Patent application number | Description | Published |
20130035261 | USE OF N-ALKYL IMIDAZOLE FOR SULFURIZATION OF OLIGONUCLEOTIDES WITH AN ACETYL DISULFIDE - A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources. | 02-07-2013 |
20130043380 | CALIBRATION OF MASS SPECTROMETRY SYSTEMS - A method for operating a mass spectrometer (MS) includes establishing a pressure differential across a membrane wherein an upstream pressure in a calibrant gas inlet line on an upstream side of the membrane is greater than a downstream pressure in an ion source on a downstream side of the membrane; flowing a calibrant gas from the calibrant gas inlet line, through a nano-scale orifice of the membrane, and into the ion source; and maintaining the upstream pressure at a constant value. The calibrant may be flowed at a low flow rate. An MS system includes a membrane interposed between a calibrant gas introduction system and a mass spectrometer. The membrane may include an orifice of nano-scale diameter. | 02-21-2013 |
20130099113 | IN-SITU CONDITIONING IN MASS SPECTROMETER SYSTEMS - In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream. | 04-25-2013 |
20130102459 | Inorganic/Organic Hybrid Totally Porous Metal Oxide Particles, Methods For Making Them And Separation Devices Using Them - The present invention is a process for making an inorganic/organic hybrid totally porous spherical silica particles by self assembly of surfactants that serve as organic templates via pseudomorphic transformation. | 04-25-2013 |
20130123129 | USE OF DNAZYMES FOR ANALYSIS OF AN RNA SAMPLE - Provided herein is method comprising: contacting an initial RNA sample containing a population of different RNA molecules with a divalent cation and a set of DNAzymes that are designed to cleave multiple target RNAs in the initial sample, thereby producing a product RNA sample that comprises: a) uncleaved RNA molecules and b) cleaved RNA fragments that contain a 2′,3′-cyclic-phosphate and a 5′ hydroxyl as the result of DNAzyme cleavage. | 05-16-2013 |
20130127324 | PLASMA TORCH WITH MULTIPLE INLETS FOR GUIDING COOLING GAS - A plasma torch comprises: a glass inner tube comprising an outlet where a plasma is formed; a glass outer tube comprising at least three inlets for receiving a cooling gas and distributing the cooling gas between the glass outer tube and the glass inner tube; and a cartridge housing comprising a gas receiving inlet, the glass outer tube being in fluid communication with the gas receiving inlet. Any two of the at least three inlets are radially offset by fewer than 180°. | 05-23-2013 |
20130137861 | NOVEL METHODS FOR THE SYNTHESIS AND PURIFICATION OF OLIGOMERS - A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of: | 05-30-2013 |
20130161517 | ADJUSTABLE APERTURE DEVICE WITH INTEGRAL APERTURE HOLES - An adjustable aperture device for an electromagnetic radiation detecting apparatus includes a position adjustment body configured for adjusting a position of a selected aperture hole of multiple selectable aperture holes, where electromagnetic radiation propagates through the selected aperture hole. The adjustable aperture device further includes a guide unit configured for guiding the position adjustment body along a predefined guide direction, and an aperture body defining the aperture holes and including multiple engagement sections, where the adjustment body is engagable in a selectable one of the engagement sections to thereby select the selected aperture hole. The adjustable aperture device further includes a pre-loading element configured for pre-loading the position adjustment body towards the aperture body, and a drive unit configured for driving the aperture body to move so that the position adjustment body is engaged in a respective one of the plurality of engagement sections. | 06-27-2013 |
20130170843 | OPTICAL COHERENT RECEIVER WITH LOCAL OSCILLATOR LASER HAVING HYBRID CAVITY - A coherent optical receiver includes a local oscillator (LO) laser configured to provide an LO signal. The LO laser includes a hybrid external cavity and an active gain medium within the hybrid external cavity, where the LO laser is defined between a first optical reflector on a chip including the active gain medium and a second optical reflector not on the chip. | 07-04-2013 |
20130175442 | INDUCTIVELY COUPLED PLASMA MS/MS MASS ANALYZER - An inductively coupled plasma MS/MS mass analyzer (ICP-MS/MS) may include a first vacuum chamber which draws plasma containing an ionized sample into vacuum, a second vacuum chamber which includes a device or means which extracts and guides ions as an ion beam from the ions output from the first vacuum chamber, a third vacuum chamber which has a first ion optical separation device or means, a fourth vacuum chamber which has a cell into which reaction gas is introduced, and a fifth vacuum chamber which has a second optical separation device or means and a detector, wherein the second vacuum chamber and third vacuum chamber are individually evacuated. | 07-11-2013 |
20130192698 | LOW NOISE BACK PRESSURE REGULATOR FOR SUPERCRITICAL FLUID CHROMATOGRAPHY - A drive mechanism for back pressure regulator used in liquid chromatography, supercritical fluid chromatography, or supercritical fluid extraction allows very fine automated control over a very wide range of pressures by combining a linear actuator compressing a spring, pushing a pin. The nozzle assembly of the regulator comprises a flow through chamber containing a diaphragm and a seat, in which the pin pushes the diaphragm against the seat, together with an upstream pressure sensor and electronic feedback control to the motor of the actuator. The BPR of the embodiments exhibits high pressure stability and extremely low pressure noise, even at moderate to high pressures. The exemplary BPR can be use at either constant pressure or to generate pressure programs where the pressure is varied versus time. Further, the nozzle assembly has a field-replaceable head, requiring no mechanical adjustment on replacement. | 08-01-2013 |
20130193318 | ION SOURCE FOR MASS SPECTROMETERS - Ion sources for use in mass spectrometry (MS) systems are described. The ion sources each comprise an ion funnel and an ionization source configured to ionize neutral analyte molecules. | 08-01-2013 |
20130194160 | COMPACT, ULTRA-BROADBAND ANTENNA WITH DOUGHNUT-LIKE RADIATION PATTERN - A compact, ultra-broadband antenna with doughnut-like radiation pattern is provided as including a first assembly having first and second ends; a second assembly having first and second ends, the first and second ends each configured to have a substantially hemispherical shape; and a cable configured to extend through the first and second assemblies and out each of the first and second ends. | 08-01-2013 |
20130195129 | PHASE-CONTINUOUS TUNABLE LASER - A tunable laser comprises a first tuner configured to select an emission wavelength of the laser a second tuner configured to adjust a cavity mode of the laser by modifying the cavity optical path length. The second tuner is constrained by a finite tuning range. The tunable laser also comprises a controller configured to control the first and second tuners to select the emission wavelength and adjust the cavity mode in synchronization to perform phase-continuous tuning across a range larger than supported by the finite tuning range of the second tuner. | 08-01-2013 |
20130199981 | FERRULE CHUCK WITH SURFACE MICRO-GRIP - A fitting for coupling a capillary to another component of a fluidic device is disclosed. The fitting includes a ferrule configured for enclosing a front part of the capillary and for contributing to a fluidic sealing between the fitting and the other component; a ferrule chuck configured for enclosing a back part of the capillary; and a housing configured for accommodating at least a part of the ferrule chuck and for pushing the ferrule chuck against the ferrule. | 08-08-2013 |
20130200751 | CHARGE CORRECTION FOR PIEZOELECTRIC ACTUATOR - A system comprises a voltage source, a piezoelectric material arranged in a first current path between the voltage source and a first reference voltage, a capacitor arranged in a second current path between the voltage source and a second reference voltage, and a correction circuit configured to adjust the first reference voltage to increase or decrease the current in the first current path according to the current in the second current path. | 08-08-2013 |
20130202020 | METHOD OF GENERATING INTERFERENCE SIGNALS AND DEVICE TO CARRY OUT SUCH A METHOD - A method for generating interference signals and a device to carry out said method, in which an interference signal ( | 08-08-2013 |