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| 20080226729 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES - The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided. | 09-18-2008 |
| 20090270792 | MICROPROTRUSION ARRAYS AND METHODS FOR USING SAME TO DELIVER SUBSTANCES INTO TISSUE - Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped. | 10-29-2009 |
| 20090299274 | Method and Device for the Delivery of a Substance - An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin. | 12-03-2009 |
| 20090304744 | METHODS OF ENHANCING IMMUNE RESPONSE IN THE INTRADERMAL COMPARTMENT AND COMPOUNDS USEFUL THEREOF - The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations. | 12-10-2009 |
| 20110159047 | STABLE POWDER FORMULATIONS OF ALUM-ADSORBED VACCINES - The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided. | 06-30-2011 |
| 20120041394 | OPTIMIZED INTRACRANIAL CATHETERS FOR CONVECTION-ENHANCED DELIVERY OF THERAPEUTICS - A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter. | 02-16-2012 |
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| 20080198358 | FIBER OPTIC DEVICE FOR SENSING ANALYTES - A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations. | 08-21-2008 |
| 20080275318 | BIOSENSORS FOR MEASURING ANALYTES IN THE INTERSTITIAL FLUID - The invention relates to methods and devices for measuring blood glucose levels in a subject, where the methods and devices are designed for exposing a sensing mechanism to interstitial fluid in the subject. | 11-06-2008 |
| 20090232700 | Sterilization of Biosensors - The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor. | 09-17-2009 |
| 20110184259 | Fiber Optic Device for Sensing Analytes and Method of Making Same - A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel. | 07-28-2011 |
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| 20110133910 | SYSTEM AND METHOD FOR TRANSMITTING HAPTIC DATA IN CONJUNCTION WITH MEDIA DATA - Methods, systems, and apparatus for generating sensations in response to haptic data. A sensation output device can include a processor adapted to generate one or more control signals corresponding to a haptic command, an actuator adapted to output a force to a drive mechanism in response to one or more control signals received from the processor, an opening through which a portion of a user's body can be inserted, and an interface surface coupled to the drive mechanism, the interface surface configured to at least partially contact the inserted portion of the user's body. Further, the interface surface can be a compliant belt having surface features that is coupled with a carrier belt that is in contact with the drive mechanism. Additionally, the sensation output device can include a memory storing an algorithm including one or more haptic commands, which can be executed by the processor. | 06-09-2011 |
| 20110265806 | ELECTRONIC SMOKING DEVICE - An electronic smoking device includes a first sensor for detecting a user's action for smoking, an air inlet, an air flow path extending from the air inlet, a liquid compartment storing a smoking liquid, a dispensing control device configured to selectively dispense the smoking liquid from the liquid compartment, a vaporizing compartment connected to the liquid compartment and the air flow path, a heater located at the vaporizing compartment, a controller configured to activate the heater to vaporize the smoking liquid dispensed from the liquid compartment when the user's action for smoking is detected by the first sensor, and a smoke outlet connected to the vaporizing compartment, wherein an amount of the smoking liquid dispensed by the dispensing control device is responsive to an amount of air flowing in the vaporizing compartment. | 11-03-2011 |
