Patent application number | Description | Published |
20080199485 | Method for enhancing T cell response - Embodiments of the invention disclosed herein relate to methods and compositions for exponentially increasing antigenic stimulation of class I MHC CD8 | 08-21-2008 |
20090169571 | SELECTED MA MOTIFS TO INCLUDE CELL DEATH AND/OR APOPTOSIS - The present application is directed to the use of dsRNA and/or ssRNA for the purpose of inducing apoptosis or cell death in proliferating cells. Specifically, low molecular weight and high molecular weight dsRNA and ssRNA are shown to induce apoptosis and/or cell death in proliferating cells, to arrest proliferation of transformed cells or tumor cells and to cause rapid induction of the cytokine TNF-alpha and/or also induce production of IL-12 which directs a Th-1 response. | 07-02-2009 |
20100303842 | PEPTIDE ANALOGUES - Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed. | 12-02-2010 |
20110274705 | METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS BY SIMULTANEOUS LOADING AND ACTIVATION OF SELECTED SUBSETS OF ANTIGEN PRESENTING CELLS - The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Tc1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-γ, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process. | 11-10-2011 |
20110301327 | EPITOPE ANALOGS - Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed. | 12-08-2011 |
Patent application number | Description | Published |
20090131355 | MULTICISTRONIC VECTORS AND METHODS FOR THEIR DESIGN - Embodiments of the present invention relate to multicistronic vectors and methods for their design. Methods and compositions of the invention include a vector including at least two cistrons, wherein a first cistron includes a first promoter and a first nucleic acid sequence encoding one or more therapeutic agents, and wherein a second cistron comprises a second promoter and a second nucleic acid sequence encoding one or more RNA molecules that interfere with the expression of a biological response modifier or the therapeutic agent, wherein the expression of the first sequence is under control of the first promoter and expression of the second sequence is under control of the second promoter. | 05-21-2009 |
20090148478 | COMBINATIONS OF TUMOR-ASSOCIATED ANTIGENS IN COMPOSITIONS FOR VARIOUS TYPES OF CANCERS - Disclosed herein are methods and compositions for inducing an immune response against various combinations of tumor-associated antigens, which can promote effective immunologic intervention in pathogenic processes. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs for the immunotherapy of patients with various types of cancer. Both immunogenic compositions for inducing an immune response to these combinations of antigens and methods for their use are disclosed. | 06-11-2009 |
20110230548 | MULTICISTRONIC VECTORS AND METHODS FOR THEIR DESIGN - Embodiments of the present invention relate to multicistronic vectors and methods for their design. Methods and compositions of the invention include a vector including at least two cistrons, wherein a first cistron includes a first promoter and a first nucleic acid sequence encoding one or more therapeutic agents, and wherein a second cistron comprises a second promoter and a second nucleic acid sequence encoding one or more RNA molecules that interfere with the expression of a biological response modifier or the therapeutic agent, wherein the expression of the first sequence is under control of the first promoter and expression of the second sequence is under control of the second promoter. | 09-22-2011 |
20110269949 | METHODS AND COMPOSITIONS TO ELICIT MULTIVALENT IMMUNE RESPONSES AGAINST DOMINANT AND SUBDOMINANT EPITOPES, EXPRESSED ON CANCER CELLS AND TUMOR STROMA - The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA | 11-03-2011 |
20110274723 | CANCER IMMUNOTHERAPY AND METHOD OF TREATMENT - The instant disclosure relates to methods for treating a cancer patient with an active immunotherapeutic, wherein the methods include assessing a patient's pre-existing immunoreactivity to at least one target antigen, choosing an immunotherapeutic regimen based on the level of pre-existing immunoreactivity, and administering an active immunotherapeutic according to the regimen. | 11-10-2011 |
20120148613 | MULTIVALENT ENTRAIN-AND-AMPLIFY IMMUNOTHERAPEUTICS FOR CARCINOMA - The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response. | 06-14-2012 |
Patent application number | Description | Published |
20090269443 | Process for Preparation of Packaged Heat-Preserved Aqueous Drink Comprising Casein Micelles and Tryptophan-Rich Peptides, and Products so obtained - A process to prepare packaged pasteurized or sterilized aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH. | 10-29-2009 |
20110165287 | PROCESS FOR THE PREPARATION OF PACKAGED HEAT-PRESERVED AQUEOUS DRINK COMPRISING CASEIN MICELLES AND TRYPTOPHAN-RICH PEPTIDES, AND PRODUCT SO OBTAINED - A process to prepare packaged pasteurised or sterilised aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH. | 07-07-2011 |
20130202770 | FOOD PRODUCT CONTAINING ETHYLCELLULOSE - The present invention has as an objective to provide an emulsion for shallow flying which has reduced spattering. This objective has been met by an emulsion which contains ethylcellulose particles. | 08-08-2013 |
20130260007 | OIL-IN-WATER EMULSION WITH IMPROVED SPATTERING BEHAVIOUR - Oil-in-water emulsion food product with improved spattering behaviour containing 0.01 to 3% w/w hydrophobin. | 10-03-2013 |
20130266714 | OILS AND FATS WITH IMPROVED SPATTERING BEHAVIOUR - Edible oil with improved spattering behaviour containing 0.01 to 1% w/w hydrophobin. | 10-10-2013 |
20150086701 | AERATED OIL CONTAINING SUCROSE FATTY ACID ESTER AND HYDROPHOBIN - The present invention relates to an oil containing gas bubbles, sucrose fatty acid ester and hydrophobin. Moreover the invention relates to a method of making these products, as well as using this composition to reduce spattering during shallow frying of food products. Aerated oil compositions are prepared which are stable during storage and remain homogeneous with respect to the hydrophobin. | 03-26-2015 |
20150327565 | METHOD FOR PRODUCTION OF AERATED WATER-IN-OIL EMULSIONS AND AERATED EMULSIONS - The present invention relates to a method for the production of aerated water-in-oil emulsions containing sucrose fatty acid esters. The invention further relates to aerated water-in-oil emulsions containing sucrose fatty acid esters, and to use of the composition for shallow flying and baking of food products. The method comprises a step wherein an oil is mixed with sucrose fatty acid ester, followed by aeration of this mixture. The obtained foamed oil is mixed with a water-in-oil emulsion. | 11-19-2015 |
Patent application number | Description | Published |
20110026702 | MANAGING COMMUNICATIONS - A method of handling a request to set up a call between a calling party and a called party in a communication network. A switching node that serves the called party receives a request to set up a call from the calling party, and the request includes information identifying the calling party. The switching node invokes a call handling service for a comparison between the information identifying the calling party with identities of calling parties in a remote database, the identities having been provisioned by a third party. This allows a third party to provision information in the database that can be used for all subscribers to the call handling service. On the basis of the comparison, a decision is made on whether to set up the call or whether to invoke alternative call handling procedures such as barring calling party identity with identities in the call or diverting the call to, for example, a voice mailbox. | 02-03-2011 |
20110105076 | METHOD AND SYSTEM FOR ADDING INFORMATION TO AN EMERGENCY CALL - A method and system, for adding emergency information to an emergency call, network transport of the emergency information and display to an emergency centre operator. Emergency information may comprise; position indication, ability to voice answer, indication of accompanying SMS, automated alarm etc. and is added as postfix to the emergency number by the phone as shown in FIG. | 05-05-2011 |
20110223881 | METHOD FOR SENDING EMERGENCY MESSAGES TO MOBILE TERMINALS - The invention relates to a method for sending an emergency message to mobile terminals located in an emergency area, in which at least location information and a subscriber identification code is stored in a database for a plurality of mobile terminals. Then the emergency area is determined. Next, a set of destination terminals is selected out of the database having location information that corresponds to the emergency area. To each of the destination terminals the emergency message is sent by means of an SMS message or a voice message using said subscriber identification code. By using the method according to the invention, all the terminals present in the emergency area can be reached, independent of whether they are subscribed to an SMS alerting service, and not depending on a certain channel to receive the message. | 09-15-2011 |
20110263220 | Regional Zone Based Mobile Charging - Network node and method in a telecommunication network, the network node receiving from a calling terminal a request to set up a call with a called terminal. The network node retrieves call set up information from a stored connection table and utilizes the retrieved data to set up the call. The connection table comprises data relating to set up of a call between the calling terminal and the called terminal. A first region class for the calling terminal is determined, and a second region class for the called terminal, each being associated with locations of the calling terminal and the called terminal, respectively. Furthermore, a rating category for the call to be set up is determined using the first region class and the second region class using the connection table. | 10-27-2011 |
20120178459 | Method of Routing a Call to One of a Plurality of User Equipment - Method of routing a call to one of a plurality of user equipment of a UMA/GAN-subscriber in a telecommunications network. The telecommunications network comprises a service control entity. Said service control entity determines whether said UMA/GAN-subscriber is within or outside a home area. The service control entity comprises a first indicator indicating at least one network address of a user equipment comprised by the plurality of user equipment to which the call is to be routed in case the UMA/GAN-subscriber is within the home area, and a second indicator indicating at least one network address of a user equipment comprised by the plurality of user equipment to which the call is to be routed in case the UMA/GAN-subscriber is outside the home area. | 07-12-2012 |