEVER VIRUS WHICH PREVENT THE BINDING OF THE VIRUS TO DLC8 - New antiviral peptides interfering the binding of the virus to DLC8. A high number of pathogenic agents of viral origin use the dynein based intracellular transport machinery at some point of their infective cycle. The present invention consists of a new antiviral therapy consisting in the inhibition of viral infections produced by those virus that use the dynein system by mechanisms of interference mainly by preventing the interaction between the viral protein and the cellular DLC8 protein. The present invention discloses for the first time the blocking of the function of this interaction by peptides whose sequence comprises or consists of the totality or a partial sequence of the viral protein corresponding to the binding domain with DLC8. | 11-15-2012 |
M. Covadonga Alonso Martí, Madrid ES
Patent application number | Description | Published |
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20140065175 | CARRIER PEPTIDES FOR CELL DELIVERY - The invention relates to the technological sector of the transport and delivery of molecules into cells, either at cytoplasm or at nucleus or inter-cells (cell to cell transport), using peptides binding proteins from the cell microtubule motor complex, preferably dynein-binding peptides, as carrier/delivery peptides; or functionalized structures, as nanoparticles, linked to said carrier/delivery peptides. This delivery can be useful in many technical fields comprising, among some others: diagnosis, therapy and pharmacology. | 03-06-2014 |