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Aigner, DE
Achim Aigner, Marburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20120083037 | Non-Viral Transfection Agent - The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid and at least one cationic polymer. The nanofibers carry the polymer/nucleic acid complexes, wherein the non-viral transfection agent is advantageously produced by means of electrospinning. The cationic polymer is favorably a polyimine or polyethyleneimine and can be modified with one or more hydrophilic polymers coupled thereto. It can also be advantageous to couple the cationic polymer with one or more carbohydrates and/or with a receptor-specific ligand. The nucleic acid is a DNA or an RNA, or a DNA or RNA derivative, advantageously a therapeutically active nucleic acid. The nanofibers are composed of biodegradable, biocompatible polymers. The nanofibers or the entire transfection agent can be provided with a polymer coating. A method for producing a non-viral transfection agent comprises the following steps: providing the polymer/nucleic acid complex, producing a spinning solution containing the polymer/nucleic acid complexes, and electrospinning. | 04-05-2012 |
Alois Aigner, Marktl DE
| Patent application number | Description | Published |
|---|---|---|
| 20100015402 | METHOD FOR DEPOSITING A LAYER ON A SEMICONDUCTOR WAFER BY MEANS OF CVD AND CHAMBER FOR CARRYING OUT THE METHOD - A method for depositing a layer on a semiconductor wafer using chemical vapor deposition (CVD). The method includes providing a chamber having an inlet opening and an outlet opening and a channel joining the inlet opening and the outlet opening, wherein the channel is bounded at the bottom by a plane and at the top by a window transmissive to thermal radiation. A semiconductor wafer is disposed so that a surface of the semiconductor lies in the plane, wherein the window has a center region disposed over the semiconductor wafer and an edge region surrounding the center region and not disposed over the semiconductor wafer. A distance between the plane and the window varies across the chamber, the distance being greater at the edge region than at the center region. A tangent applied to a radial profile of the distance at a boundary between the center region and the edge region forms an angle with the plane of not less than 15° and not more than 25°. A deposition gas is conducted through the channel from the gas inlet opening over the semiconductor wafer to the gas outlet opening, wherein a speed at which the deposition gas is conducted varies over the semiconductor wafer according to the varying distance between the plane and the window. | 01-21-2010 |
Andreas Aigner, Siegsdorf DE
| Patent application number | Description | Published |
|---|---|---|
| 20100233337 | Steam Function at the End of a Brewing Process - A method for preparing hot beverages in a hot beverage machine by possibly repeatedly pumping a specific quantity of water from a water tank into a heating device, heating the quantity of water, pumping the heated quantity of water out of the heating device into a brewing chamber and possibly at the same time pumping a further quantity of water out of the water tank into the heating device, brewing a brewing substance contained in the brewing chamber to produce a hot beverage, and finally converting the quantity of water last pumped into the heating device completely into steam in a controlled manner for forcing liquid out of the entire line system downstream of the heating device. | 09-16-2010 |
Arno Aigner, Tuntenhausen DE
| Patent application number | Description | Published |
|---|---|---|
| 20110091921 | NOVEL 12 ALPHA-HYDROXYSTEROID DEHYDROGENASES, PRODUCTION AND USE THEREOF - The invention relates to 12 α-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, a method for producing said 12 α-hydroxysteroid dehydrogenases, a method for enzymatic oxidation of 12 α-hydroxysteroids using said enzyme, a method for enzymatic reduction of 12-ketosteroids using said enzyme, a method for qualitative or quantitative determination of 12-ketosteroids and/or 12α-hydroxysteroids using said 12α-hydroxysteroid dehydrogenases and a method for production of ursodesoxycholic acid, comprising the enzyme-catalysed cholic acid oxidation using said 12 α-hydroxysteroid dehydrogenases. | 04-21-2011 |
Christian Aigner, Vilsbiburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20090138130 | Control Unit for Controlling the Electric Current of a Solenoid Control Valve in a Manner that is Robust with Respect to the Voltage Ripple of a Vehicle Electrical System and Associated Method - In a motor vehicle control unit having a digital control circuit for controlling the electric current, in a way which is robust with respect to the voltage ripple of a vehicle on-board power system, of a control magnet valve for a motor vehicle hydraulic device with simultaneously improved dynamic behavior in response to jumps in a setpoint value current as a reference variable of the control circuit, at least one adaptive correction filter whose filter time can be adjusted dynamically on the basis of the change in level of the setpoint value current is provided in the feedback branch of the digital control circuit. | 05-28-2009 |
Georg Aigner, Reisbach DE
| Patent application number | Description | Published |
|---|---|---|
| 20090272241 | STOP RULE WITH HOLD-DOWN DEVICE FOR CIRCULAR SAW BENCHES - A stop rule for circular saw benches includes a profiled hollow body extending longitudinally with a substantially right-angled cross section, on which means are located for the attachment thereof to a table. One side of the profiled hollow body is designed as a guide member with a coplanar extension extending therefrom, which has a guide rule on the front edge thereof for low workpieces. Such guide rule extends vertically at right angles from the table, on which the guide member lies when the stop rule is in a horizontal position. The extension protruding sideways has a horizontal contact surface in the horizontal position of the stop rule, on which surface a vertically adjustable hold-down device for low work pieces is connected. | 11-05-2009 |
| 20100313727 | Apparatus for mounting a stop rule on the machine table of a table saw - The invention relates to a device for securing a stop rule ( | 12-16-2010 |
Herbert Aigner, Engelsberg DE
| Patent application number | Description | Published |
|---|---|---|
| 20090253814 | COMPACT REACTOR - The invention relates to a compact reactor that consists of a number of plates that are arranged like stacks and spaced some distance apart, whereby | 10-08-2009 |
| 20100025026 | FATIGUE-PROOF PLATE HEAT EXCHANGER - Plate heat exchanger for indirect heat exchange between at least two liquid and/or gaseous media with an essentially parallelepiped-shaped base ( | 02-04-2010 |
| 20100263846 | Plate Heat Exchanger Having Profiles - The invention describes a plate heat exchanger and a method for producing a plate heat exchanger. The plate heat exchanger consists of a multiplicity of passages | 10-21-2010 |
| 20110114302 | HEAT EXCHANGER - The invention describes a method for producing a plate heat exchanger | 05-19-2011 |
Ludwig Aigner, Regensburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20090170099 | Use of Regulatory Sequences for Specific, Transient Expression in Neuronal Determined Cells - The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein. | 07-02-2009 |
| 20110016547 | USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS - The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein. | 01-20-2011 |
| 20110020790 | USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS - The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein. | 01-27-2011 |
| 20110263678 | INHIBITORS OF TGF-R SIGNALING FOR TREATMENT OF CNS DISORDERS - The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia,—Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration. | 10-27-2011 |
Manfred Aigner, Heimstetten DE
| Patent application number | Description | Published |
|---|---|---|
| 20100145656 | Method for monitoring the operation of a medication delivery device, an electronic module, and a medication delivery system - The disclosure relates to a method for monitoring the operation of a medication delivery device, the method comprising the steps of: providing a medication delivery device, the medication delivery device comprises a medication delivery module, providing an electronic module coupled to the medication delivery device, the electronic module comprises a sensor element, a control element, and a storing element, detecting, using the sensor element, signals generated in response to a measurable operation of the medication delivery module, generating electronic data by processing, using the control element, electronic information derived from the detected signals, the electronic data comprises information about a medication delivery characteristic of at least one measurable operation of the medication delivery module, and storing the electronic data in the storing element. | 06-10-2010 |
Maria-Louisa Aigner, Frankfurt A. Main DE
| Patent application number | Description | Published |
|---|---|---|
| 20090215605 | Process of producing a glass-ceramic, the glass-ceramic made therby and its uses - The process of making the glass-ceramic includes ceramicizing a starting glass at a heating or cooling rate during the ceramicization of at least 10 K/min, so that the glass-ceramic contains at least 50% by volume of ferroelectric crystallites with a maximum diameter of from 20 to 100 nm and not more than 10% by volume of nonferroelectric crystallitesis. The glass ceramic produced by the process contains no pores or not more than 0.01% by volume of the pores and a value of e′·V | 08-27-2009 |
Maximilian Aigner, Heidelberg DE
| Patent application number | Description | Published |
|---|---|---|
| 20100062007 | MULTI-MODAL CANCER THERAPY USING VIRAL HITCH-HIKING - The present invention relates to an antibody fusion protein which specifically recognizes the VA, HN or F surface antigen of the New Castle Disease Virus (NDV), a surface molecule of a tumor-unspecific T cell or a surface molecule of a dendritic cell and an immunocytokine. Also encompassed by the present invention are polynucleotides encoding the aforementioned antibody fusion protein as well as tumor-unspecific key cells or dendritic cells bound by the antibody fusion protein. Moreover, the present invention relates to a method of treating a tumor in a subject comprising administering to the said subject the antibody fusion protein, the tumor-unspecific T cell, the dendritic cell or the polynucleotide of the invention. Preferably, the said tumor is a solid tumor. | 03-11-2010 |
Robert Aigner, Unterhaching DE
| Patent application number | Description | Published |
|---|---|---|
| 20090064477 | PIEZOELECTRIC OSCILLATING CIRCUIT, METHOD FOR MANUFACTURING THE SAME AND FILTER ARRANGEMENT - In a method for manufacturing a piezoelectric oscillating circuit in thin film technology, wherein the oscillating circuit includes a predetermined natural frequency and a plurality of layers, first of all at least a first layer of the piezoelectric oscillating circuit is generated. Subsequently, by processing the first layer a frequency correction is performed. Subsequently, at least a second layer of the piezoelectric oscillating circuit is generated and processed for performing a second frequency correction. | 03-12-2009 |
Rudolf Aigner, Kastl DE
| Patent application number | Description | Published |
|---|---|---|
| 20080306295 | Method and Device for the Sulfonation or Sulfation of Sulfonatable or Sulfatable Organic Substances and for Performing Faster, Strongly Exothermic Gas/Liquid Reactions - A method and a device for the sulfonation or the sulfation of organic liquid raw materials with an S0 | 12-11-2008 |
Silke Aigner, Frankenthal DE
| Patent application number | Description | Published |
|---|---|---|
| 20090175863 | AGENTS TARGETING CD138 AND USES THEREOF - Disclosed is a human murine chimeric antibody which substantially retains the antigen binding region of its murine counterpart and displays improved binding affinities to the antigen and/or more homogenous binding to target cells. | 07-09-2009 |
| 20090232810 | IMMUNOCONJUGATES TARGETING CD138 AND USES THEREOF - Disclosed are immunoconjugates having in particular specificity for CD138 expressed on target cells and which display homogenous targeting. The immunoconjugates may be sterially hindered and/or contain a cleavable linker. | 09-17-2009 |
| 20110059082 | AGENT FOR TREATING DISEASE - The present invention provides a pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject in a dose of the agent from 10 mg to 200 mg. | 03-10-2011 |
| 20110059083 | AGENT FOR TREATING DISEASE - The present invention provides pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject at most every 3 days. | 03-10-2011 |
| 20110059084 | AGENT FOR TREATING DISEASE - The present invention provides a pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject in a dose of the agent from 0.2 mg to 30 mg. | 03-10-2011 |
| 20110123554 | USES OF IMMUNOCONJUGATES TARGETING CD138 - Disclosed are methods and treatment regimes that include the administration of immunconjugates targeting CD138 to combat diseases. The immunoconjugate is either used as the sole active ingredient, as part of a treatment regime or as part of an anticancer combination. | 05-26-2011 |
| 20110229465 | COMPOSITION FOR TREATING DISEASE - The present invention provides pharmaceutical compositions and kits comprising an agent capable of activating CD4+CD25+ regulatory T cells and methotrexate, and methods of treatment and medical uses utilising the same. | 09-22-2011 |
Stefan Aigner, Bad Abbach DE
| Patent application number | Description | Published |
|---|---|---|
| 20090076692 | METHOD TO DETERMINE AN OPTIMIZED SHIFT POINT, IN PARTICULAR UPSHIFT POINT, FOR A MANUAL TRANSMISSION - In order to determine an optimized upshift point, it is proposed that a control circuit, on the basis of a current engine operating point (TQ | 03-19-2009 |
Thomas Aigner, Erlangen DE
| Patent application number | Description | Published |
|---|---|---|
| 20080274487 | Use of Serum/Glucocorticoid-Regulated Kinase - The invention relates to the use of an SGK protein, a functional derivative or fragment thereof, or a nucleic acid coding for one such protein, fragment or derivative, in order to discover active ingredients for the prevention or treatment of degenerative cartilage changes. | 11-06-2008 |
Werner Aigner, Willmering DE
| Patent application number | Description | Published |
|---|---|---|
| 20110153624 | DATA MODEL ACCESS CONFIGURATION AND CUSTOMIZATION - Apparatus, systems, and methods may operate to publish one or more stored back end data models accessible to a user interface and a development environment; to receive a configuration context; to generate derived model attributes by filtering, according to the configuration context, back end data attributes associated with the stored back end data models; to derive a set of mapping rules based on the derived model attributes; and store the set of mapping rules to be used to direct run-time data model request transformation activity. Further activities may include receiving an end-user request from a displayed user interface, transforming the end-user request into a transformed request according to the stored set of mapping rules, and transmitting the transformed request to one of the stored back end data models. Additional apparatus, systems, and methods are disclosed. | 06-23-2011 |
Werner Aigner, Pfarrkirchen DE
| Patent application number | Description | Published |
|---|---|---|
| 20090130960 | Method For Producing A Semiconductor Wafer With A Polished Edge - The invention relates to a method for producing a semiconductor wafer with a polished edge, said method comprising the following steps: | 05-21-2009 |