Patent application number | Description | Published |
20080241827 | Methods For Detecting A Mutant Nucleic Acid - The invention relates to methods for detection of genomic variation. The invention may be used to analyze nucleic acid sequences to detect low frequency mutations in a sample and/or screen for the presence of a disease. | 10-02-2008 |
20080254547 | SUPRACOLONIC AERODIGESTIVE NEOPLASM DETECTION - The invention provides methods and materials for detecting supracolonic aerodigestive premalignant and malignant neoplasms. Specifically, the invention provides methods and materials for determining whether a stool sample from a mammal contains a neoplasm-specific marker from a neoplasm located in the supracolonic aerodigestive tissue of a mammal. | 10-16-2008 |
20090047694 | Clinical Intervention Directed Diagnostic Methods - The invention provides methods for assessing the clinical status of a patient. In particular, the invention provides methods for identifying the presence of or likelihood of disease or disease recurrence. In practice, methods of the invention provide the ability to screen patients into one of three distinct clinical categories. Based upon measurement of clinically-relevant biomarkers in a sample obtained from a patient, the invention allows the unambiguous identification of patients who are not at risk for or do not have the relevant disease, the unambiguous identification of patients at increased risk or who have the disease; and the identification of patients who should receive standard of care treatment and/or monitoring. Use of the invention maximizes the number of patients who will receive accelerated intervention or monitoring and minimizes those patients who will receive unnecessary standard of care or accelerated intervention or monitoring. | 02-19-2009 |
20090075266 | MULTIPLE ANALYTE DIAGNOSTIC READOUT - The invention provides methods for assessing clinical status through the creation of a diagnostic readout based upon the analysis of multiple biomarkers. According to the invention, an algorithm is provided that allows the use of multiple biomarker thresholds from a patient sample to be used in order to increase the sensitivity and specificity of a diagnostic procedure. | 03-19-2009 |
20090170077 | Method for detecting recombinant event - Methods relating to isolating and amplifying chimeric nucleic acid molecules are provided. The methods of the invention are useful for detecting chromosome translocation events associated with diseases or conditions, such as cancer. | 07-02-2009 |
20090291436 | METHODS FOR DETECTING NUCLEIC ACIDS INDICATIVE OF CANCER - The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer. | 11-26-2009 |
20090325153 | ANALYSIS OF HETEROGENEOUS NUCLEIC ACID SAMPLES - Methods for capturing and characterizing low frequency nucleic acid molecules indicative of diseases such as cancer (e.g. adenomas or early stage cancers) are provided. In some aspects, a low complexity capture technique is combined with a high complexity analytical technique. In some aspects, samples may be analyzed using a digital analysis and/or a single molecule sequencing technique. | 12-31-2009 |
20100092981 | METHODS OF DETECTING HYPERMETHYLATION - Aspects of the invention relate to methods of detecting cancer, such as colon cancer. In aspects of the invention, methods for detecting the presence of hypermethylated genomic DNA in a biological sample are disclosed. Methods of the invention relate to detecting small amounts of hypermethylated nucleic acids in a biological sample. | 04-15-2010 |
20100151478 | METHODS FOR DISEASE DETECTION - The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample. | 06-17-2010 |
20100173320 | Methods for Detecting Nucleic Acids Indicative of Cancer - The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer. | 07-08-2010 |
20100248252 | METHODS FOR ANALYSIS OF MOLECULAR EVENTS - Methods and compositions are provided for detecting the presence of nucleic acid sequence variants in a subpopulation of nucleic acid molecules in a biological sample. These methods are particularly useful for identifying individuals with mutations indicative of cancer. | 09-30-2010 |
20100267041 | SERIAL ANALYSIS OF BIOMARKERS FOR DISEASE DIAGNOSIS - The present invention generally relates to serial analysis of biomarkers for disease diagnosis. In certain embodiments, the invention provides methods for diagnosing a disease including obtaining a sample from a subject, conducting a first assay to determine whether a first biomarker in the sample is positive or negative for a disease, and conducting a second assay to determine whether a second biomarker in the sample is positive or negative for the disease if the first assay produced a negative result. | 10-21-2010 |
20110014618 | DETECTION OF NUCLEIC ACIDS AND PROTEINS - The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay. | 01-20-2011 |
20110129837 | DETECTION OF NUCLEIC ACIDS AND PROTEINS - The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay. | 06-02-2011 |
20110177512 | METHOD FOR ASSURING AMPLIFICATION OF AN ABNORMAL NUCLEIC ACID IN A SAMPLE - The invention generally relates to methods for assuring amplification of an abnormal nucleic acid that is present as a percentage of total nucleic acid in a sample. In certain embodiments, methods of the invention involve providing a sample from a subject, in which the sample includes a total of nucleic acids, in which a percentage of the total are abnormal nucleic acids, extracting the total of nucleic acids from the sample, quantitatively analyzing the extracted nucleic acids, thereby determining an amount of amplifiable nucleic acids in the sample, and providing an amount of the nucleic acids for an amplification reaction that assures amplification of the abnormal nucleic acids in the sample, in which the provided amount is based on results from the quantitatively analyzing step. | 07-21-2011 |
20110177525 | ANTIBODIES AND METHODS OF DIAGNOSING DISEASES - The present invention generally relates to antibodies and use of these antibodies in diagnostic assays for various disease states, including cancer. In certain embodiments, the invention provides an isolated human or humanized antibody or functional fragment thereof including an antigen-binding region that is specific for an epitope on a protein, in which the epitope is specific to a tissue or body fluid and the epitope is indicative of a disease. | 07-21-2011 |
20110200621 | COMPOSITIONS AND METHODS FOR TREATING CANCER - This invention generally relates to compositions and methods for targeted delivery of chemotherapeutic agents to cancerous and pre-cancerous cells, thereby treating a cancer in a subject. | 08-18-2011 |
20120015369 | METHOD FOR DETECTING A RECOMBINANT EVENT - Methods relating to isolating and amplifying chimeric nucleic acid molecules are provided. The methods of the invention are useful for detecting chromosome translocation events associated with diseases or conditions, such as cancer. | 01-19-2012 |
20120064529 | DETECTION OF NUCLEIC ACIDS AND PROTEINS - The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay. | 03-15-2012 |
20120244536 | Detection of Bladder Cancer Recurrence - The present invention generally relates to methods of screening for cancer recurrence. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a parameter of the two or more nucleic acids and a parameter of the protein, and identifying the sample as positive for cancer recurrence if the parameters of at least one of the nucleic acids and the protein present in the sample are greater than their respective threshold parameters. In certain aspects of the invention, the nucleic acids include FGFR3, Vimentin, and NID2. In certain aspects of the invention, the protein includes MMP2 or MMP9. | 09-27-2012 |
20120252019 | Detection of Bladder Cancers - The present invention generally relates to methods of screening for cancer. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a parameter of the two or more nucleic acids and a parameter of the protein, and identifying the sample as positive for cancer if the parameters of at least one of the nucleic acids and the protein present in the sample are greater than their respective threshold parameters. In certain aspects of the invention, the nucleic acids include FGFR3, TWIST1, and NID2. In certain aspects of the invention, the protein includes MMP2 or MMP9. | 10-04-2012 |
20120252020 | Screening Assay for Bladder Cancer - The present invention generally relates to methods of screening for cancer. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a parameter of the two or more nucleic acids and a parameter of the protein, and identifying the sample as positive for cancer if the parameters of at least one of the nucleic acids and the protein present in the sample are greater than their respective threshold parameters. In certain aspects of the invention, the nucleic acids include FGFR3, p53, TWIST1, Vimentin, and NID2. In certain aspects of the invention, the protein includes MMP2 or MMP9. | 10-04-2012 |
20120309010 | DETECTION OF NUCLEIC ACIDS AND PROTEINS - The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay. | 12-06-2012 |
20130023427 | METHODS FOR ASSESSING GENOMIC INSTABILITIES IN TUMORS - The invention generally relates to methods for assessing genomic instabilities in a tumor sample. The invention may further be used to predict grade, stage, and prognosis of cancer in a patient. The invention further relates to cataloging the efficacy of therapeutics on specific genomic instabilities and generating a personalized therapeutic regimen for a cancer patient based upon their genomic instabilities. | 01-24-2013 |
20130023431 | Methods of Assessing Chromosomal Instabilities - Method of assessing or quantifying chromosomal instability in a subject, wherein the sample is obtained from an effluent, lavage, or organ wash. Methods of obtaining a whole genome sequence from an effluent, lavage, or organ wash. | 01-24-2013 |
20130109576 | METHODS FOR DETECTING MUTATIONS | 05-02-2013 |
20130122494 | DETECTION OF CANCER - Assays for detecting and grading disease by assessing amounts of GSTP1 nucleic acid and ADAM protein in a sample, and methods of using the assays. In some embodiments, the assays use single molecule sequencing to simultaneously assay both GSTP1 nucleic acid and ADAM protein. The methods are especially useful for detecting and grading cancers, for example, prostate cancer. | 05-16-2013 |
20130157875 | METHODS FOR ASSESSING GENOMIC INSTABILITIES - The invention generally relates to methods for assessing a fetal abnormality. | 06-20-2013 |
20130203058 | COMPOSITE ASSAY FOR DETECTING A CLINICAL CONDITION - The invention generally relates to methods for screening patients for one or more clinical conditions using a composite assay. According to certain aspects, methods of the invention involve isolating at least one nucleic acid from a biological sample obtained from the subject, detecting at least one sequence mutation and a chromosomal abnormality in the at least one nucleic acid in a single assay format, and identifying a clinical condition in said subject when both the sequence mutation and the chromosomal abnormality are present. | 08-08-2013 |
20130280727 | METHODS FOR DETECTING NUCLEIC ACIDS INDICATIVE OF CANCER - The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer. | 10-24-2013 |
20130309667 | PRIMERS FOR ANALYZING METHYLATED SEQUENCES AND METHODS OF USE THEREOF - Primers having abasic regions or mismatches for amplifying sequences suspected of having methylation. Primers having abasic regions or mismatches for amplifying sequences adjacent to suspected or known methylated sequences. Methods of using primers having abasic regions or mismatches for identification of methylated sequences or sequences adjacent to suspected or known methylation sequences. | 11-21-2013 |
20130310549 | PRIMERS FOR ANALYZING METHYLATED SEQUENCES AND METHODS OF USE THEREOF - Primers having abasic regions or mismatches for amplifying sequences suspected of having methylation. Primers having abasic regions or mismatches for amplifying sequences adjacent to suspected or known methylated sequences. Methods of using primers having abasic regions or mismatches for identification of methylated sequences or sequences adjacent to suspected or known methylation sequences. | 11-21-2013 |
20130310550 | PRIMERS FOR ANALYZING METHYLATED SEQUENCES AND METHODS OF USE THEREOF - Primers having abasic regions or mismatches for amplifying sequences suspected of having methylation. Primers having abasic regions or mismatches for amplifying sequences adjacent to suspected or known methylated sequences. Methods of using primers having abasic regions or mismatches for identification of methylated sequences or sequences adjacent to suspected or known methylation sequences. | 11-21-2013 |