Patent application number | Description | Published |
20130017313 | METHOD FOR FABRICATING MEDICAL DEVICES WITH POROUS POLYMERIC STRUCTURES - Medical articles with porous polymeric structures and methods of forming thereof are disclosed. The porous structure can have pores sizes that are nanoporous or greater than nanoporous. The porous structure can be a coating or layer of a medical device such as a stent, stent graft, catheter, or lead for pacemakers or implantable cardioverter defibrillators. Additionally, the body of the medical device can be a porous polymeric structure. The porous structure can be made from bioabsorbable polymers. The porous structures can be formed by contacting a polymer with a supercritical fluid. | 01-17-2013 |
20130017314 | METHOD FOR FABRICATING MEDICAL DEVICES WITH POROUS POLYMERIC STRUCTURES - Medical articles with porous polymeric structures and methods of forming thereof are disclosed. The porous structure can have pores sizes that are nanoporous or greater than nanoporous. The porous structure can be a coating or layer of a medical device such as a stent, stent graft, catheter, or lead for pacemakers or implantable cardioverter defibrillators. Additionally, the body of the medical device can be a porous polymeric structure. The porous structure can be made from bioabsorbable polymers. The porous structures can be formed by contacting a polymer with a supercritical fluid. | 01-17-2013 |
20130026681 | TUBE EXPANSION PROCESSES FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold. | 01-31-2013 |
20130071449 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 03-21-2013 |
20130078141 | RADIATION STERILIZATION OF MEDICAL DEVICES - A method for medical device sterilization comprises staggering a stack of packages so that a back surface of each package partially overlaps a front surface of another of the packages. Each package contains a medical device. The stack of packages are positioned so that the front surfaces of the packages face toward a radiation source. The packages are then exposed to radiation. | 03-28-2013 |
20130090718 | RADIALLY EXPANDABLE POLYMER PROSTHESIS AND METHOD OF MAKING SAME - Polymeric stents having fracture toughness and resistance to recoil after deployment are disclosed along with methods of manufacturing such stents. Improvements to mechanical characteristics and other improvements may be achieved by having polymer chains within individual stent struts oriented in a direction that is closer to or in line with the axis of the individual stent struts. The struts are connected to each other by hinge elements that are configured to bend during crimping and deployment of the stent. Ring struts form ring structures. A ring structure can have an overall curvilinear length from about 12 mm to about 15 mm. | 04-11-2013 |
20130096668 | OPTIMAL RATIO OF POLAR AND BENDING MOMENT OF INERTIA FOR STENT STRUT DESIGN - An intravascular stent is provided to be implanted in coronary arteries and other body lumens. The transverse cross-section of at least some of the stent struts have a ratio of polar and bending moments of inertia, which results in optimal resistance to stent twisting. This resistance to twisting ratio for the stent struts minimizes out of plane twisting of the struts or projecting edges of the struts when the stent is expanded from a compressed diameter to an expanded diameter in a coronary artery. | 04-18-2013 |
20130103138 | SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE - Acceleration of the endothelialization process on implantable medical devices having at least one blood-contacting surface is achieved by a microscale pattern of sub-sections of EC-inductive coatings or EC-conductive coatings and nano/macro textured surfaces. The EC-inductive coating and EC-conductive coating can be applied either on the entire surface of the blood-contacting surface or selective placed on the blood-contacting surface, for example, in particular patterns. In this regard, the EC-conductive and EC-inductive coatings can be selectively placed relative to the textured surface to achieve a desired pattern of texture surface to coatings. | 04-25-2013 |
20130119586 | METHOD TO PREVENT STENT DAMAGE CAUSED BY LASER CUTTING - Apparatus, method and system for cutting a polymeric stent including the use of a polymeric mandrel as a laser shielding device. The polymeric mandrel is allowed to roll freely within a polymeric tube that is cut into a polymeric stent. | 05-16-2013 |
20130123664 | MEDICAL DEVICE HAVING A LUBRICIOUS COATING WITH A HYDROPHILIC COMPOUND IN AN INTERLOCKING NETWORK - A medical device having a lubricious coating on at least a section of the medical device, and a method of coating a medical device, the lubricious coating being a network of short chain and long chain hydrophilic compounds cross-linked to one another and interlocked with a network of a cross-linked polymerized multifunctional monomer or polymer. The coating can include one or more agents which provide enhanced adhesion of the coating on the device, or which provide faster hydration of the coating and/or improved lubricity. Additionally, the lubricious coating can be provided with one or more therapeutic or diagnostic agents, and in one embodiment the agent elutes relatively quickly in a concentrated release from the lubricious coating upon hydration of the coating. | 05-16-2013 |
20130123905 | OFFSET PEAK-TO-PEAK STENT PATTERN - The invention is directed to an expandable stent for implanting in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. The invention provides for an intravascular stent having a plurality of cylindrical rings connected by links. The links between adjacent rings provide axial strength when subjected to longitudinal compressive forces. | 05-16-2013 |
20130129794 | Poly(Ester Amide)-Based Drug Delivery Systems - Implantable medical devices including a coating having a bioactive agent and a poly(ester amide) polymer. Methods of forming these coatings are also described. | 05-23-2013 |
20130129814 | Regional Delivery Of Therapeutic Agents For The Treatment Of Vascular Diseases - The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well. | 05-23-2013 |
20130129817 | METHOD OF TREATING MALIGNANT SOLID TUMORS - This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of a drug capable of inhibiting mTOR and/or inhibiting an efflux pump and/or inhibiting HIF-1α and VEGF, the drug in particular being selected from the group consisting of sirolimus, everolimus, zotarolimus, tacrolimus, iolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, novolimus, 40-O-(3-hydroxypropyl), 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin and 40-O-tetrazolylrapamycin, the drug being administered along with a chemotherapeutic agent and/or radiation therapy. | 05-23-2013 |
20130131550 | GUIDEWIRE HAVING LINEAR CHANGE IN STIFFNESS - The invention is directed to a guidewire having a distal section with multiple distally tapered core segments with at least two contiguous distally tapering core segments in which the most distal tapered core segment preferably has a greater degree of taper than the proximally contiguous tapered core segment. The invention is also directed to an elongated intracorporeal device, preferably a guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal section of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that preferably is configured to produce a linear change in stiffness of the core over a longitudinal section of the device. | 05-23-2013 |
20130134620 | METHODS FOR FABRICATING POLYMER-BIOCERAMIC COMPOSITE IMPLANTABLE MEDICAL DEVICES - Methods relating to polymer-bioceramic composite implantable medical devices are disclosed. | 05-30-2013 |
20130134623 | FABRICATING AN IMPLANTABLE MEDICAL DEVICE FROM AN AMORPHOUS OR VERY LOW CRYSTALLINITY POLYMER CONSTRUCT - Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing, nucleating agents, or both are disclosed herein. A polymeric construct that is completely amorphous or that has a very low crystallinity is annealed with no or substantially no crystal growth to increase nucleation density. Alternatively, the polymer construct includes nucleating agent. The crystallinity of the polymer construct is increased with a high nucleation density through an increase in temperature, deformation, or both. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the increase in crystallinity. | 05-30-2013 |
20130136847 | MANUFACTURING PROCESSES FOR MAKING MEDICAL DEVICES HAVING A COATING GRADIENT - Methods for forming a “coating gradient” on medical devices, such as a balloon catheter or guidewire are disclosed. The balloon portion of the catheter could have a protective covering initially placed over it to prevent the balloon from receiving a first hydrophilic coating. After a first hydrophilic coating is applied to the catheter, the protective covering can be removed exposing the uncoated surface of the balloon. Next, after the protective covering has been removed, a second hydrophilic coating could be applied to the catheter. A guidewire having less lubricity at the distal end portion of the guidewire than the shaft portion which extends proximally away from the distal end section can be created. The method includes the application of a first hydrophilic coating on the elongated shaft and distal shaft section of the guidewire. This first hydrophilic coating is then allowed to cure. Next, the first hydrophilic coating is removed from a portion of the distal shaft section of the guidewire. After the first coating has been removed, a second hydrophillic coating can be applied to the elongated shaft and distal shaft section of the guidewire. The second hydrophilic coating can be allowed to cure. | 05-30-2013 |
20130138038 | CATHETER HAVING A READILY BONDABLE MULTILAYER SOFT TIP - A balloon catheter having a soft distal tip member having a non-tacky inner (liner) layer material and a soft flexible outer layer material, with both materials being readily thermally bondable to the catheter balloon. | 05-30-2013 |
20130138081 | METHOD AND MEDICAL DEVICE HAVING TISSUE ENGAGING MEMBER FOR DELIVERY OF A THERAPEUTIC AGENT - Method of delivering a therapeutic agent includes delivering at least a portion of a medical device within a vasculature. The medical device includes a tubular member having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member proximate the distal end of the tubular member, a tissue engaging member proximate the expandable member, a sheath disposed over the tissue engaging member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The method further includes deploying the tissue engaging member at a select location by displacement of the sheath relative the tissue engaging member, inflating the expandable member to engage the therapeutic agent with a vessel wall, deflating the expandable member, and withdrawing the medical device from the vasculature. | 05-30-2013 |
20130142940 | STENT SPIN COATING METHOD AND SYSTEM - A method for removing excess coating from a stent involves simultaneously applying a coating substance to the stent, rotating the stent about a first axis of rotation, and rotating the stent about a second axis of rotation parallel to the first axis of rotation. An apparatus for removing excess coating from a stent includes a first system configured to rotate the stent about an axis of rotation, a fixture configured to support the stent such that a longitudinal axis of the stent is generally parallel to the axis of rotation, and a second system configured to rotate the stent about the longitudinal axis of the stent while the stent is supported by the fixture. | 06-06-2013 |
20130145729 | Methods of Providing Antioxidants to Implantable Medical Devices - Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices. | 06-13-2013 |
20130149432 | METHOD FOR FORMING A COATING ON A STENT - A stent has first and second members. The stent is supported by a mandrel in a first position such that the mandrel is in contact with the first member and the second member is spaced from the mandrel. A method for coating the stent includes spraying or drying the stent, placing the stent in a second position such that the first member is spaced from the mandrel and the second member is placed in contact with the mandrel, and spraying or drying the stent while the stent is supported by the mandrel in the second position. | 06-13-2013 |
20130150948 | Polymeric Stents and Method of Manufacturing Same - A pattern is used to form a stent scaffold from a polymeric precursor tube having a particular outer diameter. A new pattern can be derived from a base pattern, wherein the new pattern can be used to form a stent scaffold from a precursor tube having an outer diameter OD | 06-13-2013 |
20130150953 | Kits Including Implantable Medical Devices and Antioxidants - Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices. | 06-13-2013 |
20130156850 | APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT - A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I. | 06-20-2013 |
20130160932 | BALLOON CATHETER TAPERED SHAFT HAVING HIGH STRENGTH AND FLEXIBILITY AND METHOD OF MAKING SAME - Method of making a balloon catheter includes melt-extruding a thermoplastic polymeric material into a tube, cooling the extruded tube, placing the extruded tube within a capture member and biaxially orienting the polymeric material of the extruded tube while simultaneously tapering at least a section of the extruded tube by radially expanding the extruded tube with pressurized media in the tube lumen and axially expanding the extruded tube with an external load applied on at least one end of the tube as an external heat supply traverses longitudinally from a first end to a second end of the extruded tube in the capture member, wherein an overall axial load on the tubing is varied as at least a section of the tube is heated. The method includes cooling the expanded tube to form a tapered biaxially oriented nonporous thermoplastic polymer tubular member and sealingly securing a balloon proximate a distal end of the tubular member. | 06-27-2013 |
20130165858 | APPARATUS TO PREVENT REPURFUSION INJURY - Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion. | 06-27-2013 |
20130165903 | METHOD AND APPARATUS FOR CONTROLLED OCCLUSION - A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume. | 06-27-2013 |
20130172816 | NON-COMPLIANT MULTILAYERED BALLOON FOR A CATHETER - Balloon catheter comprises an elongate catheter shaft having a proximal section, a distal section, and an inflation lumen, and a multilayer balloon on the distal section of the shaft. The multilayer balloon comprises a first layer made of a first polymer material having a first Shore durometer hardness, a second layer made of a second polymer material having a second Shore durometer hardness lower than the first shore durometer hardness, wherein the second layer is an inner layer relative to the first layer, and an outer-most layer made of a third polymer material having a third Shore durometer hardness lower than the second Shore durometer hardness. | 07-04-2013 |
20130172817 | NON-COMPLIANT MULTILAYERED BALLOON FOR A CATHETER - Balloon catheter comprises an elongate catheter shaft having a proximal section, a distal section, and an inflation lumen, and a multilayer balloon on the distal section of the shaft. The multilayer balloon comprises at least a first layer and a second layer having a combined wall thickness and an outer-most layer. The first layer is made of a first polymer material having a first maximum blow-up-ratio. The second layer is made of a second polymer material having a second maximum blow-up-ratio greater than the first maximum blow-up-ratio and the second layer is an inner layer relative to the first layer. The at least first and second layers define a compliance less than that of a single layer balloon made of the first polymer material with a wall thickness equal to the combined wall thickness. The outer-most layer is made of a third polymer material. | 07-04-2013 |
20130172923 | FLEXIBLE LOW COMPLIANCE EXTENSION TUBING FOR BALLOON INFLATION - A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume. | 07-04-2013 |
20130172982 | POLYMER STENT WITH BREAK-AWAY LINKS FOR ENHANCED STENT RETENTION - Polymer stents with break-away links and methods of forming the links for improved stent retention on an expandable member during delivery are disclosed. | 07-04-2013 |
20130178795 | BALLOON CATHETER SHAFT HAVING HIGH STRENGTH AND FLEXIBILITY - Balloon catheter comprises an elongated shaft having a proximal end and a distal end, the elongated shaft including a biaxially oriented nonporous thermoplastic polymer tubular member having a Shore durometer hardness of less than about 75 D with an inflation lumen defined therein. The balloon catheter also comprises a balloon sealing secured proximate the distal end of the shaft and having an interior in fluid communication with the inflation lumen. | 07-11-2013 |
20130178796 | CATHETER WITH A POLYMIDE DISTAL TIP - A catheter having an elongated shaft which has a multilayered distal tip with a first layer formed of a polyimide first material and a second layer formed of a polymeric second material. In one embodiment the multilayered distal tip is a separate member, distal to the distal end of a proximal portion of the shaft. In another embodiment, the shaft has an outer tubular member, and a multilayered inner tubular member with a distal end which forms the multilayered distal tip of the shaft. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. In one embodiment, the polymeric second material is a polyamide material. | 07-11-2013 |
20130178832 | DRUG ELUTING IMPLANTABLE MEDICAL DEVICE WITH HEMOCOMPATIBLE AND/OR PROHEALING TOPCOAT - The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular diseases. | 07-11-2013 |
20130178927 | LOW PROFILE STENT WITH FLEXIBLE LINK - The invention provides an improved stent design for repairing vasculature, the stent having rings including struts defining first peaks and second peaks, selected second peaks of adjacent rings being connected by links. The stent design incorporates non-linear links with undulating portions extending generally perpendicular to or circumferentially with respect to a longitudinal axis of the stent and adjacent first peaks with different longitudinal lengths such that stent flexibility is increased without sacrificing stent compression for delivery. | 07-11-2013 |
20130181380 | Method of Making a Polymeric Stent - An endoprosthesis is made by radially expanding and axially extending a polymer tube. Next, portions of the polymer tube are removed to form an open framework of struts that define a tubular body. The tubular body has an end segment and an intermediate segment adjoining the end segment. The end segment includes a circumferential series of closed cells having a first W-shape closed cell. The intermediate segment includes a circumferential series of closed cells having a second W-shape closed cell. There are linear link struts at opposite ends of the individual first and second W-shape closed cells. The linear link struts of the first W-shape closed cell are longer than linear link struts of the second W-shape closed cell. | 07-18-2013 |
20130187313 | Controlling Crystalline Morphology of a Bioabsorbable Stent - Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed. | 07-25-2013 |
20130190725 | MEDICAL DEVICE HAVING TISSUE ENGAGING MEMBER AND METHOD FOR DELIVERY OF A THERAPEUTIC AGENT - Medical device includes a tubular member having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member proximate the distal end of the tubular member having at least one axial fold in a deflated condition, a tissue engaging member comprising at least one straight wire extending along at least part of the longitudinal axis of the expandable member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The at least one straight wire of the tissue engaging member is located inside the at least one fold of the expanded member when in the deflated condition. The tissue engaging member is configured for deployment at a select location upon inflation of the expandable member. A method of delivering a therapeutic agent is also provided. | 07-25-2013 |
20130190781 | SUTURING DEVICES AND METHODS - A surgical device for suturing body lumen is described, as well as methods for suturing tissue employing the surgical device. The device can include a body having a shaft and a foot for insertion into an opening in a body lumen. The device can include tissue ports between configured to receive tissue surrounding the opening in the body lumen. The foot can include a suture secured to needle capture devices. The device can include needles that can be advanced through tissue and into the needle capture devices. The needle capture devices can then be withdrawn, thereby harvesting the suture, which can then be used to close the opening in the body lumen. | 07-25-2013 |
20130190854 | DRUG-ELUTING STENT AND DELIVERY SYSTEM WITH TAPERED STENT IN SHOULDER REGION - A drug-eluting stent delivery system for the treatment of edge restenosis in a blood vessel. The drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent contacts a wall of the blood vessel to maintain the patency of the vessel. The drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent. A method for making the same is also disclosed herein. | 07-25-2013 |