Patent application number | Description | Published |
20090215670 | Site specific pegylated hemoglobin, method of preparing same, and uses thereof - The present invention provides pegylated hemoglobins comprising a maleimide polyethylene glycol (PEG) conjugated to a thiol moiety of a cysteine residue of hemoglobin, methods of preparing the pegylated hemoglobins, compositions and blood substitutes comprising the pegylated hemoglobins, and methods of treating a subject which comprise administering to the subject blood substitutes comprising vasoinactive pegylated hemoglobins. | 08-27-2009 |
20090298746 | Pegylated hemoglobin and albumin and uses thereof - The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, wherein the PEG is a maleimide PEG, an alkylamide PEG, an iodoacetamide PEG, a p-nitro thio-phenyl PEG, a vinyl sulfone PEG, or a mixed disulfide PEG; and PEGylated albumins and PEGylated hemoglobins comprising polyethylene glycol (PEG) attached to a thiolated amino group of albumin or hemoglobin, wherein the amino group is thiolated using dithio sulfo succinimidyl propionate (DTSSP) or dithiosuccinimidyl propionate (DTSP) or dithiobispropionimidate. The invention also provides methods of preparing PEGylated hemoglobins and PEGylated albumins comprising a) reacting hemoglobin or albumin with a thiolating agent and with a PEGylating agent, and b) capping unPEGylated reactive thiols of hemoglobin or albumin with N-ethyl maleimide. | 12-03-2009 |
20100216695 | SECOND GENERATION LOW OXYGEN AFFINITY PEGYLATED HEMOGLOBINS AS OXYGEN-CARRYING PLASMA EXPANDERS - Provided are hemoglobins having at least two chemical modifications that lower oxygen affinity, hemoglobins chemically modified by the addition of glyceraldehyde-3-phosphate, and hemoglobins having at least two specific chemical modifications. PEGylated versions of these hemoglobins are also provided, as are certain tetraPEGylated and diPEGylated hemoglobins. Methods of modifying a hemoglobin are additionally provided, as are methods of making a hemoglobin. Pharmaceutical compositions and blood substitutes using these hemoglobins are further provided, as are methods of treating a subject using these pharmaceutical compositions and blood substitutes. | 08-26-2010 |
20100222260 | Uses of pegylated albumin - The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutically effective amount of a PEGylated albumin. | 09-02-2010 |
20130261061 | METHOD OF ENHANCING EFFICACY OF BLOOD TRANSFUSIONS - A method of improving the efficacy of a blood transfusion into a subject is provided comprising administering a composition comprising an EAF PEGylated-blood protein into the subject, prior to, during, or subsequent to the blood transfusion. | 10-03-2013 |
20140256636 | PEGYLATED HEMOGLOBIN AND ALBUMIN AND USES THEREOF - The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, wherein the PEG is a maleimide PEG, an alkylamide PEG, an iodoacetamide PEG, a p-nitro thio-phenyl PEG, a vinyl sulfone PEG, or a mixed disulfide PEG; and PEGylated albumins and PEGylated hemoglobins comprising polyethylene glycol (PEG) attached to a thiolated amino group of albumin or hemoglobin, wherein the amino group is thiolated using dithio sulfo succinimidyl propionate (DTSSP) or dithiosuccinimidyl propionate (DTSP) or dithiobispropionimidate. The invention also provides methods of preparing PEGylated hemoglobins and PEGylated albumins comprising a) reacting hemoglobin or albumin with a thiolating agent and with a PEGylating agent, and b) capping unPEGylated reactive thiols of hemoglobin or albumin with N-ethyl maleimide. | 09-11-2014 |
20150017146 | METHOD OF ENHANCING EFFICACY OF BLOOD TRANSFUSIONS - A method of improving the efficacy of a blood transfusion into a subject is provided comprising administering a composition comprising an EAF PEGylated-blood protein into the subject, prior to, during, or subsequent to the blood transfusion. | 01-15-2015 |
Patent application number | Description | Published |
20080313669 | Targeted Advertisement Insertion with Interface Device Assisted Switching - Advertisements or other types of targeted information are delivered to a set-top box or other user interface device of signal distribution system. In one aspect of the invention, a detection server of the system detects at least one cue associated with a first media stream, and generates timing information from the detected cue. The timing information is signaled to the interface device. An advertisement server of the system generates a second media stream containing targeted information for delivery to the user interface device. The user interface device switches from the first stream to the second stream based on the timing information. The timing information may also be signaled by the detection server to the advertisement server, for use in controlling generation of the second stream. | 12-18-2008 |
20100050227 | Update Process for Interface Device Based Targeted Information Insertion - Advertisements or other types of targeted information are delivered to set-top boxes or other user interface devices of a signal distribution system. In one aspect of the invention, at least one multicast update comprising updated targeted information is sent to the user interface devices during a multicast update period. If a given one of the user interface devices is unable to obtain a complete set of the updated targeted information from the multicast update before timeout of the multicast update period, a unicast update comprising at least a portion of the updated targeted information is sent to the given user interface device during a unicast update period. The unicast update may be sent responsive to a request from the given user interface device for a designated portion of the updated targeted information. | 02-25-2010 |
20100083305 | Interface Device Having Multiple Software Clients to Facilitate Display of Targeted Information - Advertisements or other types of targeted information are delivered to set-top boxes or other user interface devices of a signal distribution system. In one aspect of the invention, a user interface device comprises at least first and second software clients and a video buffer. The first software client receives packets associated with a first media stream, and the second software client receives packets associated with a second media stream containing the targeted information. The first software client delivers at least a portion of the packets associated with the first media stream to the video buffer. The second software client delivers at least a portion of the packets associated with the second media stream to the video buffer while one or more packets of the first media stream are still in the video buffer. The user interface device switches from the first media stream to the second media stream based on timing information which may be received from an external detection server. | 04-01-2010 |
20100217885 | Access Node Based Targeted Information Insertion - Advertisements or other types of targeted information are delivered to set-top boxes or other user interface devices of a signal distribution system. In one aspect of the invention, an access node sends a message to the user interface device directing the user interface device to switch from a content stream to a targeted information stream at a specified time. Responsive to the message, the access node receives a request from the user interface device to join a targeted multicast group associated with the targeted information stream. Without requiring receipt of a subsequent request from the user interface device to leave a content multicast group associated with a content stream, the access node causes the user interface device to be dropped from the content multicast group prior to the specified time. The access node then delivers the targeted information stream to the user interface device via the targeted multicast group. | 08-26-2010 |