Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Alcino Orfeu
Alcino Orfeu De Leao E Flores, Charneca Da Caparica PT
| Patent application number | Description | Published |
|---|---|---|
| 20090068673 | UTILIZATION OF COMPATIBLE SOLUTES TO IMPROVE THE PERFORMANCE OF THE TECHNIQUES USING IMMOBILIZED BIOLOGIC MATERIALS - This invention is based upon the application of compatible solutes to immobilized biological materials or to immobilize in order to improve the technical performance using the same, namely nucleic acid and proteins or biosensors micronets. The above mentioned compatible solutes are selected from a group that includes Mannosylglycerate (MG) and its 3 derivatives manno-sylglyceramide (MGA), -mannosylglycerol (MGOH), and mannosyl-lactate (MGLac), 1,1-di-glycerol phosphate (DGP), ectoin, hydroxyectoin, and or derivatives or combinations thereof. The improved performance of the above mentioned techniques might be due to: a better state of preservation of the material to be immobilized, increasing the life expectancy of the material, and/or decreasing the storage and/or transport requirements, a more efficient and uniform deposition of the material on the support, more efficiency and/or specificity of hybridation of the marked material, all this originating an increase of the signal-to-noise ratio. | 03-12-2009 |
Alcino Orfeu De Leoão Flores, Oeiras PT
| Patent application number | Description | Published |
|---|---|---|
| 20100075335 | COLORIMETRIC METHOD AND KIT FOR THE DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES USING METAL NANOPARTICLES FUNCTIONALIZED WITH MODIFIED OLIGONUCLEOTIDES - The present invention relates to a colorimetric method for the detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences, through the aggregation of nanoparticles functionalized with modified oligonucleotides, induced by an increase of the medium's ionic strength. Another aspect of the present invention relates with the development of a kit based on the method of the present invention, allowing for a quick and easy detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences. | 03-25-2010 |
Alcino Orfeu De Leoão Flores, Oeiras PT
| Patent application number | Description | Published |
|---|---|---|
| 20100075335 | COLORIMETRIC METHOD AND KIT FOR THE DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES USING METAL NANOPARTICLES FUNCTIONALIZED WITH MODIFIED OLIGONUCLEOTIDES - The present invention relates to a colorimetric method for the detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences, through the aggregation of nanoparticles functionalized with modified oligonucleotides, induced by an increase of the medium's ionic strength. Another aspect of the present invention relates with the development of a kit based on the method of the present invention, allowing for a quick and easy detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences. | 03-25-2010 |