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Alexey Y.

Alexey Y. Karulin, Mayfield Heights, OH US

Patent application numberDescriptionPublished
20090141132Instrumentation for image acquisition from biological and non-biological assays - Embodiments of this invention include flatbed scanners that have a surface and have a plurality of light sources. Alternatively, a single light source can be moved in two dimensions relative to an object placed on the surface of the scanner. Other embodiments include a scan head that is moveable in two dimensions relative to the flat bed of the scanner. Further embodiments include one or more polarizing filters to reduce glare and increase the quality of a captured image. Theses scanners can be used to capture images of enzyme linked immunosorbent assay (ELISA) substrates, plates having cultures thereon or other objects having irregular lower surfaces. Additional embodiments include methods for capturing images from ELISA substrates, bacterial culture plates, viral plaque assay plates and the like.06-04-2009
20100068734NANOPARTICLE AND MICROPARTICLE BASED DETECTION OF CELLULAR PRODUCTS - Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic spectral feature. In particular, devices and methods are provided for measuring secreted cellular products including cytokines. Detection substrates, include microwells having product-specific capture reagents thereon or comprising hydrophobic membranes are described having greater capability to detect products from individual cells in a mixture of heterogeneous cells. With the use of multiple detection particles, multiple cellular products can be detected in a single well. Additionally, using the inherent spectral properties of detection particles, no enzymatic reactions are needed to visualize a secreted product, thereby increasing the sensitivity, reproducibility and ease of use.03-18-2010

Patent applications by Alexey Y. Karulin, Mayfield Heights, OH US

Alexey Y. Kolyada, Newton, MA US

Patent application numberDescriptionPublished
20100003190Method for protecting renal tubular epithelial cells from radiocontrast nephropathy (RCN) - According to aspects of the invention, methods for preventing or treating kidney damage are provided. Compositions for the prevention or treatment of kidney damage are also provided. Aspects of the invention relate to methods for screening the toxicity of a radio-contrast agent. Kits for the treatment or prevention of kidney damage are also provided.01-07-2010

Alexey Y. Koposov, Los Alamos, NM US

Patent application numberDescriptionPublished
20120103404QUANTUM DOT SENSITIZED SOLAR CELL - Photoelectrochemical solar cells (PECs) consisting of a photoanode were prepared by direct deposition of independently synthesized CdSe nanocrystal quantum dots (NQDs) onto a nanocrystalline TiO05-03-2012

Alexey Y. Sharonov, Hamden, CT US

Patent application numberDescriptionPublished
20110171634METHODS AND DEVICES FOR SINGLE-MOLECULE WHOLE GENOME ANALYSIS - Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.07-14-2011
20110296903INTEGRATED ANALYSIS DEVICES AND RELATED FABRICATION METHODS AND ANALYSIS TECHNIQUES - Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.12-08-2011

Alexey Y. Sharonov, Drexel Hill, PA US

Patent application numberDescriptionPublished
20120097835DEVICES AND METHODS FOR DYNAMIC DETERMINATION OF SAMPLE POSITION AND ORIENTATION AND DYNAMIC REPOSITIONING - Provided are devices and methods for determining the spatial orientation of a target sample, which devices and methods are useful in auto focus systems. The devices and methods function by correlating (a) the location of radiation on a radiation detector of radiation reflected by the sample with (b) the position of the sample, and in some embodiments, adjusting the position of the sample, the position of an optical device, or both, in accordance with the location of radiation reflected by the sample onto the detector so as to maintain the sample in focus.04-26-2012

Alexey Y. Syschikov, Saint-Petersburg RU

Patent application numberDescriptionPublished
20090064115Enabling graphical notation for parallel programming - In one embodiment, the present invention includes a method for developing of a parallel program by specifying graphical representations for input data objects into a parallel computation code segment, specifying graphical representations for parallel program schemes, each including at least one graphical representation of an operator to perform an operation on an data object, determining if any of the parallel program schemes include at least one alternative computation, and unrolling the corresponding parallel program schemes and generating alternative parallel program scheme fragments therefrom. Other embodiments are described and claimed.03-05-2009