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Aikawa, US
Masanori Aikawa, Chestnut Hill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090175849 | NOTCH inhibition in the treatment or prevention of atherosclerosis - The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples. | 07-09-2009 |
Mina Aikawa, Emeryville, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100216767 | QUINAZOLINES FOR PDK1 INHIBITION - The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions. | 08-26-2010 |
Mina Aikawa, Alameda, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100048561 | QUINAZOLINES FOR PDK1 INHIBITION - The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions. | 02-25-2010 |
Mina E. Aikawa, Alameda, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100234394 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF THEIR USE - New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer. | 09-16-2010 |
Mina E. Aikawa, Emeryville, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090170904 | Substituted benzimidazoles and methods of their use - New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer. | 07-02-2009 |
Ryuichi Aikawa, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100028312 | Stably transformed bone marrow-derived cells and uses thereof - The invention provides compositions comprising genetically modified bone marrow cells and related therapeutic and diagnostic methods. Transduced bone marrow cells can be therapeutically administered to a subject, such as a human patient to provide for the expression of an encoded protein in the subject in need thereof. | 02-04-2010 |
Takako Aikawa, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090063126 | Validation of the consistency of automatic terminology translation - A method of determining the consistency of training data for a machine translation system is disclosed. The method includes receiving a signal indicative of a source language corpus and a target language corpus. A textual string is extracted from the source language corpus. The textual string is aligned with the target language corpus to identify a translation for the textual string from the target language corpus. A consistency index is calculated based on a relationship between the textual string from the source language corpus and the translation. An indication of the consistency index is stored on a tangible medium. | 03-05-2009 |
| 20100076746 | COMPUTERIZED STATISTICAL MACHINE TRANSLATION WITH PHRASAL DECODER - A computerized system for performing statistical machine translation with a phrasal decoder is provided. The system may include a phrasal decoder trained prior to run-time on a monolingual parallel corpus, the monolingual parallel corpus including a machine translation output of source language documents of a bilingual parallel corpus and a corresponding target human translation output of the source language documents, to thereby learn mappings between the machine translation output and the target human translation output. The system may further include a statistical machine translation engine configured to receive a translation input and to produce a raw machine translation output, at run-time. The phrasal decoder may be configured to process the raw machine translation output, and to produce a corrected translation output based on the learned mappings for display on a display associated with the system. | 03-25-2010 |
| 20100082324 | REPLACING TERMS IN MACHINE TRANSLATION - A system described herein includes a receiver component that receives an output translation from a machine translation system, wherein the output translation is in a target language and is based at least in part upon an input to the machine translation system in a source language, and wherein the input to the machine translation system includes a first term in the source language and the output translation includes a second term in the target language that corresponds to the first term. The system additionally includes a replacer component in communication with the receiver component that accesses a dictionary of term correspondences, wherein the dictionary of term correspondences includes an indication that the input first term in the source language is desirably translated to a third term in the target language, and wherein the replacer component is configured to automatically replace the second term with the third term to modify the output translation. | 04-01-2010 |