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| 20100095868 | PEARLESCENT PIGMENTS WITH A CROSS-LINKABLE BINDING AGENT COATING, COATING COMPOSITION, METHOD FOR PRODUCING THE COATED PERLESCENT PIGMENTS AND USE THEREOF - The invention relates to coated pearlescent pigments, whereby the coating covers the pearlescent pigments and comprises uncured, however, chemically cross-linkable and/or oligomeric and/or polymeric binding agents that can be cross-linked by heat, IR radiation, UV radiation and/or electron rays. The invention also relates to a method for producing the coated pearlescent pigments and to the use thereof. The invention additionally relates to a coating composition and to a coated article. | 04-22-2010 |
| 20110207833 | METALLIC PIGMENT PREPARATION IN COMPACTED FORM, METHOD FOR PRODUCING THE SAME AND USE THEREOF - A pigment preparation with metallic effect pigments in compacted form, the pigment preparation including the following components: a) 60%-95% by weight of at least one metallic effect pigment which has at least one low-refractive-index layer (low-index layer) on the metallic core of the metallic effect pigment, the low-index layer comprising or consisting of at least one inorganic component, b) 0.5%-40% by weight of a binder which is free from styrene groups, has an acid number of 150-500 mg KOH/g binder, and a melting point or melting range which lies in the range of 120-200° C., c) a residual moisture content in the range of 0%-15% by weight of at least one of water, organic solvent and a solvent mixture and d) optionally neutralizing agent(s). The disclosure further relates to a method for producing the pigment preparation and also to the use thereof. | 08-25-2011 |
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| 20090017201 | METHOD FOR COATING OR DECOATING A COMPONENT - The invention relates to a method for coating or decoating a component, in particular a gas turbine component, wherein, in order to regionally or partially coat or decoat a component, the component is preferably completely covered with a covering medium, and wherein the covering medium is removed from only those surface regions of the component in which the coating or decoating of the component is supposed to take place, so that a surface region of the component which is not to be coated or decoated is covered by the covering medium. According to the invention, the covering medium is removed by means of water jet machining. | 01-15-2009 |
| 20090186157 | Method for at least selectively removing a first layer from an engine component - A method for selectively removing a first layer from an engine component including the first layer, a base material and a second layer forming a bond connecting the first layer to the base material is provided. The method includes applying a salt melt to at least one section of the engine component including at least one portion of the second layer so the bond formed by the second layer between the base material and the first layer is at least weakened. | 07-23-2009 |
| 20100108538 | METHOD FOR STRIPPING A COMPONENT - A method for stripping a component, in particular a gas turbine component, to completely or partially remove a multilayer or sandwich antiwear coating from the surface of the component, the antiwear coating including at least one relatively hard ceramic layer and at least one relatively soft metallic layer is disclosed. According to the present invention, in order to remove the multilayer or sandwich antiwear coating, the component is placed in a bath of an alkaline electrolyte, the component placed in the electrolyte being stripped at a current density of between 1 A/dm | 05-06-2010 |
| 20100263694 | DECOATING DEVICE FOR AXIALLY SYMMETRIC COMPONENTS, PARTICULARLY FROM AIRCRAFT ENGINES - A decoating device for axially symmetric components, particularly from aircraft engines is provided, the decoating process being carried out through the use of a decoating fluid-which is brought on a localized basis into contact with the component to be decoated, a receptacle for holding the decoating fluid being provided that rotates at least about one axis of rotation, and the decoating fluid surface forming a rotation paraboloid in response to the rotation, the component(s) to be decoated on a localized basis being accommodated in the receptacle and being dipped on the radially outer side into the decoating fluid. A decoating device is thereby devised which makes it possible for radially symmetric components to be decoated in the radially outer region in a simple process. | 10-21-2010 |
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| 20080269300 | Substituted Phenylaminothiazoles and Use Thereof - The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders. | 10-30-2008 |
| 20100022537 | I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE - This invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development. | 01-28-2010 |
| 20100104501 | PRSS23 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET - The invention provides PRSS23, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. | 04-29-2010 |
| 20100184788 | HETEROCYCLIC DERIVATIVES - The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development. | 07-22-2010 |
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| 20110009529 | Copolymer Having Polyether Side Chains And Dicarboxylic Acid Derivative Components - The invention relates to a copolymer which can be used as a superplasticizer for hydraulic binders and comprises 30 to 47 mol % of a (meth)allyl alcohol polyether derivative structural unit and 53 to 70 mol % of a maleic acid derivative structural unit. | 01-13-2011 |
| 20110009575 | Semi Continuous Operational Method For Producing Copolymers - The invention relates to a process for the preparation of a copolymer in a semicontinuous mode of operation in a polymerization apparatus containing a polymerization reactor connected to a metering device, in each case acid monomer being initially introduced into the metering device and polyether macromonomer and water into the polymerization reactor, acid monomer being metered from the metering device into the polymerization reactor, free radical polymerization initiator being passed into the polymerization reactor before and/or during the metering of the acid monomer into the polymerization reactor, so that an aqueous medium forms in the polymerization reactor, in which aqueous medium acid monomer and polyether macromonomer are reacted by free radical polymerization with formation of the copolymer, at least 70 mol % of the polyether macromonomer initially introduced into the polymerization reactor being converted by the free radical polymerization, the conversion of the acid monomer giving rise in the copolymer to an acid structural until which reduces the pH of the aqueous medium to a lesser extent than the acid monomer as such, the metering of the acid monomer into the polymerization reactor being effected in such a way that first a polymerization pH is established in the aqueous medium and then, until the conversion of 70 mol % of the polyether macromonomer initially introduced into the polymerization reactor, acid monomer is passed into the polymerization reactor in an amount per unit time such that the pH in the aqueous medium deviates by not more than ±0.3 from the initially established polymerization pH. | 01-13-2011 |
| 20110034592 | Aqueous Solution Containing Copolymers with Polyether Side Chains - The invention relates to a process for the preparation of an aqueous solution comprising 30 to 95% by weight of water and 5 to 70% by weight of a copolymer dissolved in the water by free radical solution polymerizations of an isoprenol polyether derivative with an acrylic acid derivative, so that the copolymer has 20 to 45 mol % of an isoprenol polyether derivative structural unit and 55 to 80 mol % of an acrylic acid derivative structural unit. The aqueous solution is suitable as a superplasticizer for hydraulic binders. | 02-10-2011 |
| 20110034625 | METHOD FOR INITIATING RADICAL POLYMERIZATIONS - The invention relates to a process for the preparation of polymers by free radical polymerization of monomers in the presence of water, electrochemically produced free radicals being used for initiating the free radical polymerization. | 02-10-2011 |
| 20110054083 | Copolymer Comprising Polyether Side Chains and Hydroxyalkyl and Acid Structural Units - The invention relates to a copolymer which is suitable as a superplasticizer for hydraulic binders and comprises 5 to 55 mol % of an isoprenol polyether derivative structural unit, 2 to 90 mol % of an acrylic acid derivative structural unit and 2 to 90 mol % of a hydroxyalkyl acrylate structural unit. | 03-03-2011 |
| 20110203486 | Hardening Accelerator Composition Containing Dispersants - A process for the preparation of a hardening accelerator composition by reaction of a water-soluble calcium compound with a water-soluble silicate compound, said reaction being effected in the presence of a water-soluble dispersant having at least one polyalkyleneglycol structural unit with a functional group at one end of the polyalkyleneglycol, being able to interact as an anchor group with the surface of cement particles, the hardening accelerator composition and its use. | 08-25-2011 |
| 20110269875 | Plasticizer-Containing Hardening Accelerator Composition - The invention concerns a process for the preparation of a hardening accelerator composition by reaction of a water-soluble calcium compound with a water-soluble silicate compound and a process for the preparation of a hardening accelerator composition by reaction of a calcium compound with a silicon dioxide containing component under alkaline conditions, in both cases the reaction of the water-soluble calcium compound with the water-soluble silicate compound being carried out in the presence of an aqueous solution which contains a water-soluble comb polymer suitable as a plasticizer for hydraulic binders. The invention concerns also a composition of calcium silicate hydrate and comb polymer, its use as hardening accelerator and for the reduction of the permeability of hardened compositions. | 11-03-2011 |
| 20110294923 | Polymerization Mixture That Can Be Produced Without Water - The invention relates to a process for the preparation of a polymerization mixture suitable as a dispersant and comprising a copolymer. In the process, a vinyloxyalkylpolyether derivative is reacted with an acid monomer derivative with formation of the copolymer in the presence of a free radical polymerization initiator by free radical polymerization, the free radical polymerization taking place in a medium which contains less than 25% by weight of water and in totality more than 60% by weight of copolymer, vinyloxyalkylpolyether derivative and acid monomer derivative. | 12-01-2011 |
| 20120004350 | Semi Continuously Operated Method for Producing Copolymers - The invention relates to a process for the preparation of a copolymer in semicontinuous operation in a polymerization apparatus, comprising a polymerization reactor connected to a metering device, in each case acid monomer being initially taken in the metering device and polyether macromonomer, acid monomer and water in the polymerization reactor, acid monomer being metered from the metering device into the polymerization reactor, free radical polymerization initiator being passed into the polymerization reactor before and/or during the metering of the acid monomer into the polymerization reactor so that an aqueous medium in which acid monomer and polyether macromonomer are reacted with formation of the copolymer by free radical polymerization forms in the polymerization reactor, the molar ratio of acid monomer used altogether to polyether macromonomer used altogether being 20:1 to 1:1, the molar ratio of acid monomer initially taken in the polymerization reactor to the acid monomer metered into the polymerization reactor being 10:1 to 1:10 and the metering of the acid monomer being effected with the proviso that at least 70 mol % of the acid monomer metered in altogether are metered in the course of 5 to 19 minutes at a metering rate that is constant or varies to a limited extent. | 01-05-2012 |
| 20120041106 | Dispersing Agent Containing Copolymer Mixture - The invention relates to a polymer composition containing 5 to 95% by weight of a copolymer H and 2 to 60% by weight of a copolymer K, the copolymers H and K each having polyether macromonomer structural units and acid monomer structural units, which are present in the copolymers H and K in each case in a molar ratio of 1:20 to 1:1, and at least 20 mol % of all structural units of the copolymer H and at least 25 mol % of all structural units of the copolymer K being present in each case in the form of acid monomer structural units, the polyether macromonomer structural units of the copolymer H having side chains containing in each case at least 5 ether oxygen atoms, the number of ether oxygen atoms per side chain of the polyether macromonomer structural units of the copolymer H varying in such a way that the corresponding frequency distribution diagram, in which the number of ether oxygen atoms per side chain of a polyether macromonomer structural unit is plotted along the abscissa and the associated frequency for the copolymer H is plotted along the ordinate, contains at least 2 maxima. | 02-16-2012 |
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| 20090024010 | Hand-held analysis device having different setting modes - A handheld analysis device for examining a sample of body fluid, such as blood to analyze blood glucose, has a setting mode for changing various device settings to improve the changing of device settings. The handheld analysis device comprises a measurement unit, a microprocessor, a segment display, and an operating element. When the operating element is actuated, the device is placed in a selection mode and further actuation of the operating element, then in one of several setting modes, the user can efficiently change device settings by inputting data and/or control commands. | 01-22-2009 |
| 20090298182 | HANDHELD ANALYZER FOR TESTING A SAMPLE - The invention relates to a handheld analyzer for testing a sample, in particular of a biological fluid, for a medically significant component. It comprises a test unit, which detects the correct positioning of an analytical consumable means in a conveyance pathway. According to this invention, the test unit has both an electric switch component which mechanically senses the positioning of the analytical consumable means and an optical sensor unit which optically senses the positioning of the analytical consumable means on the conveyance pathway. The handheld analyzer is controlled as a function of a comparison of the signals of the electric switch component and the optical sensor unit. It is possible in this way to reduce malfunctions or operating errors associated therewith. | 12-03-2009 |
| 20110281342 | HAND-HELD DEVICE FOR MEASURING AN ANALYTE CONCENTRATION IN A SAMPLE OF A BODY LIQUID - A hand-held device for measuring an analyte concentration in a sample of a body liquid includes a display means for displaying measured values; a measured-value storage for storing measured values; a measuring unit for generating measured values through measurements of the analyte concentration; a clock; a control unit for generating measured value datasets, each containing a measured value supplied by the measuring unit as well as the date and hour of the measurement by which the measured value was obtained, and for writing them into the measured-value storage; and operating elements that can be actuated by the user to set the clock, in which case the control unit will generate a time-correction dataset indicating the amount and direction of the setting effected. The control unit writes time-correction datasets into the measured-value storage so that a chronologically ordered sequence is generated containing time-correction datasets and measured value datasets. | 11-17-2011 |
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| 20080305335 | CORE-SHELL STRUCTURED SILICONE RUBBER GRAFT POLYMERS, IMPACT-RESISTANT MODIFIED MOLDING COMPOUNDS AND MOLDED BODIES AND METHOD FOR PRODUCING THE SAME - The invention relates to core-shell structured silicone rubber graft polymers that comprise a core a) from a silicium-organic polymer that corresponds to the general formula (R2SiO2/2)x.(RSiO3/2)y.(SiO4/2)z, wherein x=0 to 99.5 mole %, y=0.5 to 100 mole %, z=0 to 50 mole %, wherein R is the same or different and represents alkyl or alkenyl groups having 1 to 6 C atoms, aryl groups or substituted hydrocarbon groups and at last one shell c) from an organic polymer. The silicone rubber graft copolymers are obtained by producing the organic shell c) by radical polymerization at a temperature of not more than 65° C. and adding the initiator in at least two portions to the reaction vessel, with a further addition at least 2 minutes after start of the polymerization. | 12-11-2008 |
| 20090215962 | MULTILAYERED FILM MADE OF (METH)ACRYLATE COPOLYMER AND POLYCARBONATE - The invention relates to a multilayer film encompassing at least one upper layer a) and one middle layer b) composed of (meth)acrylate copolymers, and also a backing layer c) composed of polycarbonate, where the upper layer a) comprises a light stabilizer and is composed of a (meth)acrylate copolymer which can form semicompatible mixtures with the polycarbonate of the backing layer c), where a test specimen produced from a mixture composed of 20% by weight of (meth)acrylate copolymer and 80% by weight of polycarbonate has a tensile strain at break of at least 75% (ISO 527-2) at 23° C., the middle layer b) comprises a dye and, where appropriate, a light stabilizer, and is composed of an identical or different (meth)acrylate copolymer which can form semicompatible mixtures with the polycarbonate of the backing layer c), where a test specimen produced from a mixture composed of 20% by weight of (meth)acrylate copolymer and 80% by weight of polycarbonate has a tensile strain at break of at least 75% (ISO 527-2) at 23° C., and the backing layer c) is composed of polycarbonate which can, where appropriate, comprise up to 30% by weight of the material of the layers a) and b). The invention also relates to the production and uses of the multilayer film, and also to semicompatible polymer mixtures composed of (meth)acrylate copolymers and polycarbonate. | 08-27-2009 |
| 20100213636 | METHOD FOR THE PRODUCTION OF COATED MOLDINGS - The present invention relates to a process for the production of coated mouldings, by injecting a moulding composition into an injection mould and cooling the composition to obtain a moulding, and altering the injection mould in such a way as to produce an intermediate space between a surface to be coated of the moulding and the inner surface of the injection mould, and using injection moulding to charge a reactive mixture to the resultant intermediate space, where the temperature of at least a portion of the injection mould is increased for the curing of the reactive mixture. | 08-26-2010 |
| 20100272960 | MOLDED BODY HAVING MATT AND STRUCTURED SURFACE PROPERTIES - Composition for the production of mouldings having a matt and structured surface character, comprising a polymer matrix and crosslinked polymer particles, the polymer matrix comprising at least one acrylic polymer and the composition containing
| 10-28-2010 |
| 20110015317 | POLY(METH)ACRYLIMIDE HAVING IMPROVED OPTICAL AND COLOR PROPERTIES, PARTICULARLY UNDER THERMAL LOAD - Process for preparing moulding materials MM with improved optical and colour properties, consisting of a polymer PM which contains units of the formula I | 01-20-2011 |
| 20110230610 | POLYMER BLEND FOR MATTE INJECTION MOULDED PARTS - The invention relates to a polymer mixture, comprising
| 09-22-2011 |
| 20120015141 | MOULDING COMPOUND FOR MOULDINGS WITH HIGH WEATHER RESISTANCE - A moulding compound comprises a copolymer (I)a), produced by polymerisation of 90-100% by weight methylmethacrylate, styrene and malic acid anhydride, and optionally 0-10% by weight additional monomers which can be copolymerised with methylmethacrylate, a (co)polymer (II)b), produced by polymerisation of 80-100% by weight methylmethacrylate and optionally 0-20% by weight additional monomers which can be copolymerised with methylmethacrylate, and has a solution viscosity in chloroform at 25° C. (ISO 1628 Part 6) of 50 to 55 ml/g, as well as c) optional conventional additives, auxiliary agents and/or fillers. The moulding compound is characterised in that the copolymer (I) has a solution viscosity in chloroform at 25° C. (ISO 1628 Part) of 55 ml/g or less. Also disclosed are mouldings produced by thermoplastic processing of the moulding compound and their uses. | 01-19-2012 |
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| 20080283026 | FUEL SYSTEM, ESPECIALLY OF THE COMMON RAIL TYPE, FOR AN INTERNAL COMBUSTION ENGINE - A fuel system for an internal combustion engine includes at least one first fuel pump and a pressure region into which the fuel pump pumps and which communicates with an elastic volume reservoir. The elastic volume reservoir has a characteristic pressure/volume curve, which is defined by at least two points. It is proposed that a first point is defined by a first volume at a first pressure that is somewhat greater than a vapor pressure of the fuel at ambient temperature, and that a second point is defined by a second volume and a second pressure in the pressure region that corresponds to a maximum pressure; the difference between the first and second volumes corresponds at least approximately and at least to a value by which the volume of the fuel in the pressure region decreases upon cooling down from a maximum temperature to ambient temperature. | 11-20-2008 |
| 20100126474 | HIGH-PRESSURE FUEL PUMP FOR A FUEL INJECTION SYSTEM OF AN INTERNAL COMBUSTION ENGINE - The invention relates to a high pressure fuel pump for a fuel injection system of an internal combustion engine, having a pump housing in which is formed a working space, into which fuel can be supplied from a low pressure region of the radial piston pump, the working space being delimited by a pump piston which can be driven, in order to pressurize the fuel, by an external drive, in particular by a camshaft of an internal combustion engine, wherein in order to meter the fuel quantity supplied to the working space, a throttle device having a variable throttle action is arranged on or in the pump housing. | 05-27-2010 |
| 20100282214 | METHOD FOR CONTROLLING A FUEL INJECTION SYSTEM OF AN INTERNAL COMBUSTION ENGINE - In a method for controlling a fuel injection system ( | 11-11-2010 |
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| 20090302267 | Inorganic Compounds - The invention relates to a chemical compound of the formula Ni | 12-10-2009 |
| 20090314985 | PULVERULENT COMPOUNDS, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF IN LITHIUM SECONDARY BATTERIES - The present invention relates to pulverulent compounds of the formula Li | 12-24-2009 |
| 20100059707 | Mixed metal hydroxides and their preparation and use - The present invention relates to a particulate mixed metal hydroxide that includes nickel, cobalt and aluminium. The powder particles have a core of nickel/cobalt hydroxide, and a surface that is coated with amorphous aluminium hydroxide. A process for the continuous preparation of such mixed metal hydroxides is also described. The process includes precipitating aluminium hydroxide in the presence of a nickel/cobalt mixed hydroxide in a tube reactor. The mixed metal hydroxides of the present invention may be used to prepare active materials for positive electrodes of a secondary battery. | 03-11-2010 |
| 20110300470 | DEVICE AND METHOD FOR THE PRODUCTION OF COMPOUNDS BY PRECIPITATION - The invention relates to a device and a method for the production of compounds by precipitation of solids from solutions, the physical and chemical properties of the solid particles formed on precipitation being flexible and can be independently fixable. Custom products can thus be produced with very high space-time yields and a particulate nickel/cobalt mixed hydroxide of formula Ni | 12-08-2011 |
| 20120045647 | TUNGSTIC ACID POWDER CONSISTING OF SPHERICAL TUNGSTEN PARTICLES AND METHOD FOR PRODUCING SAME - Process for the production of a powdered spherical tungstic acid by acidification of an aqueous alkaline tungstate solution with mineral acid at elevated temperature, preferably in a continuous stirred tank or a cascade of at least 2 continuous stirred tanks, and tungstic acid obtainable in this way, which is characterised by a high bulk density and spherical morphology. | 02-23-2012 |
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| 20110160642 | PEGYLATED LIPOSOMAL FORMULATIONS FOR PHOTODYNAMIC TREATMENT OF INFLAMMATORY DISEASES - A PDT treatment system designed to treat all types of human inflammatory disorders. A suitable drug delivery system is developed to target proliferating cells, at inflamed sites, populated with macrophages and other inflammatory mediators. The hydrophobic photosensitizer is loaded into the liposomal bilayer formed of synthetic phospholipids; at least one of the synthetic phospholipids is conjugated to polyethylene glycol (PEG) molecules, to prevent accumulation in the liver and spleen. Further, (PEG) formulated photosensitizer increases the circulatory half-life of the drug, enhances solubility, and modifies pharmacokinetic and pharmacodynamic properties. The formulation, thus, leads to a higher amount of delivered drug to the diseased target synovial tissue, increasing clinical effectiveness. In one embodiment, pegylated liposomes loaded with mTHPC are administered to diseased synovial joints, followed by light irradiation. Activated photosensitizer induces cytotoxic effect in the diseased synovial cells, thus preventing further inflammation and joint erosion and minimizing joint damage. | 06-30-2011 |
| 20110178580 | ENHANCED ANTI-MICROBIAL PDT - Present invention provides enhanced methods and improved devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids. In preferred embodiments, present invention provides an antimicrobial PDT treatment that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity includes the steps of administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Preferred device embodiments comprise guiding channels and at least one electromagnetic radiation source, arranged separately or in sequence. Preferably, laser device or LED-panels are used to deliver electromagnetic radiation to activate the photosensitizer. When used with preferred photosensitizer composition based on Safranin O, preferred laser radiation wavelength is in the range of 500-580 nm. Additionally, present invention diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it. | 07-21-2011 |
| 20110257586 | CALCIUMPHOSPHATE-BASED NANOPARTICLES AS CARRIER-SYSTEMS FOR PHOTODYNAMIC THERAPY - The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic photosensitizer, nanoparticulate calcium phosphate and in certain cases auxiliary reagents such as stabilizers. The calcium phosphate-based nanoparticle formulations of the present invention provide excellent storage stability and therapeutically effective amounts of photosensitizer for intravenous or topical administration. In a preferred embodiment, tetrapyrrole derivatives such as porphyrins, chlorins and bacteriochlorins, are the preferred hydrophobic photosensitizers to be formulated in calcium phosphate nanoparticle formulations for photodynamic tumor therapy. Additionally, 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (pTPPP) is a preferred hydrophilic photosensitizer for photodynamic tumor therapy. In another preferred embodiment, hydrophilic cationic and anionic photosensitizers, especially those of the phenazinium, phenothiazinium and xanthenes series have been found to inactive pathogen bacteria and are the preferred photosensitizers to be formulated in calcium phosphate nanoparticle formulations for antibacterial photodynamic therapy. In another embodiment, photosensitizing nanoparticle formulations are useful to locate cells, tissues or bacteria by using fluorescence imaging methods. | 10-20-2011 |
| 20110275686 | NANOPARTICLE CARRIER SYSTEMS BASED ON POLY(DL-LACTIC-CO-GLYCOLIC ACID) (PLGA) FOR PHOTODYNAMIC THERAPY (PDT) - Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for clinical use in photodynamic therapy comprising a hydrophobic photosensitizer, poly(lactic-co-glycolic) acid and stabilizing agents are provided. These nanoparticulate pharmaceutical formulations provide therapeutically effective amounts of photosensitizer for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers, whose efficacy and safety are enhanced by such nanoparticulate formulations. It also teaches the method of preparing PLGA-based nanoparticles under sterile conditions. In one of the preferred embodiments of the present invention PLGA-based nanoparticles have a mean particle size less than 500 nm and the photosensitizer is temoporfin, 5,10,15,20-tetrakis(3-hydroxyphenyl)-chlorin (mTHPC). In another embodiment, the photosensitizer 2,3-dihydroxy-5,10,15,20-tetrakis(3-hydroxyphenyl)-chlorin (mTHPD-OH) is formulated as a nanoparticle for parenteral administration. Yet, in another embodiment preferred photosensitizer is 5,10,15,20-tetrakis(3-hydroxyphenyl)-porphyrin (mTHPP). The formulations can be used for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells. | 11-10-2011 |
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| 20080274169 | Photosensitizer formulations for topical applications - Highly flexible penetrating liposomal carrier systems are formulated with enhanced skin penetration properties. These specialized formulations of highly flexible penetrating liposomal delivery systems comprise one or more phospholipids, lysophosphatides and hydrophobic photosensitizer. This new formulations can squeeze liposomal particles through intercellular regions of stratum corneum as intact structures, and, in this way, deliver encapsulated photosensitizer to the epidermis, dermis, hypodermis and surroundings. The penetrating liposomal formulation provides therapeutically effective amounts of the hydrophobic photosensitizer through topical application with better skin penetration thus improving drug targeting and the efficacy of photodynamic therapy (PDT). | 11-06-2008 |
| 20080279921 | Gel-formulations of hydrophobic photosensitizers for mucosal applications - The present invention relates to improved methods of formulations of hydrophobic photosensitizers, and their precursors, for mucosal administration. The formulation of the invention comprises of hydrophobic photosensitizers which have been incorporated into suitably sized liposomes. Additionally, these formulations include the incorporation of PS-loaded liposomes into a copolymer matrix. The liposome of the present invention allows the hydrophobic photosensitizers to be incorporated into the thermogel matrix and thus promoting intimate contact between the formulation and the mucosal layer for enhanced drug absorption. | 11-13-2008 |
| 20090081281 | Photosensitizer Formulation for Topical Applications - Highly flexible penetrating liposomal carrier systems are formulated with enhanced skin penetration properties. These specialized formulations of highly flexible penetrating liposomal delivery systems comprise one or more phospholipids, lysophosphatides and hydrophobic photosensitizer. This new formulations can squeeze liposomal particles through intercellular regions of stratum corneum as intact structures, and, in this way, deliver encapsulated photosensitizer to the epidermis, dermis, hypodermis and surroundings. The penetrating liposomal formulation provides therapeutically effective amounts of the hydrophobic photosensitizer through topical application with better skin penetration thus improving drug targeting and the efficacy of photodynamic therapy (PDT). | 03-26-2009 |
| 20090169611 | Gel-Formulations of Hydrophobic Photosensitizers for Mucosal Applications - The present invention relates to improved methods of formulations of hydrophobic photosensitizers, and their precursors, for mucosal administration. The formulation of the invention comprises of hydrophobic photosensitizers which have been incorporated into suitably sized liposomes. Additionally, these formulations include the incorporation of PS-loaded liposomes into a copolymer matrix. The liposome of the present invention allows the hydrophobic photosensitizers to be incorporated into the thermogel matrix and thus promoting intimate contact between the formulation and the mucosal layer for enhanced drug absorption. | 07-02-2009 |
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| 20100247626 | PEGYLATED COMPOUNDS FOR AGE-RELATED MACULAR DEGENERATION - A special photosensitizer formulation and Photodynamic Therapy method for treating choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) is provided. CNV is a major cause for vision loss in elderly patients. A special drug delivery formulation is used to encapsulate the hydrophobic photosensitizer, preferably a pegylated liposome. This improves the solubility and therapeutic index of the photosensitizers. In one preferred embodiment, a pegylated photoactive agent remains confined in the intravascular compartment of neovasculature for a longer duration. Thus efficient elimination of neovascular proliferation and minimal damage to extravascular tissue and normal vessels is ensured. In this method, a hydrophobic photosensitizer, that is able to photochemically destroy neovessels, is injected into the patient. CNV irradiation with a non-thermal laser follows after a predefined time interval. The excited photosensitizer photocoagulates newly formed blood vessels thereby improving the vision and preventing further loss of vision. | 09-30-2010 |
| 20110034854 | PDT ASSISTED VISION CORRECTION AND SCAR PREVENTION - A method and formulation are disclosed for improving the results of corneal refractive surgery, and generally reducing post-operative scarring and scarring arising from other traumas. In the vision examples, after completion of a procedure, including Photorefractive Keratotomy (PRK) or Laser-In-Situ Keratomileusis (LASIK), a photosensitizer or photosensitizer precursor is applied to the treatment site. After allowing sufficient time for the photosensitizers to accumulate among proliferating cells that occur as a result of ablation, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is thus activated to destroy only those proliferating cells. In this way, proliferating tissue is eliminated and the cornea maintains the shape created during the surgery. As a result, instances of regression and the need for follow-up treatments, is minimized. This method is also useful for preventing post-surgical scarring that can lead to vision problems such as corneal haze. Likewise the method and formulations, presented here, are suitable for reducing post-operative scarring, and trauma cased scarring in general. For such scars, a photosensitizer or photosensitizer precursor is topically applied to the treatment site. After allowing sufficient time for the photosensitizers to attach to proliferating cells, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is activated to destroy only those proliferating cells. | 02-10-2011 |
