| Patent application number | Description | Published |
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| 20090141959 | METHODS AND SYSTEMS FOR REMOVING AUTOFLUORESCENCE FROM IMAGES - Method and systems for removing any inherent autofluorescence associated with a biological material, comprising: acquiring a first reference image of the biological material; acquiring a first set of one or more images of the biological material using one or more filters corresponding to one or more information dyes; applying the one or more additional dyes to the biological material and then acquiring a second set of one or more images comprising a separate image of the biological material with each of the filters corresponding to the information dyes and a second reference image of the biological material; coregistering the first and second reference images; and then removing any inherent autofluorescence exhibited in the informational images acquired. | 06-04-2009 |
| 20090238432 | METHOD AND SYSTEM FOR IDENTIFYING DEFECTS IN RADIOGRAPHIC IMAGE DATA CORRESPONDING TO A SCANNED OBJECT - A method for identifying defects in radiographic image data corresponding to a scanned object is provided. The method includes acquiring radiographic image data corresponding to a scanned object. In one embodiment, the radiographic image data includes an inspection test image and a reference image corresponding to the scanned object. The method includes identifying one or more regions of interest in the reference image and aligning the inspection test image with the regions of interest identified in the reference image, to obtain a residual image. The method further includes identifying one or more defects in the inspection test image based upon the residual image and one or more defect probability values computed for one or more pixels in the residual image. | 09-24-2009 |
| 20090245598 | Methods for Assessing Molecular Expression of Subcellular Molecules - The present techniques provide fully automated methods for quantifying the location, strength and percent of expressed target molecules or other biological markers in immunohistochemically stained biological samples. The samples may be automatically segmented, for example into subcellular compartments, from images of compartmental markers. Then, the distribution of a target molecule on each of these compartments is calculated that includes the percentage and strength of expression. This is different than existing intensity or ratio based methods where abundant low expression levels are indistinguishable from scarce high expression levels. | 10-01-2009 |
| 20090245610 | Method and Apparatus for Detecting Irregularities in Tissue Microarrays - The present techniques provide systems and methods for registering images of tissue spots on a tissue microarray (TMA). In studies involving multiple biomarkers being studied on the same TMA, the TMA slide is removed from the microscope, stained, and then imaged, often multiple times. The present techniques relate to validation of the registration of the acquired images of the same TMA. An automatic approach to register the images and detect registration failures as provided herein may enhance the rapid analysis of the tissues. Artifacts such as tissue folding and tissue loss are also determined automatically. | 10-01-2009 |
| 20090245611 | Method and Apparatus for Removing Tissue Autofluorescence - Techniques for removing image autoflourescence from fluorescently stained biological images are provided herein. The techniques utilize non-negative matrix factorization that may constrain mixing coefficients to be non-negative. The probability of convergence to local minima is reduced by using smoothness constraints. The non-negative matrix factorization algorithm provides the advantage of removing both dark current and autofluorescence. | 10-01-2009 |
| 20090247416 | Method and Apparatus for Analysis of Tissue Microarrays - The present techniques include methods and systems for finding correspondences between tissue spots in tissue microarray serial sections belonging to the same recipient block. The present techniques may also be used to relate individual tissue cores to clinical information. Using either a whole slide image or the relative x-y coordinates of the tissue spots on the slide, individual tissue spots in different tissue microarrays may be linked to one another and their clinical information. | 10-01-2009 |
| 20090279772 | Method and System for Identifying Defects in NDT Image Data - An anomaly detection method includes acquiring image data corresponding to nondestructive testing (NDT) of a scanned object. The NDT image data comprises at least one inspection test image of the scanned object and multiple reference images for the scanned object. The anomaly detection method further includes generating an anomaly detection model based on a statistical analysis of one or more image features in the reference images for the scanned object and identifying one or more defects in the inspection test image, based on the anomaly detection model. | 11-12-2009 |
| 20100220910 | METHOD AND SYSTEM FOR AUTOMATED X-RAY INSPECTION OF OBJECTS - An anomaly detection method and system for comparing a scanned object to an idealized object is provided. The anomaly detection method includes generating a three-dimensional reference model of the idealized object. The anomaly detection method further includes acquiring at least one two-dimensional inspection test image of the scanned object. The anamoly detection method also includes determining a two-dimensional reference image from the three-dimensional reference model using multiple pose parameters, wherein the two-dimensional reference image corresponds to the same view of the three-dimensional reference model of the idealized object as the view of the two-dimensional inspection test image of the scanned object. The anamoly detection method further includes identifying one or more defects in the inspection test image via automated defect recognition technique. | 09-02-2010 |
| 20110026803 | METHODS AND SYSTEMS FOR DIGITALLY ENHANCING AN IMAGE OF A STAINED MATERIAL - Methods and systems for digitally enhancing an initial image of a material to which a plurality of stains were previously applied, that generally comprise: unmixing the image into a plurality of individual reconstructed images, each individual image corresponding to one of the stains; estimating a residual image corresponding to the difference between the original image and the reconstructed images; adjusting one or more components of the individual images; mixing the adjusted components using one or more estimated mixing coefficients; and adding the residual image to the mixed adjusted components to generate an enhanced image. | 02-03-2011 |
| 20110069905 | SYSTEM AND METHOD FOR DETECTING AND ELIMINATING ONE OR MORE DEFOCUSED OR LOW CONTRAST-TO-NOISE RATIO IMAGES - This invention, which provides a method for detecting a corruption in an image acquired from a biological sample, includes: providing at least one image of at least one cell; generating the image of the at least one cell over a period of time; determining if the at least one image of the at least one cell is corrupted; applying a wavelet transform, Fourier transform, or other frequency decomposing transform to the at least one image to decompose the at least one image into a plurality of sub-images, wherein the plurality of sub-images have a plurality of low frequency channels, a plurality of middle frequency channels and a plurality of high frequency channels; calculating a ratio based on an energy level of the plurality of low frequency channels and the plurality of middle frequency channels; and removing the at least one image of at least one cell if the at least one image is corrupted. | 03-24-2011 |
