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Addison, GB
Adrian Charles Addison, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090123778 | FRICTION STIR METHOD AND A PAIR OF WORKPIECES JOINT BY SUCH METHOD - A friction stir method comprises causing a rotating probe ( | 05-14-2009 |
Deborah Addison, Lancaster GB
| Patent application number | Description | Published |
|---|---|---|
| 20100198127 | Layered materials for use as wound dressings - The invention provides a wound dressing comprising a layered material comprising a hydrophilic foam layer formed from a first polyurethane and a hydrogel layer formed from a second polyurethane, wherein the hydrogel layer is laminated to the hydrophilic foam layer. The invention also provides methods for preparing a layered structure for use as a cavity wound dressing comprising the steps of: providing a first, foamed polyurethane layer by reacting an isocyanate-capped prepolymer with water and optionally one or more compounds selected from polyurethane chain extending or terminating compounds other than water and catalysts for the polymerisation of isocyanate; providing a second, hydrogel polyurethane layer by reacting an isocyanate-containing prepolymer with one or more compounds selected from water, other polyurethane chain extending or terminating compounds and catalysts for the polymerisation of isocyanate; laminating the second layer to the first layer; curing and drying the polyurethane layers to provide the layered material, wherein the method further comprises slitting the layered material before said step of curing and drying is complete. | 08-05-2010 |
Deborah Addison, Keasden GB
| Patent application number | Description | Published |
|---|---|---|
| 20090275872 | FLUID WOUND DRESSING COMPRISING PARTIALLY CURED POLYURETHANE - A wound dressing composition comprising a partially cured polyurethane fluid. The composition can be injected directly into a wound, where it cures to form a wound filling dressing. Also provided is a wound dressing comprising such a composition. Also provided is a kit for the preparation of such wound dressings, the kit comprising (a) a polyurethane prepolymer; and (b) a curing agent for the polyurethane prepolymer. Preferably, the polyurethane components comprise reaction products of a diisocyanate with castor oil or a related ester of ricinoleic acid or its derivatives. | 11-05-2009 |
| 20100063467 | Hydrogel Wound Dressings Exhibiting Reduced Fiber Losses in Use - A wound dressing comprising: a water-absorbent fabric comprising at least about 10 wt. % of hydrogel-forming absorbent fibers based on the dry weight of the fabric; and an adhesion-resistant, water-permeable wound contacting surface textile layer that is substantially continuously bonded to at least one surface of said fabric. The surface textile layer may be formed by surface treatment of the fabric, or by bonding a suitable textile web to the surface of the fabric. | 03-11-2010 |
Glyn Addison, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20100204224 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS - Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents; wherein (1) represents (A), (B) or (C); R | 08-12-2010 |
Glynn Addison, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20100210639 | 9H-PYRIMIDO[4,5-B]INDOLES, 9H-PYRIDO[4',3':4,5]PYRROLO[2,3-D]PYRIDINES, AND 9H 1,3,6,9 TETRAAZA-FLUORENES AS CHK1 KINASE FUNCTION INHIBITORS - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain tricyclic compounds (referred to herein as TC compounds), and especially certain 9H-pyrimido[4,5-b]indole, 9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyridine, and 9H-1,3,6,9-tetraaza-fluorene compounds, which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation. | 08-19-2010 |
Glynn Jonathan Addison, Babraham GB
| Patent application number | Description | Published |
|---|---|---|
| 20120040967 | Pyrazin-2-yl-pyridin-2-yl-amine and pyrazin-2-yl-pyrimidin-4-yl-amine Compounds and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain biarylamine compounds (referred to herein as BAA compounds), and especially certain pyrazin-2-yl-pyridin-2-yl-amine and pyrazine-2-yl-pyrimidin-4-yl-amine compounds, which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation. | 02-16-2012 |
Paul Addison, Edinburgh GB
| Patent application number | Description | Published |
|---|---|---|
| 20110276275 | Systems And Methods For Wavelet Transform Scale-Dependent Multiple-Archetyping - Methods and systems are disclosed for producing a plurality of archetype signals in wavelet space at a plurality of wavelet scales. A signal is transformed using a continuous wavelet transform based at least in part on a wavelet function. A scale dependent archetype transformed signal is computed based at least in part on the transformed signal and based at least in part on a natural periodicity of the wavelet function used to transform the signal. Information may be derived about the signal from the archetype transform signal, and stored in memory. | 11-10-2011 |
Paul S. Addison, Edinburgh GB
| Patent application number | Description | Published |
|---|---|---|
| 20090326349 | Consistent Signal Selection By Signal Segment Selection Techniques - According to embodiments, techniques for selecting a consistent part of a signal, including a photoplethysmograph (PPG) signal, are disclosed. A pulse oximetry system including a sensor or probe may be used to obtain a PPG signal from a subject. Signal peaks may be identified in the PPG signal. Characteristics of the signal peaks, including the amplitude levels of the signal peaks and/or the time-distance between the signal peaks may be used to determine if the PPG signal is consistent. In an embodiment, signal peaks are processed based on a consistency metric, and the processed signal peaks are compared to the consistency metric to determine if the PPG signal is consistent. If the PPG signal is determined to be consistent, the PPG signal may be further analyzed to determine an underlying signal parameter, including, for example, a patient respiration rate. If the PPG signal is determined to be inconsistent, the inconsistent portion of the signal may be removed from the overall signal or otherwise transformed. | 12-31-2009 |
| 20100286495 | Selection Of Signal Regions For Parameter Extraction - According to embodiments, techniques for extracting a signal parameter from a selected region of a generally repetitive signal are disclosed. A pulse oximetry system including a sensor or probe may be used to obtain an original photoplethysmograph (PPG) signal from a subject. A filter transformation may be applied to the original PPG signal to produce a baseline PPG signal. The baseline PPG signal may contain artifacts and/or noise, and a region of the baseline PPG signal suitable for extracting the signal parameter may be selected. A suitable region of the baseline PPG signal may be selected by applying one or more thresholds to the baseline PPG signal, where the values of the thresholds may be set based on derivative values, amplitude-based percentiles, and/or local minima and maxima of the baseline PPG signal. A portion of the original PPG signal corresponding to the selected region may be processed, and the signal parameter may be extracted from the processed region. In an embodiment, the signal parameter may correspond to the respiration rate of a patient. | 11-11-2010 |
Paul Stanley Addison, Lothian GB
| Patent application number | Description | Published |
|---|---|---|
| 20090204162 | SIGNAL ANALYSIS - A method of analysis of medical signals is presented which provides useful clinical information concerning the state of the myocardium during cardiopulmonary resuscitation (CPR). The analysis during CPR can be used to (i) identify the underlying rhythm, (ii) provide a measure of the efficacy of CPR, and (iii) to predict the outcome from a defibrillation shock. | 08-13-2009 |
Paul Stanly Addison, Edinburgh GB
| Patent application number | Description | Published |
|---|---|---|
| 20110021929 | SYSTEMS AND METHODS FOR CONTINUOUS NON-INVASIVE BLOOD PRESSURE MONITORING - Systems and methods are disclosed herein for continuous non-invasive blood pressure (CNIBP) monitoring. Multiple reference blood pressure values may be obtained using a calibration device. These multiple reference blood pressure values may be used as calibration points for determining a relationship between the blood pressure of a patient and photoplethysmograph (PPG) signals. | 01-27-2011 |
Vanessa Addison, Suffolk GB
| Patent application number | Description | Published |
|---|---|---|
| 20120093929 | Opioid Composition for Treating Skin Lesions - The present invention relates to a composition, comprising (i) a matrix made of polymeric nanofibers, and (ii) an opioid agonist within the matrix. | 04-19-2012 |