Koch, PA
Cameron J. Koch, Swarthmore, PA US
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20090117607 | Methods For Differential Detection Of Hypoxic Tissue From A Tissue Sample Of A Mammalian Subject - Methods are provided for detecting levels of low oxygen in a tissue of a mammalian subject by administering non-polar halogen compounds to the mammalian subject. Detection may be accomplished using imaging methods involving fluorescence immunohistochemical imaging of the halogen compound. | 05-07-2009 |
Daniel E. Koch, Philadelphia, PA US
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20120310899 | SYSTEM AND METHOD FOR EFFICIENT DATA EXCHANGE IN A MULTI-PLATFORM NETWORK OF HETEROGENEOUS DEVICES - A normalization engine, system and method provide normalization of and access to data between heterogeneous data sources and heterogeneous computing devices. The engine includes connectors for heterogeneous data sources, and conduits for gathering a customized subset of data from the data sources, as required by a software application with which the conduit is compatible. Working together, the connector and conduit may gather large amounts of data from multiple data sources and prepare a subset of the data that includes only that data required by the application, which is particularly advantageous for mobile computing devices. Further, the conduit may process the subset data in various formats to provide normalized data in a single format, such as a JSON-formatted REST web service communication compatible with heterogeneous devices. As an intermediary, the normalization engine may further provide caching, authentication, discovery and targeted advertising to mobile computing and other computing devices. | 12-06-2012 |
20130219307 | SYSTEM AND METHOD FOR RUNTIME USER INTERFACE MANAGEMENT - The system allows for modification of a software application's user interface screen after compilation and/or distribution. Changes to the interface are permitted during runtime of the application, by associating a unique identification code with each user interface control of the screen. The identification code is used outside of the application to reference the controls, and to update associated information for displaying the controls. The updates may be provided as properties associated with specific identification codes contained in the application, e.g., as a playlist document created and/or received after compiling and distribution of the software application to client devices. The application includes a software development kit (SDK) for managing the receipt and application of playlist updates, prior to display of the user interface by the application. The system enables direct display and manipulation of user interface control properties in creating playlists, and manages playlist distribution, e.g., to enable multivariate testing. | 08-22-2013 |
20140082157 | SYSTEM AND METHOD FOR SELECTIVELY PERMITTING ENTRY INTO A DEFINED MODE BY DISTRIBUTED CLIENT-SIDE SOFTWARE APPLICATIONS - A system and method for permitting entry into a defined operational mode of a software application on a selective basis. To enter the limited-access mode, action must be taken at both a server and a client device. The client device stores a software application that is configured with inactive functionality for entering the predefined mode in response to user input. The server is operable to provide very limited distribution of configuration settings data to activate the functionality for recognizing predefined user input and responsively entering the predefined mode. The required predefined user input is a widely-kept secret to which access is extremely limited, and is identified to users only an as-needed basis. Accordingly, access to the defined mode is limited to users (i) having a computing device that has received the configuration settings data enabling recognition of the predefined user input, and (ii) knowing and providing the predefined user input. | 03-20-2014 |
David K. Koch, West Chester, PA US
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20130090688 | POSTERIOR VERTEBRAL PLATING SYSTEM - A posterior vertebral plating system comprising a plate and a plurality of attachment members. The plate has a plurality of holes extending through the plate from an upper surface to a lower surface, and the plate is configured to extend along the posterior side of at least two vertebrae adjacent at least one boney structure of each of the vertebrae. The holes are spaced in such a way that a first plurality of holes is positionable over a boney structure of a first vertebra to define a plurality of fixation points to the first vertebra and a second plurality of holes is positionable over boney structure of a second vertebra to define a plurality of fixation points to the second vertebra. The attachment members are insertable through the holes of the plate and into the boney structure of a corresponding vertebra to fix the plate to the vertebra. | 04-11-2013 |
Donald Ray Koch, Easton, PA US
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20150096731 | Device and System for Dissipating Heat, and Method of Making Same - A device and system for dissipating heat includes a bent portion of pyrolytic graphite in which a-b planes at a center region of the bent portion follow a surface contour of the bent portion. A method for making a heat dissipating device includes bending a flat sheet of pyrolytic graphite such that a-b planes at a center region of a bent portion follow a surface contour of the bent portion. | 04-09-2015 |
Edward A. Koch, Mohnton, PA US
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20100266699 | Pharmaceutical Suspensions and Related Methods - A pharmaceutical suspension having a therapeutically effective amount of phenylephrine and a therapeutically effective amount of a first active agent consisting essentially of a first substantially water insoluble active agent having an average particle size of between about 10 and about 100 microns, an effective amount of non-reducing sweetener; an effective amount of water; and an effective amount of a suspending system; wherein the pharmaceutical suspension has a pH of from about 4 to about 6 and is substantially free of a reducing sugar and related methods. | 10-21-2010 |
Kristopher Koch, Lebanon, PA US
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20150089830 | PROCESS AND APPARATUS FOR TREATING CONTAINERS FOR STORING SUBSTANCES FOR MEDICAL, PHARMACEUTICAL OR COSMETIC APPLICATIONS - In a process and apparatus for treating or processing containers ( | 04-02-2015 |
Ronald N. Koch, Pittsburgh, PA US
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20100302061 | Meter Register and Remote Meter Reader Utilizing a Stepper Motor - A meter for flowing material, e.g., water, has a meter register having an electronic display, e.g., an LED or LCD display, and a mechanical read-out display driven by a stepper motor to record units of water that flowed through the meter. In the event of an electrical power failure, the LED or LCD readout values are lost, however, the mechanical read-out values remain. Further, signals are transmitted to a microprocessor of a meter register to change the rotation of the stepper motor so that the meter register can be used with different types of meters. Still further, a meter generator co-acting with a meter register forwards an electrical pulse signal after a quantity of material or utility passes through a water meter to a microprocessor of a remote reader. The remote reader includes an odometer coupled to a stepper motor. | 12-02-2010 |
20120179393 | Meter Register and Remote Meter Reader Utilizing a Stepper Motor - A meter for flowing material, e.g., water, has a meter register having an electronic display, e.g., an LED or LCD display, and a mechanical read-out display driven by a stepper motor to record units of water that flowed through the meter. In the event of an electrical power failure, the LED or LCD readout values are lost, however, the mechanical read-out values remain. Further, signals are transmitted to a microprocessor of a meter register to change the rotation of the stepper motor so that the meter register can be used with different types of meters. Still further, a meter generator co-acting with a meter register forwards an electrical pulse signal after a quantity of material or utility passes through a water meter to a microprocessor of a remote reader. The remote reader includes an odometer coupled to a stepper motor. | 07-12-2012 |
Stehen A. Koch, Collegeville, PA US
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20100192496 | PROCESS OF PRODUCING HIP, RIDGE OR RAKE SHINGLES, SHINGLES PRODUCED THEREBY AND STACKS OF THE SHINGLES - A process for making a plurality of hip, ridge or rake shingles, and the shingles produced thereby and stacks and packages of such shingles are provided. | 08-05-2010 |
Steven A. Koch, Collegeville, PA US
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20100146878 | PHOTOVOLTAIC ROOFING ELEMENTS, PHOTOVOLTAIC ROOFING SYSTEMS, METHODS AND KITS - The present invention relates generally to the photovoltaic generation of electrical energy. The present invention relates more particularly to photovoltaic roofing products for use in photovoltaically generating electrical energy. One aspect of the invention is a photovoltaic roofing element comprising: a flexible roofing substrate; a photovoltaic element disposed on the flexible roofing substrate; and an electrical connector operatively coupled to the photovoltaic element, wherein the flexible roofing substrate has formed therein a recess shaped to at least partially receive the electrical connector. | 06-17-2010 |
Walter J. Koch, Philadelphia, PA US
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20090053696 | Biomarker For Heart Failure - The present invention relates, in general, to heart failure, and, in particular, to a method of evaluating heart failure patients by monitoring β-adrenergic receptor kinase (βARK1) levels in lymphocytes from such patients. | 02-26-2009 |
20130274191 | METHODS AND COMPOSITIONS FOR THERAPEUTIC MODULATION OF ALDOSTERONE LEVELS IN HEART DISEASE - The disclosure describes the contribution of elevated levels of circulating alsosterone to heart disease and other hyperaldosteronic conditions. Since activation of beta-arrestin I (beta.arr-1) by the Angiotensin II (AngII) type 1 receptor (AT1R) mediates AngII-induced aldosterone production, beta-arrestin I (beta.arr-1) is a therapeutic target for heart disease. Specifically, the disclosure provides a beta.arr-1 protein fragment comprising the C-terminus of beta.arr-1 (beta.arr1ct; SEQ ID NO:3), compositions containing this protein fragment, and methods of using this protein fragment to reduce elevated levels of aldosterone in heart disease and other hyperaldosteronic conditions by inhibition of beta-arrestin (beta.arr-1). These compositions and methods are of therapeutic benefit in chronic heart failure and progression to heart failure after myocardial infarction (MI). Additionally, the invention provides an AngII peptide analog (SEQ ID NO:4), compositions containing this analog, and methods of using this analog for stimulation of beta.arr-1 activity and aldosterone production. | 10-17-2013 |
Walter J. Koch, Broomall, PA US
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20100048479 | ADRENAL GRK2 ACTIVITY AS A THERAPEUTIC TARGET FOR HEART FAILURE - The present invention relates to compositions and methods for the treatment of failing hearts. More specifically, the present invention provides for the inhibition of G-protein coupled receptor kinase 2 activity in the adrenal gland, which, for example, decreases catecholamine secretion and the sympathetic burden of the failing heart, thereby improving the cardiac adrenergic/inotropic reserve and overall contractile function. | 02-25-2010 |
20100190840 | TISSUE SPECIFIC GENE THERAPY TREATMENT - The invention provides nucleic acid segments, compositions and methods for the treatment of heart failure, vascular dysfunction, endothelial dysfunction, diabetes, [Ca | 07-29-2010 |