Patent application number | Description | Published |
20090074798 | System and method for the production of recombinant glycosylated proteins in a prokaryotic host - A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. | 03-19-2009 |
20100062484 | Recombinant n-glycosylated proteins from procaryotic cells - The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as well as corresponding vectors and host cells. In addition, the present invention is directed to the use of said proteins, nucleic acids, vectors and host cells for preparing medicaments. Furthermore, the present invention provides methods for producing said proteins. | 03-11-2010 |
20110207214 | NOVEL TOOLS FOR THE PRODUCTION OF GLYCOSYLATED PROTEINS IN HOST CELLS - The invention improves glycoprotein production and protein glycosylation engineering in eukaryotes, specifically the production of human-like complex or hybrid glycosylated proteins in lower eukaryotes such as yeasts. The invention provides glycosylation modified eukaryotic host cells capable of producing glycosylation optimized proteins useful as immunoglobulins and other therapeutic proteins, and provides cells capable of producing glycoproteins having glycan structures similar to glycoproteins produced in human cell. The invention further provides proteins with human-like glycan structures and novel compositions thereof producible by these cells. | 08-25-2011 |
20120064541 | N-GLYCAN CORE BETA-GALACTOSYLTRANSFERASE AND USES THEREOF - The present invention relates to new galactosyltransferases, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto. | 03-15-2012 |
20120100177 | SALMONELLA ENTERICA PRESENTING C. JEJUNI N-GLYCAN OR DERIVATIVES THEREOF - The present invention relates to | 04-26-2012 |
20120207737 | MEDICAL UTILITY OF GLYCAN-BINDING PROTEINS AND GLYCANS - The present invention relates to the use of glycan-binding polypeptides and glycans as a medicament, in particular for treating and/or preventing helminthic infections or an immune disease. Moreover, the present invention is directed to corresponding pharmaceutical compositions, food products and animal feed comprising isolated glycans and/or glycan-binding polypeptides. In addition, the present invention teaches methods for identifying anti-helminthic carbohydrate-binding polypeptides, for identifying helminthic glycan and gene targets involved in glycan-mediated toxicity, for identifying helminths susceptible to glycan-mediated toxicity, and for identifying anti-helminthic and anti-allergic substances. | 08-16-2012 |
20130040897 | GLYCOSYLATION OF PROTEINS IN HOST CELLS - The invention provides means and methods for an improved production of glycosylated recombinant proteins in lower eukaryotes, specifically the production of human-like complex or hybrid glycosylated proteins in yeast. The invention provides genetically modified eukaryotic host cells capable of producing glycosylation optimized proteins useful as immunoglobulins and other therapeutic proteins, and provides cells capable of producing glycoproteins having glycan structures similar to glycoproteins produced in human cell. The invention further provides proteins with human-like glycan structures and novel compositions thereof producible by these modified cells. | 02-14-2013 |
20140194346 | PASTEURELLACEAE VACCINES - The present invention relates to an N-glycosylated protein for treating and/or preventing bacterial Pasteurellaceae infection in a mammal or bird, wherein the protein is a Pasteurellaceae protein, a functional fragment or derivative thereof having at least one glycosylated N-X-S/T consensus sequence. In addition, the present invention is directed to corresponding pharmaceutical compositions for treating and/or protecting mammals or birds having or being prone to develop a bacterial Pasteurellaceae infection. Furthermore, the invention describes methods for producing said N-glycosylated proteins. | 07-10-2014 |
20140323700 | RECOMBINANT N-GLYCOSYLATED PROTEINS FROM PROCARYOTIC CELLS - The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as well as corresponding vectors and host cells. In addition, the present invention is directed to the use of said proteins, nucleic acids, vectors and host cells for preparing medicaments. Furthermore, the present invention provides methods for producing said proteins. | 10-30-2014 |
20140335127 | SYSTEM AND METHOD FOR THE PRODUCTION OF RECOMBINANT GLYCOSYLATED PROTEINS IN A PROKARYOTIC HOST - A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. | 11-13-2014 |
20150203828 | N-GLYCAN CORE BETA-GALACTOSYLTRANSFERASE AND USES THEREOF - The present invention relates to new galactosyltransferases, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto. | 07-23-2015 |
Patent application number | Description | Published |
20110264222 | DEVICE FOR ESTABLISHING AN ANATOMICAL REFERENCE POINT OF AN INTERVERTEBRAL DISC - The disclosure relates to a device for establishing an anatomical reference point of an intervertebral disc for the attachment of at least one instrument intended for the implantation, through a posterior or posterolateral approach, of a disc prosthesis or osteosynthesis cage as a replacement for the intervertebral disc. The device includes at least two means for bone anchorage each intended to be attached to a vertebra adjacent to the disc, a coupling element for the instrument and elements for adjusting the position of the coupling element relative to the position of the disc. | 10-27-2011 |
20120116517 | Device for Establishing an Anatomical Reference Point of an Intervertebral Disc - The disclosure relates to a device for establishing an anatomical reference point of an intervertebral disc for the attachment of at least one instrument Intended for the implantation, through a posterior or posterolateral approach, of a disc prosthesis or osteosynthesis cage as a replacement for the intervertebral disc. The device includes at least two means for bone anchorage each intended to be attached to a vertebra adjacent to the disc, a coupling element for the instrument and elements for adjusting the position of the coupling element relative to the position of the disc. | 05-10-2012 |
20120123415 | Devices, Methods and Systems for Remedying or Preventing Fractures - Devices, methods and systems for remedying or preventing fractures of the bone are disclosed. The devices, and corresponding methods and systems, may include first and second members each having a proximal end, a distal end and a middle portion and an outer surface. The first member may be configured to be positioned at least partially within the femoral neck of the femur. The second member may be configured to be oriented at an oblique angle relative to the first member and mechanically engaged with the first member through an interlocking connection between the distal end of the second member and the middle portion or the distal end of the first member. | 05-17-2012 |
Patent application number | Description | Published |
20110281553 | METHOD AND SYSTEM FOR LOCATION-DEPENDENT BILLING FOR SERVICES - A method for location-dependent billing for a services that are available to a mobile terminal, a local communication connection is set up to a fixably installed external location tag with a corresponding wireless interface between the fixably installed tag and the mobile terminal, the method including the steps of accessing the external location tag and transmitting a billing rate code from the external location tag to the mobile terminal, forwarding the billing rate code from the mobile terminal to a central unit of a mobile communication network, in which the mobile terminal is logged, determining a geographic location identification of the external location tag by evaluation of the billing rate code at the central unit, and selecting a billing rate for billing for the service available to the user based on the billing rate code at the central unit. | 11-17-2011 |
20120289190 | METHOD AND SYSTEM FOR LOCATION-DEPENDENT BILLING FOR SERVICES - A method and system for location-dependent billing for services that are available to mobile terminals. A mobile terminal may access a fixably installed external location tag, and may obtain from the external location tag a billing rate code, which may then be forwarded from the mobile terminal to a central unit of a mobile communication network, in which the mobile terminal is logged. The central unit may determine a geographic location identification of the external location tag—e.g., by evaluation of the billing rate code—and may select a billing rate for billing for service(s) available to the user, based on the billing rate code at the external location tag. The mobile terminal may access the external location tag via a local communication connection, which may be set up between the mobile terminal and external location tag, such as using a corresponding wireless interface therebetween. | 11-15-2012 |
20150181048 | Method and System for Location-Dependent Billing for Services - A method for location-dependent billing for a services that are available to a mobile terminal, a local communication connection is set up to a fixably installed external location tag with a corresponding wireless interface between the fixably installed tag and the mobile terminal, the method including the steps of accessing the external location tag and transmitting a billing rate code from the external location tag to the mobile terminal, forwarding the billing rate code from the mobile terminal to a central unit of a mobile communication network, in which the mobile terminal is logged, determining a geographic location identification of the external location tag by evaluation of the billing rate code at the central unit, and selecting a billing rate for billing for the service available to the user based on the billing rate code at the central unit. | 06-25-2015 |
Patent application number | Description | Published |
20110062204 | PIN CUTTING TOOL - A tool for breaking a shaft has a first and a second tubular element, both provided with inner through bores adapted to receive a first and second portion of a shaft in a first position of the tool. A first handle is fixedly connected with the first tubular element and the second tubular element is connected to a second handle. A bottom surface of the second tubular element is in contact with a neck surface of the first tubular element forming a shearing plane perpendicular to the main axis of the tool. A rotation between the two tubular elements around this axis creates a twisting movement of the two shaft portions received within the two tubular elements, and shears the shaft portions at the shearing plane. The second handle turns the first tubular element around an axis and has a gear engaging the second tubular element for transmitting the rotation of the second handle into a rotation of the second tubular element for producing the twisting movement. | 03-17-2011 |
20110196380 | TENSIONING DEVICE FOR SURGICAL ELEMENTS - A tensioning device for surgical elements is described. The tensioning device comprises a fixation device, a clamping device, a spring device, and a force deflecting device that interacts with the clamping device. The force deflecting device is designed to convert the spring force exerted by the spring device on the clamping device into a clamping force exerted by the clamping device on the surgical element. | 08-11-2011 |
20120271308 | SURGICAL CLAMPING DEVICE - A surgical clamping device is provided for receiving distal ends of handles having bone attachment members disposed thereon in a recess disposed in the surgical clamping device. When an adjustment mechanism is in a first state, the distal ends of the handles are able to pivot and, optionally, to move axially within the recess of the surgical clamping device. When the adjustment mechanism is placed into a second state by adjusting the adjusting mechanism, the surgical clamping device applies a clamping force to the distal ends of the handles such that they are fixed within the recess of the surgical clamping device. | 10-25-2012 |
20150157337 | Aiming Device For Targeted Drilling Of Bone - An aiming device for targeted drilling of a hole into bone includes a slot hole extending through the aiming device, the slot hole being configured to receive a guide sleeve therein at different locations therein and at different angles each of which corresponds with one of the locations along a longitudinal extension of the slot hole. The aiming device can be positioned relative to a bone plate using a positioning device including a base having a guide hole extending therethrough from a first side of the base to a second side of the base. The guide hole is formed as an elongated hole and is configured to receive the guide sleeve therein at different angles relative to the positioning device. | 06-11-2015 |
20150157373 | Bone Plate - A bone plate includes a first surface which, when the bone plate is positioned over a bone, faces the bone, and a second surface opposing the first surface, the bone plate comprising an elongate shaft portion extending along a longitudinal axis of the bone plate and including a plurality of through holes extending therethrough from the first surface to the second surface to receive a bone anchor therethrough and a head portion extending from an end of the elongate shaft portion along a length smaller than a length of the elongate shaft portion, a width of the head between lateral walls connecting edges of the first and second surface being greater than a width of the shaft distance between the lateral walls, wherein the second surface includes a cavity extending between a first one of the plurality of through holes situated closest to the head portion and the head portion. | 06-11-2015 |
20150182267 | Method and Device for Attaching a Bone Plate - A method and device are for attaching a bone plate to a bone includes the steps of placing a first surface of a wire insertion device against the bone, inserting a reference wire through an opening of the wire insertion device extending therethrough from the first surface of the wire insertion device to a second surface of the wire insertion device, removing the wire insertion device from the reference wire and positioning a bone plate on the bone by moving the bone plate in a transverse direction relative to a longitudinal axis of the reference wire so that the reference wire is received within a slot of the bone plate, the bone plate including a first surface facing toward the bone and a second surface opposing the first surface, the slot open to a lateral side surface connecting edges of the first and second surfaces. | 07-02-2015 |