Anantharamaiah
Gattadahalli M. Anantharamaiah, Birmingham, AL US
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20100143444 | PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES ASSOCIATED WITH EYE DISEASE - This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of eye disease and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The agents are highly stable and readily administered via an oral route or via intraocular injection. | 06-10-2010 |
20100286025 | SYNTHETIC APOLIPOPROTEIN E MIMICKING POLYPEPTIDES AND METHODS OF USE - The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical peptide, or a modified version thereof. Such peptides enhance low density lipoprotein (LDL) and very low density lipoprotein (VLDL) binding to and degradation by fibroblast or HepG2 cells. Also provided are possible applications of the synthetic peptides in lowering human plasma LDL/VLDL cholesterol levels, thus inhibiting atherosclerosis. The present invention also relates to synthetic peptides that can improve HDL function and/or exert anti-inflammatory properties. | 11-11-2010 |
20100298215 | SYNTHETIC APOLIPOPROTEIN E MIMICKING POLYPEPTIDES AND METHODS OF USE - The present invention provides methods for using synthetic apolipoprotein E (ApoE)-mimicking peptides. Also disclosed are provides methods for using synthetic apolipoprotein E (ApoE)-mimicking peptides to reduce plasma glucose levels. Methods of using the disclosed apolipoprotein E (ApoE)-mimicking peptides to treat diabetes and diabetic complications are also disclosed. | 11-25-2010 |
20110182992 | PEPTIDES AND PEPTIDE MIMETICS TO TREAT PATHOLOGIES ASSOCIATED WITH EYE DISEASE - This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of eye disease and/or other pathologies characterized by an inflammatory response, hi certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The agents are highly stable and readily administered via an oral route or via intraocular injection. | 07-28-2011 |
20120004720 | G-TYPE PEPTIDES AND OTHER AGENTS TO AMELIORATE ATHEROSCLEROSIS AND OTHER PATHOLOGIES - This invention provides novel peptides, and other agents, that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The peptides are highly stable and readily administered via an oral route. | 01-05-2012 |
20120035095 | ORALLY ADMINISTERED PEPTIDES SYNERGIZE STATIN ACTIVITY - This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention also provides a method of tracking a peptide in a mammal. In addition, the peptides inhibit osteoporosis. When administered with a statin, the peptides enhance the activity of the statin permitting the statin to be used at significantly lower dosages and/or cause the statins to be significantly more anti-inflammatory at any given dose. | 02-09-2012 |
20120245101 | SYNTHETIC APOLIPOPROTEIN E MIMICKING POLYPEPTIDES AND METHODS OF USE - The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical peptide, or a modified version thereof. Such peptides enhance low density lipoprotein (LDL) and very low density lipoprotein (VLDL) binding to and degradation by fibroblast or HepG2 cells. Also provided are possible applications of the synthetic peptides in lowering human plasma LDL/VLDL cholesterol levels, thus inhibiting atherosclerosis. The present invention also relates to synthetic peptides that can improve HDL function and/or exert anti-inflammatory properties. | 09-27-2012 |
Gattadahalli M. Anantharamaiah, Birmingham IN
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20130295042 | Peptides and Peptide Mimetics to Treat Pathologies Associated With Eye Disease - This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of eye disease and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The agents are highly stable and readily administered via an oral route or via intraocular injection. | 11-07-2013 |
G.m. Anantharamaiah, Birmingham, AL US
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20160002315 | APOLIPOPROTEIN MIMETICS AND USES THEREOF - The disclosure provides dosing regimens and methods for treating atherosclerosis with an effective amount of Apo E mimetic to provide sustained therapeutic effects even after withdrawal of the treatment. The dosing regimens and methods involve a treatment cycle followed by a rest phase wherein a subject is administered an effective amount of an Apo E mimetic during the treatment cycle and no Apo E mimetic during the rest phase. The treatment cycle and the rest phase can vary. | 01-07-2016 |
Nagendra Anantharamaiah, Raleigh, NC US
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20090258559 | STAPLE FIBER DURABLE NONWOVEN FABRICS - The invention provides durable nonwoven fabrics comprising staple fibers. Methods of preparing durable nonwoven fabrics based on staple fibers are also provided. The methods can include the steps of at least one of needle punching and hydroentangling. The durable nonwoven fabric can be subjected to additional bonding techniques, such as resin bonding and/or thermal bonding. The durable nonwoven fabrics of the invention provide improved durability over conventional nonwoven fabrics. Further advantages of the inventive nonwoven fabrics include maintaining the smooth surface qualities of the fabric and desirable feel of the fabric even with the enhanced durability. The inventive nonwoven fabrics can also be subjected to additional post-processing techniques that conventional nonwoven fabrics would otherwise be unable to withstand. Further, inks and/or dyes can more readily become adhered to the smooth nature of the surfaces of the inventive durable nonwoven fabrics. | 10-15-2009 |
Nagendra Anantharamaiah, Roanoke, VA US
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20140346107 | Filter Media Including Polymer Compositions and Blends - Polymer compositions that may be used to form fibers for a fiber web are generally described. In some embodiments, certain properties of the polymer compositions (e.g., molecular weight distribution, melt flow index, melt elasticity, and/or melt toughness) may allow the formation of fiber webs having fine fibers and a relatively low amount of process defects. In some instances, these properties of the polymer composition may be achieved by combining two or more polymer components. Fiber webs formed using the polymer composition may have increased performance and/or better structural characteristics compared to fibers webs formed using a single polymer component. | 11-27-2014 |
Prasanna Anantharamaiah, Bangalore IN
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20090282043 | System And Method For Concurrency Control Of Logically Grouped Shared Objects In A Multi-User Environment - A system and method for controlling access to an object, logically grouped shared objects or an object associated with one or more logical groups in a multi-user environment having different user privileges is disclosed. In one embodiment, a method for locking based on user and user privileges includes receiving a request from a user for access to one of an object or logically grouped shared objects or an object associated with one or more logical groups, determining whether the request from the user is for the object, if so, determining whether the object is locked by another user, if so, breaking the lock associated with the user holding the lock on the object and allowing access to acquire a write lock associated with the user and granting access to the object, and ending the request session. | 11-12-2009 |
Ramesh Anantharamaiah, Bangalore IN
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20110282944 | SYSTEMS AND METHODS FOR CONTENT SHARING ACROSS ENTERPRISE SOCIAL NETWORKS - Systems and methods for sharing content over a collection of social networks are disclosed. In one embodiment, a system comprises a first social network, a second social network, and at least one sharing table. The at least one sharing table is configured to share a first content from the first social network with the second social network. | 11-17-2011 |
Ramest Nittur Anantharamaiah, Bangalore IN
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20150271253 | HIGH PERFORMANCE ERP SYSTEM ENSURING DESIRED DELIVERY SEQUENCING OF OUTPUT MESSAGES - An embodiment of the present disclosure receives a respective set of input messages from a corresponding source system, with the messages of each set of input messages being received in a corresponding chronological (time) order. The input messages are processed using parallel processing approaches to generate corresponding output messages, with each output message being generated for delivery to a corresponding destination system. The destination system for each output message is identified only during such processing of the input messages. The output messages are queued and an output message to a destination system is transmitted only after output messages of all prior input messages from the same source system to the destination system are transmitted, while permitting output messages generated by processing of input messages from different source systems being permitted to be transmitted out-of-sequence. | 09-24-2015 |