Goldberger, US
Ary Goldberger, Newton Center, MA US
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20100191130 | METHOD FOR DETECTING PATHOLOGIES USING CARDIAC ACTIVITY DATA - The invention relates to a method for determining a pathology in a subject, said method comprising: a) correlating N-N intervals with rate dependent fluctuations of electrocardiographic parameters derived from an electrocardiogram (ECG) of said subject or other recordings reflecting cardiac activity of said subject to derive electrocardiographic parameters correlation values, wherein said pathology is determined based on said correlation values. | 07-29-2010 |
Ary L. Goldberger, Boston, MA US
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20090316976 | Complexity-based analysis of cellular flickering - Provided herein are methods and systems for assessing cellular flickering. The methods include using a phase contrast microscope to obtain a plurality of images of a cell, digitizing and/or pixilating the plurality of images such that the plurality of images are segmented into an array of pixels, each pixel representing a portion of the cell, and measuring the fluctuations in the pixel intensities. The methods further include calculating a complexity measure for the individual pixels based on the measured fluctuations of the portions of the cell represented by the individual pixels. Such complexity measures can then be mapped and/or plotted in order to assess cellular flickering, and thereby assess biological function and other characteristics of the cell. | 12-24-2009 |
Ary L. Goldberger, Newton Center, MA US
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20100069762 | System And Method For Assessing Sleep Quality - An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same. | 03-18-2010 |
20140221780 | COMPLEXITY BASED METHODS AND SYSTEMS FOR DETECTING DEPRESSION - Major depression can affect multiple physiologic systems. Analysis of signals that reflect integrated function may be useful in probing dynamical changes in this syndrome. Complex variability can be used as a marker of healthy, adaptive control mechanisms and dynamical complexity decreases with aging and disease. The heart rate (HR) dynamics in non-medicated, young to middle-aged males during an acute major depressive episode exhibit lower complexity compared with healthy counterparts. By analyzing HR time series, a neuroautonomically regulated signal, during sleep, using the multiscale entropy method, a measure of complexity of HR dynamics can be determined. The complexity of the HR dynamics is significantly lower for depressed than for non-depressed subjects for the entire night and combined sleep stages 1 and 2, providing an indication of depression. These complexity signals, individually, or in combination with the complexity of other physiologic signals, can be used to define novel dynamical biomarkers of depression. | 08-07-2014 |
Ary L. Goldberger, Newton Centre, MA US
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20140330159 | QUANTITATIVE METHODS AND SYSTEMS FOR NEUROLOGICAL ASSESSMENT - Typical neurological examinations focus on qualitative and subjective assessments, including obtaining a patient history, assessing the patient's cognitive status, motor and sensory skills, and cranial nerve functionality. A quantitative assessment of neurological condition includes recording a subject performing a visuomotor task and processing the performance data to determine a level of complexity in the task activity and determine a complexity index. For a sample healthy population, a baseline level of complexity and baseline complexity index can be determined. A patient's complexity index can be compared to this baseline complexity index as an indication of disease or disability. A baseline complexity index can be determined for a patient at part of a health maintenance examination and used as the baseline complexity to detect disease or disability in the future based on lower complexity index values in future examinations. | 11-06-2014 |
Bruce A. Goldberger, Newberry, FL US
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20090197283 | DEVICES AND METHODS FOR THE COLLECTION AND DETECTION OF SUBSTANCES - The present invention is a single self-contained device for collecting, transferring, extracting, and testing for the presence of a target analyte in a sample obtained from a surface by swabbing, solid materials (pills, capsules, unknown powders), air samples and biological and non-biological fluids. The device includes a swab, a retention well including eluent fluid, and analysis technologies which can include but are not limited to lateral flow testing analysis. The major improvement is the invention of rinsing the swab with proprietary elution fluid prior to testing thereby not compromising the chemistry and allowing for a wide variety of applications under extremely hot or cold field conditions. Also, the device is in one self-contained unit instead of having a separate water dropper or spray. Moreover, the shape of the device is similar to a magic marker so it is more substantial than any drug tester on the market, as well in certain embodiments it can have grips resembling a gun and in certain embodiments can even emit sounds or smells when a surface is wiped or a positive test is attained | 08-06-2009 |
20100129922 | DEVICES AND METHODS FOR THE COLLECTION AND DETECTION OF SUBSTANCES - The present invention provides a single self-contained device for collecting, extracting, on-site testing, and transferring for forensic confirmatory analysis, a wide variety of substances including, but not limited to, drugs of abuse, explosives, weapons of mass destruction, food toxins and industrial wastes. Samples can be obtained from a surface by swabbing a suspect area or the testing of solid materials (pills, capsules, powders), air samples and biological and non-biological fluids by placing the substance in the device. The device includes a swab, a retention well including a wash, and analysis technologies that can be, for example, a lateral flow testing system. The swab is rinsed with a wash prior to testing thereby not compromising the chemistry of the detection technologies and allowing for a wide variety of applications under a number of field conditions. Also, the device is a single self-contained unit instead of having a separate reagent droppers or sprays, making it compact and easy to use. Moreover, the device is designed to not only collect and test samples but to seal the originally target analyte, not affected by testing procedures, in a specially designed cap for shipping under chain of custody documentation to a forensic laboratory for confirmatory testing. | 05-27-2010 |
Chen Goldberger, Skaneateles, NY US
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20150347396 | SYSTEMS AND METHODS FOR INTERNATIONALIZATION SUPPORT - Systems, methods, and tangible, non-transitory, computer readable media is described herein. For example, a system includes a portable non-destructive testing (NDT) device. The NDT device includes a display, a user interface, a memory storing an operations object having a first text in a first language, and a processor. The processor is configured to present the first text on the operations object via the display during an operation of the portable NDT device, and wherein the processor is configured to create a second text in a second language via the user interface of the NDT device, and to present the second text on the operations object as an alternative to the first text via the display during the operation of the NDT device. | 12-03-2015 |
Daniel Goldberger, Boulder, CO US
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20080200838 | WEARABLE, PROGRAMMABLE AUTOMATED BLOOD TESTING SYSTEM - The present invention is a programmable, automated device for measurement and analysis of blood analytes and blood parameters. The device components are preferably combined in a single housing and either programmed to initiate automatic, periodic blood sampling or initiate automatic blood sampling via operator input or in response to a predefined event or in response to a signal from another instrument. The device operates automatically to draw blood samples and analyze the drawn blood samples to obtain the desired blood readings. | 08-21-2008 |
20080275324 | Fluid Access Interface - The present invention relates generally to systems, apparatuses, and methods for obtaining a fluid sample from a patient. In particular, the present invention relates to a various types of fluid access interfaces for enabling contact between a patient blood sample and blood parameter sensors for the measurement of physiological parameters and blood constituents. | 11-06-2008 |
20090156922 | BLOOD MONITORING SYSTEM - The present invention is directed towards apparatuses and methods for the automated measurement of blood analytes and blood parameters for bedside monitoring of patient blood chemistry. Particularly, the current invention discloses a programmable system that can automatically draw blood samples at a suitable programmable time frequency (or at predetermined timing), can automatically analyze the drawn blood samples and immediately measure and display blood parameters such as glucose levels, hematocrit levels, hemoglobin blood oxygen saturation, blood gases, lactate or any other blood parameter. | 06-18-2009 |
20100020309 | BLOOD MONITORING SYSTEM - The present invention is directed towards apparatuses and methods for the automated measurement of blood analytes and blood parameters for bedside monitoring of patient blood chemistry. Particularly, the current invention discloses a programmable system that can automatically draw blood samples at a suitable programmable time frequency (or at predetermined timing), can automatically analyze the drawn blood samples and immediately measure and display blood parameters such as glucose levels, hematocrit levels, hemoglobin blood oxygen saturation, blood gases, lactate or any other blood parameter. | 01-28-2010 |
20120108936 | FLUID ACCESS INTERFACE - The present invention relates generally to systems, apparatuses, and methods for obtaining a fluid sample from a patient. In particular, the present invention relates to a various types of fluid access interfaces for enabling contact between a patient blood sample and blood parameter sensors for the measurement of physiological parameters and blood constituents. | 05-03-2012 |
Daniel S. Goldberger, Boulder, CO US
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20080212071 | METHOD OF DETERMINING ANALYTE CONCENTRATION IN A SAMPLE USING INFRARED TRANSMISSION DATA - A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance. | 09-04-2008 |
20110196266 | HANDPIECE FOR ULTRASONIC MEDICAL DEVICES - Described are embodiments including methods and devices for venting a handpiece of a medical device. These embodiments provide a vent for the handpiece. A porous membrane is positioned over an opening of the vent to allow gas, including steam, to enter and escape from the handpiece and prevent liquids from entering the handpiece. Other embodiments include methods and devices for holding an ultrasonic driver assembly within a handpiece and preventing the ultrasonic driver assembly from rotating within the handpiece. These embodiments include positioning the ultrasonic driver assembly such that the ultrasonic driver assembly is held in place at a node of the ultrasonic driver assembly and an anti-rotation mechanism is also located at the node. | 08-11-2011 |
Jeffrey Goldberger, Skokie, IL US
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20110190834 | DEVICES AND METHODS FOR SUPPRESSION OF SYMPATHOEXCITATION - The present invention relates to devices and methods for suppression of sympathoexcitation and/or sudden cardiac death. In particular the present invention provides devices and methods which prevent sympathoexcitation and/or sudden cardiac death through an elevated heart rate stimulus. | 08-04-2011 |
20110224962 | Electrophysiologic Testing Simulation For Medical Condition Determination - A system simulates stimulation of scar tissue identified as hyper-enhanced areas in a medical image with variable luminance thresholds and categorizes partially-viable myocardium as distinct from non-viable scar tissue. A cardiac function analysis system includes a repository of imaging data representing a 3D volume comprising a patient heart. A model processor provides a model of the patient heart using the imaging data said model being for use in allocating electrical properties to model parameters determining electrical conductivity associated with image data classified as, (a) scar tissue, (b) impaired tissue and (c) normal heart tissue. The electrical properties allocated to scar tissue are different to electrical properties allocated to normal tissue. A stimulation processor simulates electrical stimulation of the patient heart using the model to identify risk of heart impairment. | 09-15-2011 |
Josh Goldberger, Chicago, IL US
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20100143679 | NANOSCALE LAMELLAR PHOTOCONDUCTOR HYBRIDS AND METHODS OF MAKING SAME - An article of manufacture and methods of making same. In one embodiment, the article of manufacture has a plurality of zinc oxide layers substantially in parallel, wherein each zinc oxide layer has a thickness d | 06-10-2010 |
Joshua Goldberger, Chicago, IL US
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20110233512 | VERTICAL INTEGRATED SILICON NANOWIRE FIELD EFFECT TRANSISTORS AND METHODS OF FABRICATION - Vertical integrated field effect transistor circuits and methods are described which are fabricated from Silicon, Germanium, or a combination Silicon and Germanium based on nanowires grown in place on the substrate. By way of example, vertical integrated transistors are formed from one or more nanowires which have been insulated, had a gate deposited thereon, and to which a drain is coupled to the exposed tips of one or more of the nanowires. The nanowires are preferably grown over a surface or according to a desired pattern in response to dispersing metal nanoclusters over the desired portions of the substrate. In one preferred implementation, SiCl | 09-29-2011 |
Joshua Goldberger, Berkeley, CA US
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20110168968 | FLUIDIC NANOTUBES AND DEVICES - Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth. | 07-14-2011 |
Joshua E. Goldberger, Columbus, OH US
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20120294902 | PEPTIDE AMPHIPHILES AND METHODS TO ELECTROSTATICALLY CONTROL BIOACTIVITY OF THE IKVAV PEPTIDE EPITOPE - The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the peptide amphiphiles of the present invention have increased solubility and reduced nanofiber bundling. The molecules may be used in pharmaceutical applications, for example for in vivo administration to human patients, by increasing biological activity of the compositions toward neurite outgrowth and nerve regeneration. | 11-22-2012 |
20140363378 | SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS - Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles in the circulation into cylindrical nanofibers in the acidic extracellular environment of tumors which can be used to achieve a higher relative concentration of imaging, drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium. | 12-11-2014 |
Mattie L. Goldberger, Crystal, MN US
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20150119709 | MEDICAL FLUID INJECTION MANIFOLD - A powered medical fluid injector may have a disposable medical fluid injection manifold that controls fluid routing between the injector and a patient line and also controls fluid flow to a pressure sensor contained within the manifold. In one example, the medical fluid injection manifold includes a manifold housing having at least two inlets for different pressurized medical fluids and at least two corresponding outlets. The medical fluid injection manifold may also have a pressure sensor configured to measure a hemodynamic pressure of a patient. The pressure sensor may be positioned within the manifold housing and in selective fluid communication with the one of the outlet ports of the manifold housing. | 04-30-2015 |
Ofir Goldberger, Menlo Park, CA US
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20120288849 | METHOD AND SYSTEM FOR ROBUST AND SENSITIVE ANALYSIS OF BEAD-BASED ASSAYS - Computer-implemented methods and systems are provided for the analysis of multiplex fluorescent-dyed microsphere assays. The methods of the invention provide for determination of differences in analyte quantities between samples obtained from multiplex fluorescent-dyed microsphere assays by analysis of individual bead fluorescence and adjusting for variance; variance-stabilization of the data, and determining significance with hypothesis testing with tolerance determined by power estimation. The methods of the invention provide a benefit in allowing access to low signal or poor quality data, increased statistical power and decreased variability compared to standard curve methodology. | 11-15-2012 |
Valeriu Goldberger, Waltham, MA US
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20140192710 | ROUTER - A router includes a first communications port, a second communications port, and a processor that is configured to transmit data via at least one of the first communications port or the second communications port. | 07-10-2014 |