Patent application number | Description | Published |
20080306074 | Compositions Comprising Addl Receptors, Related Compositions, and Related Methods - Disclosed and claimed herein are compositions comprising ADDL receptors, related compositions, and related methods. ADDL receptors are typically, but perhaps not exclusively, localized at the post-synaptic density (PSD) of neuronal cells. Related compositions include, but are not limited to, compounds that affect, positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise. Related methods include, but are not limited to, procedures to screen for compounds that affect, either positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise. Other related methods include, but are not limited to, prevention and treatment of ADDL-related diseases, such as Alzheimer's disease, mild cognitive impairment, Down's syndrome, and the like, using compositions that inhibit, block, or otherwise interfere with ADDL binding to one or more receptors localized at the post-synaptic density of neuronal cells. | 12-11-2008 |
20090018084 | METHODS OF RESTORING COGNITIVE ABILITY USING NON-PEPTIDIC COMPOUNDS - Disclosed are methods of enhancing cognitive impairment in a patient wherein the cognitive impairment is due to ADDL neurotoxicity. The methods employ non-peptidic compounds having a molecular weight of less than 1000 and which can antagonize against formation of neurotoxic ADDLs from Aβ | 01-15-2009 |
20090018218 | METHODS OF MODIFYING AMYLOID beta OLIGOMERS USING NON-PEPTIDIC COMPOUNDS - Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β | 01-15-2009 |
20090285804 | Anti-ADDLs antibodies and uses thereof - The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. | 11-19-2009 |
20110098309 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS - Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers from amyloid β1-42 monomers using acylhydrazide compounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers using acylhydrazide compounds. | 04-28-2011 |
20110166061 | LONG LASTING FUSION PEPTIDE INHIBITORS FOR HIV INFECTION - The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections. | 07-07-2011 |
20130078269 | AMYLOID BETA PEPTIDES, ASSEMBLIES THEREOF, AND RELATED METHODS - The present invention provides amyloid β peptide assemblies composed of at least three amyloid β peptide subunits, wherein at least one of the amyloid β peptide subunits is an amyloid β peptide analog. The invention further relates to metal complexes of amyloid β peptide assemblies and the use of amyloid β peptide assemblies as vaccines and in the identification of agents that modulate assembly of the amyloid β peptide subunits. | 03-28-2013 |
20130150560 | AMYLOID BETA-DERIVED DIFFUSIBLE LIGANDS (ADDLs), ADDL-SURROGATES, ADDL-BINDING MOLECULES, AND USES THEREOF - The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders. | 06-13-2013 |
20130236466 | AMYLOID BETA-DERIVED DIFFUSIBLE LIGANDS (ADDLs), ADDL-SURROGATES, ADDL-BINDING MOLECULES, AND USES THEREOF - The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders. | 09-12-2013 |
20130330837 | MONOCLONAL ANTIBODIES THAT TARGET PATHOLOGICAL ASSEMBLIES OF AMYLOID BETA (ABETA) - Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods utilizing such antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution. | 12-12-2013 |
20140322731 | AMYLOID BETA-DERIVED DIFFUSIBLE LIGANDS (ADDLs), ADDL-BINDING MOLECULES, AND USES THEREOF - The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders. | 10-30-2014 |
Patent application number | Description | Published |
20080212307 | COMPUTER KEYBOARD BACKLIGHTING - Embodiments of a peripheral backlighting system for keyboards include one or more light-emitting panels exterior to the keyswitches of the keyboard. The panels are preferably electroluminescent material or light-emitting chemical cells and surround at least two sides, and preferably all sides, of the actuation portion of a keyswitch or the space in which the actuation portion slides up and down during use. Alternatively, the panel(s) may extend substantially continuously between and underneath a plurality of keyswitches, such as between a contact membrane and the bottom of the keyswitches, or underneath the contact membrane, or underneath a hooked plate that serves as a securement system for the keyswitches. The panels extend closely adjacent to the actuation portion or actuation path, or under the keyswitch, to be as far under the key cap as possible without extending into the keyswitch. Preferably, the keyswitch is translucent or partially translucent, and the housing plate or other plates over the light-radiant panels, if any, is at least partially translucent or transparent or has holes through which light may shine. This way, the light from the light-emitting panels radiates upward through, and preferably around the outer surface of, the translucent keycaps, rather than up through an aperture or lightpipe in the center of the keycaps. | 09-04-2008 |
20090091478 | COMPUTER KEYBOARD BACKLIGHTING - Embodiments of a peripheral backlighting system for keyboards include one or more light-emitting panels exterior to the keyswitches of the keyboard. The panels are preferably electroluminescent material or light-emitting chemical cells and surround at least two sides, and preferably all sides, of the actuation portion of a keyswitch or the space in which the actuation portion slides up and down during use. Alternatively, the panel(s) may extend substantially continuously between and underneath a plurality of keyswitches and/or deep within the keyboard, for example, between a contact membrane and the lowermost extremity of the keyswitches, or underneath the contact membrane, or underneath a hooked plate that serves as a securement system for the keyswitches. Preferably, the keyswitch is translucent or partially translucent, and the housing plate or other plates over the light-radiant panels, if any, is at least partially translucent or transparent or has holes through which light may shine. This way, the light from the light-emitting panels radiates upward through, and preferably around the outer surface of, the translucent keycaps, rather than up through an aperture or lightpipe in the center of the keycaps. | 04-09-2009 |
Patent application number | Description | Published |
20110096234 | METHOD AND SYSTEM FOR MULTIPLEXED TRANSPORT INTERFACE BETWEEN DEMODULATORS (DEMODS) AND SET-TOP BOX (STB) SYSTEM-ON-CHIPS (SOCS) - A multiplexed transport interface (MTSIF) may be utilized during communication between a demodulation module and a video processing system-on-chip (SoC). The MTSIF may enable concurrent demodulation of a plurality of input modulated video streams, via a plurality of demodulator chips within the demodulation module, by multiplexing data generated by the demodulator chips via the MTSIF during communication between the demodulator module and the video processing SoC. The MTSIF may also be utilized for communicating control signals, which may be used in controlling and/or managing operations of the demodulation module, the video processing SoC, and/or the MTSIF. Communication via the MTSIF may be synchronized. Packets communicated via the MTSIF may be timestamped. Timestamp counters may be used in the demodulation module and the video processing SoC to generate and/or track timestamps in communicated packets. The timestamp counter may be synchronized, using control signals communicated via the MTSIF. | 04-28-2011 |
20110110385 | Front-end system for processing composite wideband signals and method for utilizing same - According to one exemplary embodiment, a front-end system for processing a composite wideband signal comprises a pre-receiving unit including a multiplexer for separating the composite wideband signal into a plurality of filtered signals. The front-end system further comprises a plurality of discrete frequency band outputs corresponding to the plurality of filtered signals, and a tuner/down-converter coupled to at least one of the plurality of discrete frequency band outputs. In one embodiment, the pre-receiving unit of the front-end system further comprises a second multiplexer for separating at least one of the plurality of filtered signals into a second plurality of filtered signals. In one embodiment, the pre-receiving unit may further comprise a low noise amplifier for processing at least one of the plurality of filtered signals before it is input to the second multiplexer. | 05-12-2011 |
20120163290 | INTERNET PROTOCOL LOW NOISE BLOCK FRONT END ARCHITECTURE - Provided is a packet network adapter operable to receive a satellite intermediate frequency (IF) signal and determine whether the satellite IF signal includes DVB content based upon a network client request. When the satellite IF signal includes the requested DVB content, the satellite network adapter produces packetized data for delivery of the digital content to a network client or clients based upon the network client request. | 06-28-2012 |
20120224527 | CONDITIONAL ACCESS SYSTEM FOR SATELLITE OUTDOOR UNIT - A method and apparatus is disclosed to restrict the delivery of video, audio, and/or data to unauthorized end users in a satellite communications system. The satellite communications system includes one or more satellite receiving antennas, commonly referred to as a satellite dish, to receive downlink communications signals from one or more satellites. The transmission received by the one or more satellite receiving antennas is converted by an outdoor unit (ODU) for transmission to one or more indoor units (IDUs). The ODU receives control information from one or more satellites from the downlink communications signals, commonly referred to as in-band, and/or from out-of-band communications signals. The ODU may use the control information to restrict access to one or more communications channels embedded within the downlink communications signals to the unauthorized end users. | 09-06-2012 |
20120314812 | PHY sub-channel processing - Physical layer (PHY) sub-channel processing. A soft symbol decision stream is arranged into a number of sub-channels to reduce substantially the processing performed within a communication receiver on data that is not intended for that communication receiver. In other embodiments, a predetermined approach is employed to arrange the soft symbol decision stream into one or more frames; each frame may have one or more soft symbol blocks; and each soft symbol block may have one or more symbols. Each of the soft symbol blocks, within a frame, may be assigned to a sub-channel. Only the soft symbol blocks that contain information destined for the communication receiver need be decoded. Only the sub-channel that includes these soft symbol blocks, destined for this communication receiver, need be decoded. The soft symbol blocks not within the sub-channel may be discarded thereby recovering some of the processing capabilities of the communication receiver. | 12-13-2012 |
20130178182 | System for Processing Composite Wideband Signals - According to one exemplary embodiment, a front-end system for processing a composite wideband signal comprises a pre-receiving unit including a multiplexer for separating the composite wideband signal into a plurality of filtered signals. The front-end system further comprises a plurality of discrete frequency band outputs corresponding to the plurality of filtered signals, and a tuner/down-converter coupled to at least one of the plurality of discrete frequency band outputs. In one embodiment, the pre-receiving unit of the front-end system further comprises a second multiplexer for separating at least one of the plurality of filtered signals into a second plurality of filtered signals. In one embodiment, the pre-receiving unit may further comprise a low noise amplifier for processing at least one of the plurality of filtered signals before it is input to the second multiplexer. | 07-11-2013 |
20130297991 | FEC (forward error correction) decoder with dynamic parameters - FEC (Forward Error Correction) decoder with dynamic parameters. A novel means by which FEC parameters may be encoded into, and subsequently extracted from, a signal stream to allow for adaptive changing of any 1 or more operational parameters that govern communications across a communication channel. FEC parameters are encoded directly into a data frame such that the data frame is treated identical to all other data frames within the signal stream. When the data frame actually includes FEC parameters, it is characterized as a CP (Control Packet) type. For example, when decoding an MPEG stream, an MPEG block that includes FEC parameters, that MPEG block is characterized as a CP MPEG block. The means by which FEC parameters are encoded and extracted from the signal stream allows for much easier adaptive modification of the manner by which signal are encoded, modulated, and processed within a communication system. | 11-07-2013 |
20130312053 | METHOD AND SYSTEM FOR MULTIPLEXED TRANSPORT INTERFACE BETWEEN DEMODULATORS (DEMODS) AND SET-TOP BOX (STB) SYSTEM-ON-CHIPS (SOCS) - A multiplexed transport interface (MTSIF) may be utilized during communication between a demodulation module and a video processing system-on-chip (SoC). The MTSIF may enable concurrent demodulation of a plurality of input modulated video streams, via a plurality of demodulator chips within the demodulation module, by multiplexing data generated by the demodulator chips via the MTSIF during communication between the demodulator module and the video processing SoC. The MTSIF may also be utilized for communicating control signals, which may be used in controlling and/or managing operations of the demodulation module, the video processing SoC, and/or the MTSIF. Communication via the MTSIF may be synchronized. Packets communicated via the MTSIF may be timestamped. Timestamp counters may be used in the demodulation module and the video processing SoC to generate and/or track timestamps in communicated packets. The timestamp counter may be synchronized, using control signals communicated via the MTSIF. | 11-21-2013 |
20140173672 | Cross Layer Coordinated Channel Bonding - Different data communication architectures receive a wide variety of content, including audio and video content, for consumers. The architectures employ channel bonding to deliver more bandwidth than any single communication channel can carry. In some implementations, the communication architectures receive distributed video programming in the form of MPEG2 TS packets, flagged by marker packets. Channel bonding synchronization information may be present in packets defined above the data-link layer or received in fields within data-link layer frames. | 06-19-2014 |
20150143447 | Cross Layer Coordinated Channel Bonding - Different data communication architectures receive a wide variety of content, including audio and video content, for consumers. The architectures employ channel bonding to deliver more bandwidth than any single communication channel can carry. In some implementations, the communication architectures receive distributed video programming in the form of MPEG2 TS packets, flagged by marker packets. Channel bonding synchronization information may be present in packets defined above the data-link layer or received in fields within data-link layer frames. | 05-21-2015 |
20150195030 | Conditional Access System for Satellite Outdoor Unit - A method and apparatus is disclosed to restrict the delivery of video, audio, and/or data to unauthorized end users in a satellite communications system. The satellite communications system includes one or more satellite receiving antennas, commonly referred to as a satellite dish, to receive downlink communications signals from one or more satellites. The transmission received by the one or more satellite receiving antennas is converted by an outdoor unit (ODU) for transmission to one or more indoor units (IDUs). The ODU receives control information from one or more satellites from the downlink communications signals, commonly referred to as in-band, and/or from out-of-band communications signals. The ODU may use the control information to restrict access to one or more communications channels embedded within the downlink communications signals to the unauthorized end users. | 07-09-2015 |
20160080171 | Cross Layer Coordinated Channel Bonding - Different data communication architectures receive a wide variety of content, including audio and video content, for consumers. The architectures employ channel bonding to deliver more bandwidth than any single communication channel can carry. In some implementations, the communication architectures receive distributed video programming in the form of MPEG2 TS packets, flagged by marker packets. Channel bonding synchronization information may be present in packets defined above the data-link layer or received in fields within data-link layer frames. | 03-17-2016 |