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Allen, MO

Bradley T. Allen, Warsaw, MO US

Patent application numberDescriptionPublished
20110177216MICROBIAL REDUCTION IN A PROCESSING STREAM OF A MILLED PRODUCT - A process for treating a milled product to reduce microbial activity at a high confidence level is disclosed. A sterile ready to eat milled product at a high confidence of sterility is also disclosed.07-21-2011

David Mark Allen, St. Louis, MO US

Patent application numberDescriptionPublished
20090188308APPARATUS AND METHOD FOR TESTING FUEL FLOW - Apparatus and method for testing fuel flow in a return or returnless fuel system. The apparatus comprises a primary flow passage having an inlet for connection to the fuel system for receiving fuel pumped by the fuel pump, and an outlet adapted for connection to the fuel system for flow of fuel to one or more fuel injectors. The apparatus includes a first device for measuring a rate of fuel flow through the primary flow passage, and a second device for measuring a fuel pressure in the primary flow passage. A bypass valve in the primary flow passage is movable between a first position in which the bypass passage is closed and a second position in which the bypass passage is open. The bypass valve is movable to its first position for testing fuel flow in a return flow system and to its second position for testing fuel flow in a returnless fuel flow system. Different embodiments of the apparatus and methods of using the apparatus are disclosed.07-30-2009

Diane E. Allen, St. Charles, MO US

Patent application numberDescriptionPublished
20080228002Metal Surfaces to Inhibit Ethylenically Unsaturated Monomer Polymerization - Materials for making apparatus and a method of inhibiting polymerization during manufacture, purification, handling and storage of subject ethylenically unsaturated monomers are disclosed. In particular, copper or metals containing copper, in the presence of oxygen, have inhibit undesired polymerization resulting in polymer fouling in apparatus used during the manufacture, purification, handling and storage of the monomers, such as acrylic acid, methacrylic acid, acrylic acid esters and methacrylic acid esters. The copper or copper alloys as described herein, in the presence of an oxygen-containing gas, exhibit self-inhibiting surface characteristics when used to make at least a portion of the apparatus to inhibit polymerization of the monomers in contact with the portion of the apparatus including such copper-containing metal.09-18-2008

Edward Allen, O'Fallon, MO US

Patent application numberDescriptionPublished
20110247094Transgenic Plants with Enhanced Agronomic Traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.10-06-2011

Edwards Allen, O'Fallon, MO US

Patent application numberDescriptionPublished
20080201801Invertebrate MicroRNAs - This invention provides plants having resistance to invertebrate pests. More specifically, this invention discloses a non-natural transgenic plant cell expressing at least one invertebrate miRNA in planta for suppression of a target gene of an invertebrate pest or of a symbiont associated with the invertebrate pest. Also provided are recombinant DNA constructs for expression of at least one invertebrate miRNA in planta, a non-natural transgenic plant containing the non-natural transgenic plant cell of this invention, a non-natural transgenic plant grown from the non-natural transgenic plant cell of this invention, and non-natural transgenic seed produced by the non-natural transgenic plants, as well as commodity products produced from a non-natural transgenic plant cell, plant, or seed of this invention. This invention further provides a method of suppressing at least one target gene of an invertebrate pest of a plant or of a symbiont associated with the invertebrate, including providing a plant including the non-natural transgenic plant cell of this invention, wherein the invertebrate is the invertebrate pest, the recombinant DNA is transcribed in the non-natural transgenic plant cell to the recombinant miRNA precursor, and when the invertebrate pest ingests the recombinant miRNA precursor, the at least one target gene is suppressed.08-21-2008
20080229456Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.09-18-2008
20090013434Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.01-08-2009
20090070898Plant microRNAs and methods of use thereof - This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention.03-12-2009
20100223694Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.09-02-2010
20110035838Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.02-10-2011
20110035839Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.02-10-2011

Patent applications by Edwards Allen, O'Fallon, MO US

Edwards M. Allen, O'Fallon, MO US

Kimberly Allen, St. Louis, MO US

Patent application numberDescriptionPublished
20110129873Recombinant DNA Vectors for Expression of Human Prolactin Antagonists - Embodiments of the present invention relate generally to methods and compositions for producing human prolactin antagonists. Embodiments of the present invention also relate to various methods for improved production of human prolactin antagonists by microorganisms. These microorganisms, including 06-02-2011

Nickols G. Allen, Wentzville, MO US

Patent application numberDescriptionPublished
20090317475COMBINATION ANTITUMOR THERAPIES - Improved methods of treating cancers that are characterized by unwanted angiogenesis employ combinations of therapies designed to inhibit the VEGF mediated angiogenesis pathway with therapies designed to inhibit the bFGF-mediated angiogenesis pathway.12-24-2009

Philip H. Allen, Rolla, MO US

Patent application numberDescriptionPublished
20100012024DEVICE FOR COATING THE OUTER EDGE OF A SUBSTRATE DURING MICROELECTRONICS MANUFACTURING - New baffles and methods of using these baffles are provided. The baffles comprise a body having an edge wall configured to direct the flow of a composition against a substrate (e.g., silicon wafer) edge. The edge wall comprises a vertical surface, a curved sidewall coupled to the vertical surface, and a lip coupled to the curved sidewall. A preferred baffle is annular in shape and formed from a synthetic resinous composition. Even more preferably, the baffle is not formed of a metal. The inventive methods comprise positioning the baffle adjacent a substrate during a spin coating process so that the edge wall causes the composition to cover the edges of the substrate and preferably a portion of the back side of the substrate.01-21-2010

Ryan Allen, Imperial, MO US

Patent application numberDescriptionPublished
20110281933METHODS AND COMPOSITIONS FOR THE MANAGEMENT OF CARDIOVASCULAR DISEASE WITH OLIGONUCLEOTIDES - Disclosed are compositions and methods for treating cardiovascular disease and reducing the adverse effects induced by the administration of statins. In particular, disclosed is the use of antisense compounds to augment the expression of mirR-33 and associated genetic elements. In particular methods of the treatment of cardiovascular disease and the modulation of miR-33 levels is disclosed as well as treatment of the secondary effects including cholestasis, induced by the administration of statins is disclosed. Also disclosed is the treatment of Benign Recurrent Intrahepatic Cholestasis and reverse cholesterol transport. The disclosed methods and compositions may be practiced separately or co-administered with satins to reduce or treat statin induced secondary effects.11-17-2011

Scott I. Allen, St. Peters, MO US

Patent application numberDescriptionPublished
20100021966Method for the Preparation of Growth Hormone and Antagonist Thereof Having Lower Levels of Isoform Impurities Thereof - The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities thereof. In particular, the present invention is directed to (1) a recombinant method for preparing growth hormone with reduced isoform impurities thereof and (2) a recombinant method for preparing a growth hormone antagonist, such as pegvisomant, and its protein intermediate, also having reduced isoform impurities thereof. More specifically, the isoform impurities that are decreased by methods of the present invention are the trisulfide and des-phe isoform impurities of growth hormone and growth hormone antagonist (or its intermediate), respectively.01-28-2010