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| 20100119372 | COOLED COMPONENT WITH A FEATURED SURFACE AND RELATED MANUFACTURING METHOD - An improved type of cooled component is disclosed. The cooled components, such as turbine airfoils and combustors, have a base metal structural member, including a metal sheet or blank, with a featured surface. The features, such as fins, pins, and other protrusions, as well as divots, indentions, slots, channels, and holes, are formed by lithographic processes. The protrusions can be formed from a different material than the metal sheet or blank, preferably one with superior heat-conductive or oxidation properties. A related method of manufacturing is also disclosed. | 05-13-2010 |
| 20110059290 | BONDED ASSEMBLIES AND METHODS FOR IMPROVING BOND STRENGTH OF A JOINT - Bonded assemblies and methods for improving the bond strength of a joint are provided. The joint may be formed between bonding surfaces of a first and a second component. The first component has a bonding surface adapted to be bonded to a bonding surface of a second component. A plurality of features may be formed in at least one of the bonding surfaces. The bonding surfaces are bonded together to form the joint. A bonding material layer between the bonding surfaces may form the joint or the first and second components may be co-cured to form the joint. A chemical and mechanical bond between the bonding surfaces is formed with the plurality of features forming the mechanical bond and increasing the bond area of the chemical bond. The features may be openings and/or protrusions such as holes, slots, and bosses. | 03-10-2011 |
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| 20110105603 | COMPOSITIONS AND METHODS FOR TREATING BETA-AMYLOID RELATED DISEASES - In alternative embodiments the invention provides compositions and methods for ameliorating diseases and conditions having a beta-amyloid component, including Alzheimer's disease (AD), Vascular Dementia (VD), dementia, pre-dementia, Cognitive Dysfunction Syndrome (CDS) and loss of cognition in humans and in non-human animal. In alternative embodiment the invention provides analogs of AB-007 and its acid form E64c (loxistatin), their preparation, and pharmaceutical compositions thereof and methods of making and using same. In alternative embodiments compositions of the invention are deuterated analogs of AB-007 (or E64d) and E64c (or loxistatin). In alternative embodiments compositions of the invention are metabolically blocked forms as compared to AB-007 and loxistatin. In alternative embodiments compositions of the invention are used to ameliorate (including treat, slow, reverse or prevent) a disease or condition which can be ameliorated by partial or complete inhibition of a cysteine protease, e.g., AD, VD, CDS. The invention also provides alternative dosage forms and formulations for AB-007 and loxistatin, and for compounds of this invention, which can be used e.g., to treat AD, VD and CDS, in humans and in non-human animals. | 05-05-2011 |
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| 20080269467 | Anti-IL-17 Antibodies - Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful in particular for treating autoimmune, inflammatory, cell proliferative and developmental disorders. | 10-30-2008 |
| 20110027290 | ANTI-IL-17 ANTIBODIES - Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful in particular for treating autoimmune, inflammatory, cell proliferative and developmental disorders. | 02-03-2011 |
| 20110305711 | CGRP ANTIBODIES - The present invention provides human engineered calcitonin gene related peptide (CGRP) antibodies or antigen-binding fragment thereof. In addition, the present invention provides the use of the human engineered calcitonin gene related peptide (CGRP) antibodies or antigen-binding fragment thereof for the treatment of osteoarthritis pain. | 12-15-2011 |
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| 20100105873 | INTEGRATED APPROACH FOR GENERATING MULTIDOMAIN PROTEIN THERAPEUTICS - The invention provides method for therapeutic protein drug development that incorporates therapeutic and/or formulation and/or manufacturing considerations in the early screening process. The approach involves screening a plurality of different variants of a domain that have been determined to have the desired therapeutic property to identify one or more variants that have desired therapeutic and/or formulation characteristics, and constructing the full multidomain proteins using the identified domain variants. The present invention also provides a method for determining the shelf life of multidomain proteins in formulations. The method comprises determining a thermal denaturation and/or renaturation curve of a domain of the protein whose unfolding leads to aggregation of the protein in a solution. The method evaluates the shelf life of the multidomain protein based on the denaturation/renaturation curve. The invention also provides methods for engineering multidomain proteins to improve their therapeutic and/or formulation characteristics. | 04-29-2010 |
| 20100129379 | STABILIZED ANTIBODY FORMULATIONS AND USES THEREOF - The present invention provides methods of optimizing certain stable liquid formulations of antibodies that immunospecifically bind to antigens of interest. Such formulations are suitable for parenteral administration to a subject, and exhibit increased stability, low to undetectable levels of aggregation, low to undetectable levels of antibody fragmentation/degradation, and very little to no loss of the biological activities of the antibodies, even during long periods of storage. The methods of the invention provide formulations that offer multiple advantages over formulations produced by non-optimized methods, including less stringent or more readily available transportation and storage conditions, less frequent dosing, and/or smaller dosage amounts in the therapeutic, prophylactic and diagnostic uses of such formulations. The invention further provides methods of identifying antibodies exhibiting certain phase behaviors such that the antibodies can be formulated by the methods of the invention. Also provided are prophylactic, therapeutic, and diagnostic uses of such antibody formulations. | 05-27-2010 |
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| 20090143634 | Brachytherapy Balloon Features - A brachytherapy treatment device includes a tubular insertion member and an expandable chamber. The tubular insertion member has a proximal end and a distal end and an expandable chamber disposed on the distal end of the tubular insertion member. The expandable chamber defines an enclosed space and has inner and outer surfaces defining a wall, wherein the wall has at least first and second wall thicknesses. The expandable chamber may comprise a balloon. A main body portion of the balloon has the first wall thickness and ribs have the second wall thickness. The ribs may be disposed to be approximately parallel or perpendicular to the tubular insertion member around the circumference of the balloon. The ribs or other thickened areas provide improved symmetry, stability, and strength to an inflated balloon. Methods of forming a symmetrical radiation dosing profile are also disclosed herein. | 06-04-2009 |
| 20090156879 | Selectable Multi-Lumen Brachytherapy Devices and Methods - A brachytherapy treatment device includes at least one tubular insertion member and an expandable member. The tubular insertion member has proximal and distal ends and at least one radiation source lumen disposed along its length and branching at the distal end to provide a plurality of selectable radiation source lumens each configured to receive a radiation source. The expandable member is disposed on and surrounding the distal end of the tubular insertion member. In another embodiment, a brachytherapy treatment device may also include a plurality of selectable radiation source lumens forming an arcuate shape with respect to the longitudinal axis. Additional brachytherapy treatment devices and methods for performing brachytherapy and for forming an asymmetric radiation dosing profile are also disclosed. | 06-18-2009 |
| 20090156880 | Selectable Multi-Lumen Brachytherapy Devices and Methods - A brachytherapy treatment device includes at least one tubular insertion member and an expandable member. The tubular insertion member has proximal and distal ends and at least one radiation source lumen disposed along its length and branching at the distal end to provide a plurality of selectable radiation source lumens each configured to receive a radiation source. The expandable member is disposed on and surrounding the distal end of the tubular insertion member. In another embodiment, a brachytherapy treatment device may also include a plurality of selectable radiation source lumens forming an arcuate shape with respect to the longitudinal axis. Additional brachytherapy treatment devices and methods for performing brachytherapy and for forming an asymmetric radiation dosing profile are also disclosed. | 06-18-2009 |
| 20100217064 | PASSIVE VENT FOR BRACHYTHERAPY BALLOON CATHETERS - Embodiments of passive vent valve devices are disclosed. One of the novel aspects of the invention is its ability to transform from a packaging configuration to a use configuration. The packaging configuration allows sterilization gases to penetrate into the device through standard valve openings as well as through vented mesh openings. Passage of gas into the device, in turn, provides a means of sterilizing all surface areas in the device. Alternatively, when the valve is placed in a use configuration, the passage of gas through the vented mesh is inhibited providing a sealed environment that functions as a valve. The invention is useful in manufacturing sterile medical devices by allowing all surfaces to communicate with the sterilizing agent when the valve is in a packaging configuration or when it is in a use configuration. | 08-26-2010 |
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| 20090100873 | METHOD OF MAKING A GLASS SHEET USING CONTROLLED COOLING - Methods of drawing glass sheet via a downdraw process are provided. In certain aspects, the methods utilize rapid cooling below the root ( | 04-23-2009 |
| 20100004113 | SYNTHETIC SILICA HAVING LOW POLARIZATION-INDUCED BIREFRINGENCE, METHOD OF MAKING SAME AND LITHOGRAPHIC DEVICE COMPRISING SAME - Disclosed are synthetic silica glass having a low polarization-induced birefringence, process for making the glass and lithography system comprising optical element made of the glass. The silica glass has a polarization-induced birefringence measured at 633 nm of less than about 0.1 nm/cm when subjected to excimer laser pulses at about 193 nm having a fluence of about 40 μJ·cm | 01-07-2010 |
| 20100009154 | GLASS WITH COMPRESSIVE SURFACE FOR CONSUMER APPLICATIONS - A strengthened glass that does not exhibit frangible behavior when subjected to impact or contact forces, and a method of strengthening a glass. The glass may be strengthened by subjecting it to multiple, successive, ion exchange treatments. The multiple ion exchange treatments provide a local compressive stress maximum at a depth of the strengthened layer and a second local maximum at or near (e.g., within 10 μm) the surface of the glass. | 01-14-2010 |
| 20110265516 | COMPOSITIONAL CONTROL OF FAST RELAXATION IN DISPLAY GLASSES - Methods are provided for reducing the dimensional changes of a glass substrate during a display manufacturing process. The reductions are achieved by increasing the fast relaxation exhibited by the glass. Test methods are provided for distinguishing the effects on dimensional changes of fast relaxation versus slow relaxation. Glass substrates which exhibit reduced dimensional changes during critical thermal cycles of display manufacturing processes are also disclosed. | 11-03-2011 |
| 20120083915 | METHODS AND APPARATUS FOR PREDICTING GLASS PROPERTIES - Methods and apparatus for predicting viscosities of glass materials as a function of temperature and composition are provided. Two fitting parameters (fitting coefficients) are used for each of the viscosity-affecting components contained in the material. The parameters can accurately cover a wide range of temperatures (i.e., a wide range of viscosities) and a wide range of compositions. The viscosity predictions can be used as a guide for glass research as well as in feedback control systems for glass manufacturing processes. Methods and apparatus for predicting glass resistivity are also disclosed. | 04-05-2012 |
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| 20110251662 | Slidable Fixation Device for Securing a Medical Implant - A fixation device for retaining a leadless medical implant to tissue includes an array of elongate tines having self-expanding distal portions. The fixation tines may be advanced between an implant body and an outer jacket to deploy the tines from a delivery configuration in which the tines are constrained by the outer jacket to an expanded configuration in which the distal end portions of the tines are released from the outer jacket. The implant and fixation device are contained within a sheath for delivery to the treatment site and a pusher within the sheath advances the fixation device relative to the implant body and deploys the tines. A distal end of the implant having an electrode may form a distal tip of the delivery system, and a potential implantation site may be tested prior to deployment of the fixation device to allow for easy repositioning of the implant. | 10-13-2011 |
| 20120108922 | Implantable Medical Sensor and Fixation System - An implantable medical device, such as a sensor for monitoring a selected internally detectable physiological parameter of a patient, is attached to a fixation member that is deployable within the patient to position and orient the sensor to enable it to perform its function. The fixation member may be configured to lie in a single plane when deployed or may be tubular in shape. The attachment of the housing and fixation member includes providing the fixation member with a linear attachment strut that is non-circular in cross section and providing the housing with external members that define an elongate channel, non-circular in cross section and receptive to the attachment strut. The attachment strut can be inserted transversely into the channel and the external member can be crimped over the strut to secure the housing and fixation member together. | 05-03-2012 |
| 20120108986 | Implantable Medical Sensor and Fixation System - An implantable medical device, such as a sensor for monitoring a selected internally detectable physiological parameter of a patient, is attached to a fixation member that is deployable within the patient to position and orient the sensor to enable it to perform its function. The fixation member may be configured to lie in a single plane when deployed or may be tubular in shape. The attachment of the housing and fixation member includes providing the fixation member with a linear attachment strut that is non-circular in cross section and providing the housing with external members that define an elongate channel, non-circular in cross section and receptive to the attachment strut. The attachment strut can be inserted transversely into the channel and the external member can be crimped over the strut to secure the housing and fixation member together. | 05-03-2012 |
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| 20080280588 | User Interface Methods, Such as for Customer Self-Support on a Mobile Device - A method for providing a localized, context-sensitive user interface ( | 11-13-2008 |
| 20090124271 | MESSAGE INTERCEPT METHODS, SUCH AS FOR CUSTOMER SELF-SUPPORT ON A MOBILE DEVICE - A method for intercepting calls from a remote or mobile device for customer self-support detects when users or subscribers send messages, such as text messages. If the message contains an address that corresponds to a predetermined address (such as a customer support address), the phone may intercept the message and display a list of potential solutions to the subscriber's problems. Various other features and embodiments are disclosed. | 05-14-2009 |
| 20100056114 | LOCAL INTERCEPT METHODS, SUCH AS APPLICATIONS FOR PROVIDING CUSTOMER ASSISTANCE FOR TRAINING, INFORMATION CALLS AND DIAGNOSTICS - A method of displaying a tutorial to a user of a mobile device is disclosed. In some examples, the mobile device receives an input associated with one or more user functions of the mobile device and launches a locally based application in response to the received input. The locally based application may output instructions to the user explaining to the user how to implement the one or more user functions. | 03-04-2010 |
| 20100159902 | CALL INTERCEPT METHODS, SUCH AS FOR CUSTOMER SELF-SUPPORT ON A MOBILE DEVICE - A method for intercepting calls from a remote or mobile device for customer self-support detects when users or subscribers dial one or more predetermined numbers. If the number corresponds to one of the predetermined numbers (such as a customer support number), the phone may intercept the call and display a list of potential solutions to the subscriber's problems. Various other features and embodiments art disclosed. | 06-24-2010 |
| 20110117894 | CALL INTERCEPT METHODS, SUCH AS FOR CUSTOMER SELF-SUPPORT ON A MOBILE DEVICE - A method for intercepting calls from a remote or mobile device for customer self-support detects when users or subscribers dial one or more predetermined numbers. If the number corresponds to one of the predetermined numbers (such as a customer support number), the phone may intercept the call and display a list of potential solutions to the subscriber's problems. Various other features and embodiments art disclosed. | 05-19-2011 |
| 20120028620 | CALL INTERCEPT METHODS, SUCH AS FOR CUSTOMER SELF-SUPPORT ON A MOBILE DEVICE - A method for intercepting calls from a remote or mobile device for customer self-support detects when users or subscribers dial one or more predetermined numbers. If the number corresponds to one of the predetermined numbers (such as a customer support number), the phone may intercept the call and display a list of potential solutions to the subscriber's problems. Various other features and embodiments art disclosed. | 02-02-2012 |
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| 20090173260 | SUBSURFACE SOIL INJECTION APPARATUS WITH IMPROVED DELIVERY DEVICE - An apparatus is provided for introducing a discrete, predetermined amount of material into soil at a plurality of predetermined points in the soil which includes a container for holding the material to be introduced into the soil, and tubing in fluid communication with the container at a first end thereof. At least one electrically controlled injector is provided in fluid communication with a second end of said tubing. Also, at least one shank is provided, which includes a base, and an injector mounting member attached to a surface of the base that is adapted for detachably mounting the electrically controlled injector onto the base. In addition, a controller is provided for activating the electrically controlled injector to introduce the material into the soil. Accordingly, enhanced control of the injection of the material into soil is achieved, and maintenance can be performed easily. | 07-09-2009 |
| 20090262003 | SUBSURFACE SOIL INJECTION APPARATUS WITH IMPROVED DELIVERY DEVICE - An apparatus is provided for introducing a discrete, predetermined amount of material into soil at a plurality of predetermined points in the soil which includes a container for holding the material to be introduced into the soil, and tubing in fluid communication with the container at a first end thereof. At least one electrically controlled injector is provided in fluid communication with a second end of said tubing. Also, at least one shank is provided, which includes a base, and an injector mounting member attached to a surface of the base that is adapted for detachably mounting the electrically controlled injector onto the base. In addition, a controller is provided for activating the electrically controlled injector to introduce the material into the soil. Accordingly, enhanced control of the injection of the material into soil is achieved, and maintenance can be performed easily. | 10-22-2009 |
| 20100269742 | SUBSURFACE SOIL INJECTION APPARATUS AND METHOD - A method for the subsurface application of fertilizers, biologicals, fumigants, non-fumigant pesticides or other chemicals to soil with reduced application rates. Discrete amounts of the materials are injected into the soil at numerous sites along a path during a pass through the soil. At the injection sites, the materials form diffusion patterns which may touch or overlapping with diffusion patterns of adjacent soil injections. The application of materials to soil in this manner maintains optimum efficacy with the use of the least amount of materials necessary per acre of soil. | 10-28-2010 |
| 20110172834 | SYSTEM AND METHOD FOR CONTROLLING SUBSURFACE SOIL INJECTION APPARATUS - An apparatus is provided for introducing a discrete, predetermined amount of material into soil at a plurality of predetermined points in the soil which includes a container for holding the material to be introduced into the soil, and tubing in fluid communication with the container at a first end thereof. At least one electrically controlled injector is provided in fluid communication with a second end of said tubing. Also, at least one shank is provided, which includes a base, and an injector mounting member attached to a surface of the base that is adapted for detachably mounting the electrically controlled injector onto the base. In addition, a controller is provided for activating the electrically controlled injector to introduce the material into the soil. Accordingly, enhanced control of the injection of the material into soil is achieved, and maintenance can be performed easily. | 07-14-2011 |
| 20110174893 | DRIP IRRIGATION SYSTEMS AND METHODS - Systems and methods for injecting materials into soil within a predetermined geographical area are described. One or more tanks store chemicals and a mixing chamber in an injector mixes measured quantities of the chemicals. The mixture is introduced to a stream of water and thence to the soil. A controller monitors the flow of chemicals and the stream of water and causes the injector to release discrete predetermined amounts of the chemical mixture into the soil at a sequence of injection points. The controller can provide a pulsed signal to control the volume and rate of delivery of water. The controller may operate according to a treatment plan. | 07-21-2011 |
| 20110266303 | SYSTEM AND METHOD FOR CONTROLLING DRIP IRRIGATION - Systems and methods for injecting materials into soil within a predetermined geographical area are described. One or more tanks store chemicals and a mixing chamber in an injector mixes measured quantities of the chemicals. The mixture is introduced to a stream of water and thence to the soil. A controller monitors the flow of chemicals and the stream of water and causes the injector to release discrete predetermined amounts of the chemical mixture into the soil at a sequence of injection points. The controller can provide a pulsed signal to control the volume and rate of delivery of water. The controller may operate according to a treatment plan. | 11-03-2011 |
