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Alan M.
Alan M. Ezrin, Vancouver CA
| Patent application number | Description | Published |
|---|---|---|
| 20100120890 | ION CHANNEL MODULATING ACTIVITY I - Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes. | 05-13-2010 |
Alan M. Ezrin, Miami, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090041841 | CONTROLLED RELEASE TABLET FORMULATIONS FOR THE PREVENTION OF ARRHYTHMIAS - Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation are disclosed. Controlled release tablet formulations comprising a therapeutically effective amount of an ion channel modulating compound, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients suitable for controlled release formulations are disclosed. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. | 02-12-2009 |
| 20090175821 | Modified therapeutic peptides with extended half-lives in vivo - A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity. | 07-09-2009 |
| 20090270478 | ION CHANNEL MODULATING ACTIVITY II - Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g., atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes. | 10-29-2009 |
| 20100273724 | PEGYLATED ION CHANNEL MODULATING COMPOUNDS - This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed | 10-28-2010 |
| 20110118329 | USES OF ION CHANNEL MODULATING COMPOUNDS - Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. | 05-19-2011 |
Alan M. Grossmeier, Colfax, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20100324854 | MEMORY-DAUGHTER-CARD-TESTING METHOD AND APPARATUS - A memory daughter card (MDC) is described, having a very high-speed serial interface and an on-card MDC test engine that allows one MDC to be directly connected to another MDC for testing purposes. In some embodiments, a control interface allows the test engine to be programmed and controlled by a test controller on a test fixture that allows simultaneous testing of a single MDC or one or more pairs of MDCs, one MDC in a pair (e.g., the “golden” MDC) testing the other MDC of that pair. Other methods are also described, wherein one MDC executes a series of reads and writes and other commands to another MDC to test at least some of the other card's functions, or wherein one port executes a series of test commands to another port on the same MDC to test at least some of the card's functions. | 12-23-2010 |
Alan M. Horsager, Los Angeles, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080294223 | Fitting a Neural Prosthesis Using Impedance and Electrode Height - The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement. | 11-27-2008 |
| 20090312818 | Visual Prosthesis for Control of Spatiotemporal Interactions - In a visual prosthesis or other neural stimulator it is advantageous to provide non-overlapping pulses in order to provide independent control of brightness from different electrodes. Non-overlapping pulses on geographically close electrodes avoid electric-field interaction which leads to brightness summation or changes in the shape and area of percepts. It is advantageous to apply pulses to nearby electrodes in a way that the currents do not overlap in time at all. The new finding is that even a small amount of separation results in a significant improvement as small as (ie. 0.225 msec). ‘Nearby’ is defined as within a few millimeters of each other. Another new finding is that there is some additional benefit of separating the pulses in time even further. In particular, some experiments showed a benefit of separating them more than 1.8 msec. Another experiment showed a benefit of separating them greater than 3 msec. But, there is probably no benefit to separating them more than 5 msec. The same parameters that provide independent control of brightness also produce spatial patterns that the subjects' report as being similar to the sum of individual electrode phosphenes. Simultaneous stimulation of multiple electrodes can sometimes produce physical sensation or discomfort in the eye. Time-shifting the pulses cab also be used to reduce the physical sensations felt by the patient. | 12-17-2009 |
Alan M. Kagen, Pooler, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20080217195 | Stand Golf Bag with Mechanism to Secure Clubs - A mechanism cooperable with the stand mechanism in a stand golf bag secures the clubs in position when the bag is not on the ground and releases the clubs when the bag is set on the ground. | 09-11-2008 |
| 20100252466 | Stand Golf Bag with Mechanism to Secure Clubs - A mechanism cooperable with the stand mechanism in a stand golf bag secures the clubs in position when the bag is not on the ground and releases the clubs when the bag is set on the ground. | 10-07-2010 |
Alan M. Lambowitz, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20120009630 | STABILIZED REVERSE TRANSCRIPTASE FUSION PROTEINS - Stabilized reverse transcriptase fusion proteins including a thermostable reverse transcriptase connected to a stabilizer protein are described. Attaching the stabilizer protein to the thermostable reverse transcriptase stabilizes the fusion protein and can aid in its purification, provide increased solubility, allow for longer storage, or allow the fusion protein to be used under more rigorous conditions such as higher temperature. The stabilized reverse transcriptase fusion protein can also include a linker between the stabilizer protein and the thermostable reverse transcriptase. The stabilized reverse transcriptase fusion proteins are suitable for use in nucleic acid amplification methods such as the reverse transcription polymerase chain reaction and other applications involving cDNA synthesis. | 01-12-2012 |
Alan M. Laties, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090036479 | METHOD OF INHIBITING CHOROIDAL NEOVASCUARIZATION - The present invention relates to compositions and methods for inhibiting unwanted angiogenesis, particularly those of ocular tissues. The treatment, inhibition, and/or prevention of choroidal neovasculature (CNV) is provided, along with an animal model for CNV and imaging techniques that permit the screening of potential agents as anti-angiogenesis and anti-CNV agents. | 02-05-2009 |
Alan M. Lefcourt, Elkridge, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090185182 | Simultaneous Acquisition of Fluorescence and Reflectance Imaging Techniques with a Single Imaging Device for Multitask Inspection - A hyperspectral reflectance and fluorescence line-scan imaging system is used for on-line quality and safety inspection of agricultural commodities. The system simultaneously acquires hyperspectral/multispectral combinations of both fluorescence and reflectance images of the agricultural commodities. | 07-23-2009 |
| 20090309967 | Hand-held inspection tool and method - The hand-held inspection tool enhances the ability of an on-site inspector to detect and communicate the presence of contamination on an object or in an area. An on-site inspector directs an excitation light in the sensing head of the tool into an area of interest. If the targeted contamination is present, the excitation light causes the contamination to emit fluorescence. The emitted fluorescent light passes through a narrow spectral band-pass video camera filter and is detected by a video camera mounted in the tool sensing head. The video camera transmits the image to a display visible to the on-site inspector. The invention also includes a means of recording, documenting, and wirelessly communicating the inspection process so that remotely located personnel can view the inspection, and respond to the inspection findings in real time. | 12-17-2009 |
Alan M. Letzt, Purcellville, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20120046798 | Systems and Methods for Power Demand Management - A system and method for shifting power load on a power distribution network with multiple power loads, each of which draws power from the power distribution network. The system includes a controller communicatively coupled to an energy storage system and power load on the power distribution network. The controller is configured to receive a load-shifting signal, determine a load-shifting procedure, and switch one or more of the communicatively coupled power loads from drawing power from the power distribution network to drawing power from the energy storage system according to a load-shifting algorithm. | 02-23-2012 |
Alan M. Malakoff, Houston, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090156764 | Ethylene-Based Polymers and Articles Made Therefrom - Provided are ethylene-based polymer compositions, articles made therefrom, and methods of making the same. Ethylene-based polymer compositions include linear low density polyethylene prepared with metallocene catalyst, which may optionally have about 5 mole percent or less of monomer units derived from an alpha-olefin comonomer. Ethylene-based polymer compositions include blends of linear low density polyethylene and one or more very low density polyethylene compositions, one or more low density polyethylene compositions, one or more medium density polyethylene compositions, one or more high density polyethylene compositions, one or more differentiated polyethylene compositions, or other conventional polymers. Articles composed of such ethylene-based polymer compositions are prepared according to a process window, e.g., at a specific extrusion rates, which provides favorable physical properties, including tear resistance and dart drop properties. Films prepared according to these techniques exhibit physical properties equivalent to, or superior than, conventional linear low density polyethylenes prepared with Ziegler-Natta catalyst. | 06-18-2009 |
| 20090192270 | Ethylene-Based Polymers And Articles Made Therefrom - Provided are ethylene-based polymer compositions, articles made therefrom, and methods of making the same. Ethylene-based polymer compositions include blends of a linear low density polyethylene prepared with metallocene catalyst and a low density polyethylene. The linear low density polyethylene may optionally have about five mole percent or less of monomer units derived from an alpha-olefin comonomer. Articles composed of such ethylene-based polymer compositions, such as blown films, exhibit favorable physical properties, including excellent optical properties and retained strength i.e., mitigation of expected decline in physical strength due to LDPE addition. | 07-30-2009 |
Alan M. Schilowitz, Highland Park, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20080228424 | On-line absolute viscosity measurement system - The present invention provides systems and methods for determining the viscosity of a lubricating fluid in a process on line. The method of the present invention obviates the need to accurately control the temperature of the lubricating fluid in the system when taking fluid viscosity measurements. | 09-18-2008 |
| 20100324852 | DETERMINING THE RESONANCE PARAMETERS FOR MECHANICAL OSCILLATORS - The prior art describes the application of mechanical oscillators for the measurement of corrosion and/or deposition. Mechanical oscillators employ the use of resonance parameters, frequency and the quality factor Q, for the measurement of corrosion or deposition. However, the prior art does not consider the required precision for measuring frequency or Q in the presence of noise to make these measurements. In particular, the ability of the mechanical oscillator to measure small amounts of metal loss or deposition is not only dependent upon the mechanical design but is limited by the precision in determining the resonance frequency and Q. The present invention discloses methods for measuring these resonance parameters with a high precision in the presence of noise. This degree of precision is required to maximize the utility of these devices as sensitive probes for corrosion and deposition (fouling) measurement. All of the embodiments described herein employ curve fitting consistent with modeling the mechanical oscillator as a simple harmonic oscillator. This curve fitting procedure, combined with averaging and utilizing signal processing parameters to mitigate noise effects, adds considerable precision in measuring resonance parameters. | 12-23-2010 |
Alan M. Thompson, West Markham GB
| Patent application number | Description | Published |
|---|---|---|
| 20100078608 | Actuator - An actuator comprises a gear arrangement operatively connected to a rotatable input of a linearly extendable actuator device, wherein the gear arrangement comprises a pinion gear and a face gear in meshing engagement with one another. | 04-01-2010 |